Medicines and Vegetable Oils as Hidden Causes of Cardiovascular Disease and Diabetes

Background: Positive associations have been observed between cardiovascular disease (CVD) and type 2 diabetes mellitus (DM), but their causal relationship has not been clarified. Nevertheless, guidelines from relevant medical societies recommend using cholesterol lowering medication (statin) for both types of patients.

Medicines with several different action mechanisms have been developed, and the effectiveness of different lifestyle modifications has been studied extensively for the prevention of DM, which was successful in improving clinical marker status in relatively short-term treatments, but none have been shown to be effective in improving long-term outcomes (mortality from CVD and all causes).

Summary: Statin-induced suppression of prenyl intermediates in the cholesterol biosynthetic pathway has been linked to stimulated atherosclerosis and heart failure. On the other hand, certain types of vegetable oil and hydrogenated oil shortened the survival of stroke-prone spontaneously hypertensive rats by decreasing platelet number, increasing hemorrhagic tendency and damaging kidney functions, which could not be accounted for by their fatty acid and phytosterol compositions.

These vegetable oils and medicines such as statin and warfarin share, in part, a common mechanism to inhibit vitamin K2-dependent processes, which was interpreted to lead to increased onset of CVD, DM, chronic kidney disease, bone fracture and even mental disorder. Impaired vitamin K2-dependent processes by some types of vegetable oils and medicines, but not plasma high low density lipoprotein cholesterol, were proposed as the cause of CVD, DM and other lifestyle-related diseases.

High n-6/n-3 fatty acid ratio of ingested foods, but not animal fats, was emphasized to be another risk factor for many of the diseases described above. Key Messages: To date, no randomized controlled trials (RCTs) have been performed to prove the above interpretation. However, the opposite types of RCT trials have been performed by increasing the intake of high-linoleic vegetable oils and reducing that of animal fats, which resulted in increased CVD and all-cause mortality. The amounts of these vegetable oils to exhibit adverse effects in animal studies are not huge (<6 energy %), which should not be overlooked nor disregarded.

Full text: http://www.karger.com/Article/FullText/446704

Looks interesting! This ties in with a load of stuff I've read, from blog discussions to other studies. 

Before he joined The Establishment and deleted a lot of his posts, Stephan Guyenet came up with an interesting theory. Early studies like the Rose Corn Oil trial showed a bad result from Omega 6 oils. He hypothesised that once Omega 6 intake reaches some level which has been exceeded in modern diets, it begins to have deleterious effects on the metabolism of other fats, which explains the studies where adding MORE Omega 6 was better than adding other fats.

K2 is deeply interesting, alongside D3.

Statins and Warfarin as vit k antagonists cause arterial calcification. I do look and wonder if they take in all other causes of death when they calculate the benefits of a medication.
I reckon those two meds knackered my liver!
Derek

Derek wrote:Statins and Warfarin as vit k antagonists cause arterial calcification.  I do look and wonder if they take in all other causes of death when they calculate the benefits of a medication.
I reckon those two meds knackered my liver!
Derek

Conventional Medicine is the Leading Cause of Death  https://draxe.com/conventional-medicine-is-the-leading-cause-of-death/

When most medics and dietitians can't get close to a safe diet for a diabetic, what can we expect? They recommend a diet of slow death, with as much big pharma medication as they can ram down patients necks. No money in healthy people, no money in dead people, the money is in keeping people alive.....sort of. And the real irony is, we don't allow euthanasia in the UK. You couldn't make it up. What we need is around 10 million pensioners killed off as swiftly as possible. Then around 10 million low paid, zero skilled, zero hours immigrants coming into the UK. OK, forget it, the big chiefs have already thought of that scheme.  I know, how about WW3 and at least 50 million dead, Jeez, they are working hard on that one too.

Without a doubt, old timers like me had the best 50 years this country will ever see. Never ever out of work, no Uni fees, so easy to buy a home. A strong NHS, kids going to the school of our choice and a Police force in control. When I rant on my kids fall about laughing, here the old fool goes again they think, if only they knew what this country used to be.

Ah well, all good things must come to an end. Back to reading The Angling Times. Meeting up with Graham on Wednesday for a meal and a drink, another night of fillet steak, copious booze and liver bashing. This low carb lark is a tough gig, but us old-timers can take it.  

(Vegetables oil aren't just a problem because of omega 6/ omega 3 ratio, but because they produce toxic metabolites when heated.)

"Professor Grootveld’s team found sunflower oil and corn oil produced aldehydes at levels 20 times higher than recommended by the World Health Organisation. 

Olive oil and rapeseed oil produced far fewer aldehydes as did butter and goose fat.

Not only that, but Professor Grootveld's team also identified two previously unknown aldehydes in the samples of these oils - a world first.

He said: “Sunflower and corn oil are fine as long as you don't subject them to heat, such as frying or cooking. It's a simple chemical fact that something which is thought to be healthy for us is converted into something that is very unhealthy at standard frying temperatures." "

http://www.dmu.ac.uk/about-dmu/news/2015/july/dmu-research-on-healthiest-cooking-oils-revealed-on-bbcs-trust-me,-im-a-doctor.aspx

Of course flax seed oil should not be heated. I wonder, are there any problems for us cooking ground flax? regards Derek

The breakdown gets worse when these oils are reheated over and over, as in commercial fryers. Never happened back in the day when your fish and chips were fried in lard or beef dripping.

The BDA's take on fats

Try replacing some of the less healthy fats
with these:

Unsaturated fats/oils – found generally in plant foods such as seeds/grains, nuts, vegetables and fruit.They can be either polyunsaturated, found in sunflower, soya, corn, and sesame oils or monounsaturated like olive and rapeseed oils. Evidence suggests that the inclusion of the monounsaturated fats are particularly good as they help to promote the healthier type of
cholesterol in our blood. Include these in your diet by using small amounts of the oils to cook with (instead of lard or butter), in salad dressings, or as spreading fats. Almonds, hazelnuts and peanuts are rich sources of monounsaturated fats and if eaten unsalted, just a small daily handful would contribute towards a healthy diet. Fortified spreading fats will provide us with small amounts of vitamins A and D.

https://www.bda.uk.com/foodfacts/FatFacts.pdf

Then again these clowns at the BDA state: "People with diabetes should eat a healthy diet, the same as somebody without diabetes"  

They use the Eat Well guide in their diabetes fact sheet meaning 38% should be derived from starch yet they talk about the importance of good blood glucose control

https://www.bda.uk.com/foodfacts/diabetestype2.pdf

They are probably right about the monounsaturates, and that's as far as I'll go. They're too dumb to notice that their "healthy diet" is making most of the population obese and/or ill. Still it's making them rich, look at their sponsors, same sponsors as DUK, the ADA etc.