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    Avocatin B Protects Against Lipotoxicity and Improves Insulin Sensitivity in Diet‐Induced Obesity

    yoly
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    Avocatin B Protects Against Lipotoxicity and Improves Insulin Sensitivity in Diet‐Induced Obesity Empty Avocatin B Protects Against Lipotoxicity and Improves Insulin Sensitivity in Diet‐Induced Obesity

    Post by yoly on Tue Nov 12 2019, 09:28

    (A fat in avocados, eat more avocado. They already are making it a supplement in Canada.)

    Avocatin B Protects Against Lipotoxicity and Improves Insulin Sensitivity in Diet‐Induced Obesity

    https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201900688


    Abstract
    Scope

    The effects of an avocado‐derived fatty acid oxidation (FAO) inhibitor, avocatin B (AvoB), on glucose and lipid metabolism in models of diet‐induced obesity (DIO) and in vitro models of lipotoxicity are evaluated. The safety of its oral consumption in humans is also determined.

    Methods and results

    Mice are given high‐fat diets (HFD) for 8 weeks. Thereafter, AvoB or vehicle is administered orally twice weekly for 5 weeks. AvoB inhibits FAO which led to improved glucose tolerance, glucose utilization, and insulin sensitivity. AvoB's effects on metabolism under lipotoxic conditions are evaluated in vitro in pancreatic β‐islet cells and C2C12 myotubes. AvoB inhibits FAO and increases glucose oxidation, resulting in lowering of mitochondrial reactive oxygen species that improves insulin responsiveness in C2C12 myotubes and insulin secretion in INS‐1 (832/13) cells, respectively. A randomized, double‐blind, placebo‐controlled clinical trial in healthy human participants is conducted to assess the safety of AvoB consumption (50 mg or 200 mg per day for 60 days). AvoB is well‐tolerated and not associated with any dose‐limiting toxicity.

    Conclusion

    Therapeutic agents that are safe and effectively inhibit FAO and improve DIO‐associated pathologies are currently not available. AvoB's mechanism of action and favorable safety profile highlight its nutritional and clinical importance.

    Jan1
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    Avocatin B Protects Against Lipotoxicity and Improves Insulin Sensitivity in Diet‐Induced Obesity Empty Re: Avocatin B Protects Against Lipotoxicity and Improves Insulin Sensitivity in Diet‐Induced Obesity

    Post by Jan1 on Thu Nov 14 2019, 20:10

    Many thanks for posting this Yoly …

    Perhaps it's time to eat some avocado!

    https://lowcarbdiabetic.forumotion.co.uk/t1495-twenty-interesting-reasons-to-love-avocados?highlight=Avocados

    Interesting to read that they are making it a supplement in Canada.

    All the best Jan

      Current date/time is Wed Dec 11 2019, 22:47