THE LOW CARB DIABETIC

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THE LOW CARB DIABETIC

Promoting a low carb high fat lifestyle for the safe control of diabetes. Eat whole fresh food, more drugs are not the answer.


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    Diabetes drug trial needs to widen participants to understand full impact of drugs

    graham64
    graham64
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    Diabetes drug trial needs to widen participants to understand full impact of drugs Empty Diabetes drug trial needs to widen participants to understand full impact of drugs

    Post by graham64 Mon Jul 17 2017, 21:55

    More work needs to be done to examine the real world effects of the commonly prescribed diabetes drug empagliflozin, new research in the journal Diabetes Therapy finds.

    Examining data from over 60,000 patients with type 2 diabetes, researchers from the University of Surrey discovered that the highly-publicised cardiovascular benefits of the popular diabetes drug empagliflozin cannot be applied to the vast majority of patients with the illness.

    An international safety trial of empagliflozin, and other drugs in the sodium-glucose co-transporter 2 (SGLT2) inhibitor drug class, made the surprising discovery that these medications positively impact upon the workings of cardiovascular systems, including a decreased risk of heart attacks. Despite being hailed as ground-breaking, limitations of the trial were identified due to its focus on patients identified as high risk of cardiovascular disease.

    Equipped with this knowledge, researchers from the University of Surrey examined the potential impact of this drug on those deemed at lower risk of cardiovascular disease. Researchers found that only 11 per cent of patients with type 2 diabetes who were prescribed empagliflozin were identified as being at as high a risk of cardiovascular disease as those in the trial. They concluded that these patients may not see any cardiovascular improvements from the drug. Similarly, only 16 per cent of patients with type 2 diabetes who were not prescribed the drug were identified as being as high a risk of cardiovascular disease as those in the trial.

    Such findings highlight the limitations of clinical trials which are often only directly applicable to a small proportion of people whom the medications are prescribed for and often leads to misconceptions about the workings of the drug.

    Lead author of the paper, Dr Andy McGovern, from the University of Surrey said: "The benefits of this drug for patients at high risk of cardiovascular disease are clear. However what we have found a major limitation of the clinical trial; it can only be applied to a small proportion of people with type 2 diabetes.

    "Recognising this shortcoming will help clinicians better explain to patients how this drug will benefit them."

    https://medicalxpress.com/news/2017-06-diabetes-drug-trial-widen-full.html
    chris c
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    Diabetes drug trial needs to widen participants to understand full impact of drugs Empty Re: Diabetes drug trial needs to widen participants to understand full impact of drugs

    Post by chris c Mon Jul 17 2017, 23:24

    Someone described these drugs as "low carb in a pill" because they basically pump the excess glucose out of the body through the kidneys without increasing or maybe even decreasing insulin levels. So they may have a similar effect to not putting the glucose into the body in the first place. Which as any dietician will tell you is highly dangerous and your brain will die.
    graham64
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    Diabetes drug trial needs to widen participants to understand full impact of drugs Empty Re: Diabetes drug trial needs to widen participants to understand full impact of drugs

    Post by graham64 Tue Jul 18 2017, 22:33

    chris c wrote:Someone described these drugs as "low carb in a pill" because they basically pump the excess glucose out of the body through the kidneys without increasing or maybe even decreasing insulin levels. So they may have a similar effect to not putting the glucose into the body in the first place. Which as any dietician will tell you is highly dangerous and your brain will die.

    They do come with some serious side effects such as ketoacidosis and increased bladder cancer risk, got to be safer than low carb though. 

    Worrying times when dietitians are actually involved in advising medics on medication doses... 

    https://twitter.com/RD_Catherine/status/887360236641767424
    chris c
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    Diabetes drug trial needs to widen participants to understand full impact of drugs Empty Re: Diabetes drug trial needs to widen participants to understand full impact of drugs

    Post by chris c Wed Jul 19 2017, 22:31

    Oh that's going to be scary, now they can prescribe the harm with one hand and the cure with the other.

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    Diabetes drug trial needs to widen participants to understand full impact of drugs Empty Re: Diabetes drug trial needs to widen participants to understand full impact of drugs

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