Imbalanced insulin action in chronic over nutrition: Clinical harm,
molecular mechanisms, and a way forward
https://www.sciencedirect.com/science/article/pii/S002191501630048X?via%3Dihub#fig1
pdf is available - but it is 58 pages.
Took me a while to get through it and there's so much there that I really need to read it several more times. It should be Required Reading for all dieticians, especially the ones who believe "insulin can't make you fat because it has no calories" and anyone who mentions the Insulin Fairy.
"We also review the origins of widespread, chronic overnutrition. Despite its apparent complexity, one
factor stands out. A sophisticated junk food industry, aided by subsidies from willing governments, has
devoted years of careful effort to promote overeating through the creation of a new class of food and
drink that is low- or no-cost to the consumer, convenient, savory, calorically dense, yet weakly satiating.
It is past time for the rest of us to overcome these foes of good health and solve this man-made epidemic"
They look specifically at the effect of insulin resistance on different pathways where some are upregulated while others are downregulated. I could spend more than the rest of my life chasing down the references.
molecular mechanisms, and a way forward
https://www.sciencedirect.com/science/article/pii/S002191501630048X?via%3Dihub#fig1
pdf is available - but it is 58 pages.
Took me a while to get through it and there's so much there that I really need to read it several more times. It should be Required Reading for all dieticians, especially the ones who believe "insulin can't make you fat because it has no calories" and anyone who mentions the Insulin Fairy.
"We also review the origins of widespread, chronic overnutrition. Despite its apparent complexity, one
factor stands out. A sophisticated junk food industry, aided by subsidies from willing governments, has
devoted years of careful effort to promote overeating through the creation of a new class of food and
drink that is low- or no-cost to the consumer, convenient, savory, calorically dense, yet weakly satiating.
It is past time for the rest of us to overcome these foes of good health and solve this man-made epidemic"
They look specifically at the effect of insulin resistance on different pathways where some are upregulated while others are downregulated. I could spend more than the rest of my life chasing down the references.