More Science, Can You Believe It?

I'll read that later after I've eaten some cheese.

Spotted this on twitter unfortunately the full text is not available yet 

 High low-density lipoprotein cholesterol inversely relates to dementia in community-dwelling older adults

Abstract

Background: The relationship between cholesterol and cognitive function is unclear from the previous studies. This study was conducted to explore this association in older Chinese adults.

Methods: Data were from the Shanghai Aging Study, comprising 3836 residents aged 50 years or over in an urban community. Diagnoses of dementia and mild cognitive impairment were established according to the fourth edition of diagnostic and statistical manual of mental disorders (DSM-IV) and Petersen criteria. Multivariate logistic regression models, non-matched and propensity score (PS) matched, were used to examine the association between cholesterol levels and cognitive function.

Results: There was a significantly higher proportion of participants with low levels of total cholesterol (TC) and low density lipoprotein cholesterol(LDL-C) in the dementia group than in groups without dementia (P<0.05). High LDL-C level was inversely associated with dementia, with a negative trend in the PS matched model. TC and high density lipoprotein cholesterol (HDL-C) were not significantly related to dementia in either non-matched models or PS matched models.

Conclusion: Our result indicates that high level of LDL-C is inversely associated with dementia. High level of LDL-C may be considered as a potential protective factor against cognition decline.

https://www.frontiersin.org/articles/10.3389/fneur.2018.00952/abstract

Could statins be playing a part in increasing the risks of dementia as well

I found the full paper here

http://sci-hub.tw/10.3389/fneur.2018.00952

need to read it later.

I've actually seen statins recommended for Alzheimers. Probably washed down with Coca-Cola.

Meanwhile, have a cow

OF COWS AND MEN: REVIEWING THE LINK BETWEEN
MILK FAT AND HUMAN HEALTH

https://ecommons.cornell.edu/bitstream/handle/1813/59846/Rico%20(manu).pdf?sequence=2

Saturated Fat: Part of a Healthy Diet
Victoria M. Gershuni1

http://sci-hub.tw/https://doi.org/10.1007/s13668-018-0238-x

https://www.dlife.in/news-and-research-articles-on-diabetes-obesity-lipids/doctoring-facts-the-ugly-face-of-medical-research/

interesting how some of the best doctors like Michael Eades and of course Richard Bernstein were engineers

http://fullmeasure.news/news/cover-story/the-statins-war

https://mailchi.mp/ddf447abb1da/reversing-type-2-diabetes-report-1472601

From what I recall David Unwin alone is now saving over £50 000/year - and no use of expensive slop

https://twitter.com/DrScottMurray/status/1046505750686826498

it seems what he listed isn't the actual slop used, just a similar one.

Did I do this one yet?

Haemoglobin A1c even within non-diabetic level
is a predictor of cardiovascular disease in a general
Japanese population: the Hisayama Study

https://cardiab.biomedcentral.com/track/pdf/10.1186/1475-2840-12-164

follows on from some of the classic studies like EPIC-Norfolk

Study on the levels of glycosylated lipoprotein in patients with
coronary artery atherosclerosis

https://sci-hub.tw/10.1002/jcla.22650

I haven't yet psyched myself up to watch the interview of Dave Feldman and Peter Attia, in fact I probably won't, life's too short. Attia and Dayspring are all about lowering LDL, this is yet another study that shows the problem is DAMAGED LDL. It'll never catch on though, we don't have a drug for that.

Glucagon is the key factor in the development of diabetes

https://link.springer.com/content/pdf/10.1007%2Fs00125-016-3965-9.pdf

another from Roger Unger et al.

Identifying hyperinsulinaemia in the absence of impaired glucose tolerance:
An examination of the Kraft database

https://www.researchgate.net/publication/304535127_Identifying_hyperinsulinaemia_in_the_absence_of_impaired_glucose_tolerance_An_examination_of_the_Kraft_database

a tribute to Joseph Kraft
and an original

https://pharmacistcatherinedotnet.files.wordpress.com/2017/02/kraft-1975.pdf

Just published today

Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial

Conclusions Consistent with the carbohydrate-insulin model, lowering dietary carbohydrate increased energy expenditure during weight loss maintenance. This metabolic effect may improve the success of obesity treatment, especially among those with high insulin secretion.

https://www.bmj.com/content/363/bmj.k4583

High Low-Density Lipoprotein Cholesterol Inversely Relates to Dementia in Community-Dwelling Older Adults: The Shanghai Aging Study

Conclusion: Our result indicates that high level of LDL-C is inversely associated with dementia. High level of LDL-C may be considered as a potential protective factor against cognition decline.

https://www.frontiersin.org/articles/10.3389/fneur.2018.00952/full?utm_source=F-NTF&utm_medium=EMLX&utm_campaign=PRD_FEOPS_20170000_ARTICLE

Didn't you just post the second one? Are you getting demented? hahahahaha oh I see the full version has now been published

The first one looks good, Cara Ebbeling and David Ludwig. Wait for the replies from the usual low carb antis.

