a physiological state
ties in with a lot of Peter at Hyperlipid's thoughts on "physiological insulin resistance"
Plant-animal subsistence ratios and macronutrient energy estimations in worldwide hunter-gatherer diets
actually ties in with recent research like PURE and the Czech study into world dietary intakes
Heart disease is common in humans and chimpanzees, but is caused by different pathological processes
the money shot
"This difficulty in inducing advanced lesions in rodent and rabbit models is in stark contrast to the prevalence of severe atherosclerosis in humans, which occurs even in some individuals with mildly elevated LDL levels and no other obvious risk factors (Vasan et al. 2005). Indeed, despite statin treatment of their hypercholesterolemia 70% of such patients still have adverse cardiovascular events (Steinberg 2008).
The clinical manifestations of atherosclerosis also tend to be much commoner in humans than in nonhuman primates. While captive great apes have a relatively healthy diet from the perspective of atherosclerotic risk (low in cholesterol and saturated fat), this is not reflected in their serum lipid profiles."
There. the Chimpanzee Paradox, to add to the French, Israeli, Bulgarian and all the other paradoxes. Or as anyone with half a functional brain might think, the diet heart hypothesis/cholesterol hypothesis has failed yet again.