by Eddie Thu Sep 18 2014, 11:02
Type two diabetics on insulin and other drugs.
Those on Metformin therapy had the lowest death rates, so that group was used as the reference.
In terms of primary outcome—that is, consideration of first adverse events only:
Sulfonylurea therapy resulted in patients being 1.4 times more likely to suffer one of these outcomes.
A combination of Metformin and Insulin resulted in 1.3 times greater risk.
Insulin therapy alone resulted in 1.8 times greater risk.
Those considered to be at greater risk because of glycosylated hemoglobin had as much as 2.2 times greater risk with Insulin therapy alone. When considering any of these events happening, whether they were the first event or a subsequent one, the results were even more dramatic:
Insulin monotherapy resulted in:
2.0 times more myocardial infarctions.
1.7 time more major adverse cardiac events
1.4 time more strokes
3.5 times more renal complications
2.1 time more neuropathy
1.2 times more eye complications
1.4 times more cancer
2.2 times more deaths
This information extracted from this study.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612791/Eddie