James Di Nicolantonio has been busy too

Good Fats versus Bad Fats:
A Comparison of Fatty Acids in the Promotion
of Insulin Resistance, Inflammation, and Obesity

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140086/pdf/ms114_p0303.pdf

chris c wrote:
Didn't you just post the second one? Are you getting demented? hahahahaha

Did I   

Meanwhile 

The Failure to Measure Dietary Intake Engendered a Fictional Discourse on Diet-Disease Relations

Summary and Conclusions
Since its first clinical trial in the eighteenth century, the field of nutrition relied on the observable effects of an individual's dietary intake on his or her health. This scientific process led to the elimination of diet-related deficiencies and substantial improvements in public health. Nonetheless, beginning in the 1950s, the field allowed rigorous research to be obscured by the sensational but implausible results and conclusions generated by the pseudo-quantified anecdotal data generated via M-BMs. The devolution from rigorous scientific observation to anecdotal (i.e., self-reported) evidence led to a fictional discourse on diet-disease relations that resulted in both public and policy confusion, and a major loss of credibility for the nutrition sciences. We challenge the field to acknowledge the inherent flaws and empirical and theoretical refutations of M-BMs, and ensure that in the future, rigorous scientific methods (e.g., RCTs) are used to study the role of diet in chronic disease.

https://www.frontiersin.org/articles/10.3389/fnut.2018.00105/full

Looks like they have been reading John Ioannidis. Which is good.

Don't worry about the other one, when you first posted it only the abstract was available, I had to find the actual study on Sci-Hub and now they've posted it complete.

Prediabetes and
Cardiovascular Disease
Pathophysiology and Interventions for
Prevention and Risk Reduction

http://sci-hub.tw/10.1016/j.ecl.2017.10.001

pretty good stuff and adds to the concept that by the time you are actually diagnosed with diabetes the damage has been occurring for years

MECHANISMS OF INSULIN ACTION AND INSULIN
RESISTANCE
Max C. Petersen and Gerald I. Shulman

http://sci-hub.tw/10.1152/physrev.00063.2017

91 pages! I'm only halfway through so far

chris c wrote:91 pages! I'm only halfway through so far

I'll leave that one for you Chris maybe you could give us a short summary when you have got through it 

I might not be able to remember what with the Alzheimers.

Actually my problem is the exact opposite, my brain is totally full of stuff I no longer need to remember but can't forget, like names of people who died, companies that went out of business and part numbers of obsolete things. I have to plough through all of that to find what I wanted to remember from yesterday. Often I can't remember people's names when I'm talking to them, then I remember just as I'm talking to the next person whose name I can't remember.

All I can say so far is that it's complicated. Very very complicated. I might have to read it several times. See you in a few months.

Still ploughing through the insulin resistance monograph, very interesting but slow going.

Meanwhile

High-Dose, Diazoxide-Mediated Insulin Suppression
Boosts Weight Loss Induced by Lifestyle Intervention

http://sci-hub.tw/10.1210/jc.2018-01147

Diazoxide is pretty potent stuff, Do Not Try This At Home! It's more of a proof of concept study, lowering insulin increases weight loss. Who knew? Of course there's an easier way to lower insulin, it's on the tip of my tongue . . .

"As we have shown previously, as well as in
the current study, the actual fasting insulin levels are
critical determinants of the degree of fat loss. It was
observed that clinically meaningful weight loss (.10 kg)
only occurred if fasting insulin levels were below a
specified limit, i.e., 4.5 mU/L in the van Boekel et al. study
(16) and 5.5 mU /L in the current study."

Which ties in nicely with the Ebbeling/Ludwig study above and pokes a finger in the eye of the Insulin Deniers, who have been out in force

https://twitter.com/davidludwigmd/status/1063623505797922816

https://twitter.com/juliaoftoronto/status/1063454296392572929

Julia Belluz is supposedly Yoni Friedhoff's main squeeze, looks like she is now in e three-way with Kevin Hall

https://www.vox.com/science-and-health/2018/11/16/18096633/keto-low-carb-diet

Just needs Stephan Guyenet to join in with his insulin makes you thin nonsense and she'll be airtight. Did I really write that?

A longitudinal 20 years of follow up showed a decrease
in the survival of heart failure patients who
maintained low LDL cholesterol levels

https://sci-hub.se/10.1093/qjmed/hcy043

oops!

I haven't read this yet

Dietary fat: From foe to friend?

including Walt Wallet along with Ludwig and Jeff Volek

http://science.sciencemag.org/content/362/6416/764

chris c wrote:I haven't read this yet

Dietary fat: From foe to friend?

including Walt Wallet along with Ludwig and Jeff Volek

Who would have thunk it strange bedfellows indeed 

I'm not sure if Willett has actually retired or not. Maybe he tried his Gorilla Diet of 83 portions of fruit and veg a day and decided he was deluded after all.

