Home
Hibiscus sabdariffa L. Extract Alleviates Vascular Endothelial Dysfunction by Enhancing Nitric Oxide Bioavailability in High-Fructose Diet Induced Insulin Resistance Rats
Published Jun 22, 2018
https://www.tci-thaijo.org/index.php/SRIMEDJ/article/view/130005
Abstract
Background and Objectives: This study evaluated the effect of Hibiscus sabdariffa extract (HSE) on vascular endothelial function and mechanism involved in insulin resistance rats induced by high-fructose diet (HFD).
Methods: Male Sprague-Dawley rats were fed with HFD for 18 weeks to induce insulin resistance. Oral administration of HSE (200 or 500 mg/kg/day) was performed in the last four weeks. Vascular function and metabolic parameters were evaluated.
Results: HSE (200 and 500 mg/kg) improved glucose tolerance, reduced blood pressure, and restored vascular endothelial dysfunction in rats fed with HFD (p<0.05). Moreover, HSE 500 mg/kg enhanced nitric oxide bioavailability by restoring plasma NOx level and eNOS expression, and reducing O2•− production in insulin resistance rats (p<0.05).
Conclusion: Our results suggest that HSE alleviated vascular endothelial dysfunction in HFD fed rats that was associated with increasing in NO bioavailability.
Published Jun 22, 2018
https://www.tci-thaijo.org/index.php/SRIMEDJ/article/view/130005
Abstract
Background and Objectives: This study evaluated the effect of Hibiscus sabdariffa extract (HSE) on vascular endothelial function and mechanism involved in insulin resistance rats induced by high-fructose diet (HFD).
Methods: Male Sprague-Dawley rats were fed with HFD for 18 weeks to induce insulin resistance. Oral administration of HSE (200 or 500 mg/kg/day) was performed in the last four weeks. Vascular function and metabolic parameters were evaluated.
Results: HSE (200 and 500 mg/kg) improved glucose tolerance, reduced blood pressure, and restored vascular endothelial dysfunction in rats fed with HFD (p<0.05). Moreover, HSE 500 mg/kg enhanced nitric oxide bioavailability by restoring plasma NOx level and eNOS expression, and reducing O2•− production in insulin resistance rats (p<0.05).
Conclusion: Our results suggest that HSE alleviated vascular endothelial dysfunction in HFD fed rats that was associated with increasing in NO bioavailability.