Earlier he wrote this

https://varputavi.wordpress.com/2010/12/21/fat-is-not-the-problem-says-dr-walter-willett/

The Disputed Science on Saturated Fats

https://www.nutritioncoalition.us/saturated-fats-do-they-cause-heart-disease/

How an outsider in Alzheimer’s research bucked the prevailing theory — and clawed for validation

https://www.statnews.com/2018/10/29/alzheimers-research-outsider-bucked-prevailing-theory/

fascinating stuff and demonstrates how hard it can be to either get research grants or publication when you step out of line.

A few more, I'm not sure if the Sci-Hub links still work, it looks like it has been under attack again

What are interesterified fats and should we
be worried about them in our diet?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497165/pdf/NBU-42-153.pdf

amazing, they replace trans fats with these and have no clue what they do

Great to see Franziska Spritzler on a comparatively mainstream site

https://www.healthline.com/nutrition/low-carb-diet-for-diabetes

Banting Lecture 1988
Role of Insulin Resistance
in Human Disease
GERALD M. REAVEN

http://sci-hub.tw/10.2337/diab.37.12.1595

Lamarche, B. (1998). Fasting Insulin and Apolipoprotein B Levels and Low-Density Lipoprotein Particle Size as Risk Factors for Ischemic Heart Disease.

http://sci-hub.tw/10.1001/jama.279.24.1955

Twenty years later and The Anointed are still banging on as if LDL was the only relevant factor

chris c wrote:
Twenty years later and The Anointed are still banging on as if LDL was the only relevant factor

But it's good for Big Pharma need to keep the statin sales up

https://oilmarketforecast.com/2018/12/statins-market-segmentation-by-2018-2023-industry-demands-types-size-shares-revenue-with-experts-analysis/

Astrovastatin

hahahaha they came from outer space!

Yes now they are mostly off patent they have to find ways of selling more to make their profits. While of course not interfering with the market for PCSK9 inhibitors.

Maybe they'll bring back Dr Reckless - yes that really was his name - who wanted to put them in the drinking water.

I've read some extremely obscure papers on the details involved in balancing insulin and glucagon, etc. Here's one of more relevance

The Hypoglycemic Action of Ketones. II. Evidence for a
Stimulatory Feedback of Ketones on the Pancreatic
Beta Cells *

Roger Unger et al. from way back in 1964

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC441933/pdf/jcinvest00459-0078.pdf

OK they were using exogenous ketones rather than a keto diet, and in dogs, but

"This combination of a ketone-induced reduction
in blood glucose concentration during the hyperketonemia
of starvation, coupled with a ketonemediated
inhibition of glucose utilization by
peripheral tissues, may not only play a role along
with the changes in NEFA (41), growth hormone
(34, 38), and glucagon (5) in shifting the
fuel used for energy purposes from carbohydrate
to fat, but also may result in the slower dissipation
of protein precursors of glucose and thereby
conserve glucose for use by the brain, a tissue for
which glucose is an obligatory substrate (42).
Such changes in metabolism would be a distinct
advantage for survival of the organism, since
calories stored as fat could be used for over-all
energy without the supervention of fatal ketoacidosis
and at the same time permit glucose,
produced by the liver from protein precursors and
glycerol, to be portioned out gradually under circumstances
where its utilization by the brain
rather than the peripheral tissues is likely to
occur."

Over fifty years later and a lot of people still don't know this.

Lipid levels in patients hospitalized with coronary
artery disease: An analysis of 136,905 hospitalizations
in Get With The Guidelines

http://sci-hub.tw/10.1016/j.ahj.2008.08.010

thanks to Angela Stanton

"In a large cohort of patients hospitalized with CAD,
almost half have admission LDL <100 mg/dL, whereas less
than a quarter have LDL N130 mg/dL. The LDL levels
<70 mg/dL are observed in only 17.6% of patients.
Admission HDL levels are <40 mg/dL in 54.6% of patients
hospitalized with CAD, whereas <10% of patients have
admission HDL levels ≥60 mg/dL"

so obviously the LDL still has not been lowered enough <sigh>

The antidote thanks to Tom Naughton

Serum Cholesterol and Atherosclerosis in Man

https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.23.6.847

"No correlation could be observed between
the serum cholesterol level and the amount
and severity of atheroselerosis in the arteries."

in 1961

Ketogenic Diet Myths vs. Facts

https://ninateicholz.com/ketogenic-diet-myths-vs-facts/

Kevin Stock

https://www.kevinstock.io/health/health-dangers-of-a-plant-based-diet/

https://www.kevinstock.io/health/health-dangers-of-plant-based-foods/