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    More Science, Can You Believe It?

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    chris c
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    Re: More Science, Can You Believe It?

    Post by chris c on Thu Sep 06 2018, 23:36

    Oh yes that's an excellent one, here

    http://sci-hub.tw/10.1002/jcla.22650

    There's just so much of it now

    Relationship between very low low-density
    lipoprotein cholesterol concentrations not
    due to statin therapy and risk of type 2
    diabetes: A US-based cross-sectional
    observational study using electronic health
    records

    https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002642

    "Very low LDL-C concentrations occurring in the absence of statin treatment were significantly associated with T2DM risk in a large EHR population; this increased risk was present in both sexes and all BMI categories, and in individuals of European ancestry but not of African ancestry. Longitudinal cohort studies to assess the relationship between very low LDL-C levels not associated with lipid-lowering therapy and risk of developing T2DM will be important."

    oops!

    Remission of pre-diabetes to normal
    glucose tolerance in obese adults with
    high protein versus high carbohydrate
    diet: randomized control trial

    https://drc.bmj.com/content/4/1/e000258

    Still a bit afraid of the fat, but even cutting carbs to 40% seems to help

    Comparison of endothelial progenitor cell
    function in type 2 diabetes with good and poor
    glycemic control

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858721/

    "Conclusion

    There was EPC dysfunction in type 2 diabetes which might be improved by strict glycemic control. However, the circulating EPC number and proliferative function in patients with good glycemic control did not reach the level in healthy controls."

    I suspect that may be due to the way control was achieved. Low carb good, jacking up insulin bad. Just a thought. Ties in with much of Malcolm Kendrick's work.

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    graham64
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    Re: More Science, Can You Believe It?

    Post by graham64 on Sun Sep 09 2018, 22:49

    This study was done eight years ago and don't think there have been any other studies that contradict it

    Markers of cardiovascular risk are not changed by increased whole-grain intake: the WHOLEheart study, a randomised, controlled dietary intervention

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501710/

    More recently and one which dietitians must hate 

    Whole grain cereals for the primary or secondary prevention of cardiovascular disease.

    https://www.ncbi.nlm.nih.gov/pubmed/28836672


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    Proving the LowCarb sceptics wrong for over ten years

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    Re: More Science, Can You Believe It?

    Post by chris c on Mon Sep 10 2018, 23:16

    That first one contained Susan Jebb. oops!

    Yes the Cochrane one didn't go down so well.

    Where are the studies of whole grains vs. NO grains?

    https://isupportgary.com/articles/seventh-day-adventist-plant-based-nutrition

    https://isupportgary.com/articles/cereal-catalyst-lifestyle-medicine-vegan

    Role Of Sugars in Human Neutrophilic Phagocytosis - from 1973

    http://sci-hub.tw/10.1093/ajcn/26.11.1180

    Risk Factors, Mortality, and Cardiovascular
    Outcomes in Patients with Type 2 Diabetes

    http://sci-hub.tw/10.1056/NEJMoa1800256

    Association between insulin resistance
    and the development of cardiovascular disease

    https://cardiab.biomedcentral.com/articles/10.1186/s12933-018-0762-4

    pdf available

    The Food Supply Of The Future (from 1909)

    https://www.jstor.org/stable/pdf/1634378.pdf

    Output and technical change in twentieth-century
    British agriculture

    http://www.bahs.org.uk/AGHR/ARTICLES/48n1a4.pdf

    long but interesting

    and another excellent takedown of Harvard/Lancet rubbish

    https://www.psychologytoday.com/us/blog/diagnosis-diet/201809/latest-low-carb-study-all-politics-no-science
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    graham64
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    Re: More Science, Can You Believe It?

    Post by graham64 on Tue Sep 11 2018, 22:21

    ASSOCIATIONS BETWEEN TRIGLYCERIDE/HIGH-DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND MICRO- AND MACROANGIOPATHIES IN TYPE 2 DIABETES MELLITUS

    Conclusion: A high TG/HDL-C ratio was significantly associated with albuminuria, CAD, CVA, and peripheral artery occlusive disease (PAOD) in patients with DM, which translated into an increased risk of cardiovascular disease.

    http://journals.aace.com/doi/abs/10.4158/EP-2017-0254?code=aace-site&journalCode=endp

    Another earlier study stressing the importance TG/HDL ratio

    The Association between Triglyceride/High-Density Lipoprotein Cholesterol Ratio and All-Cause Mortality in Acute Coronary Syndrome after Coronary Revascularization

    https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123521

    Of course we know how to lower trigs and raise HDL don't we  Wink

    Meanwhile found on twitter via Ivor, new from Uffe Ravnskov

    LDL-C Does Not Cause Cardiovascular Disease: a comprehensive review of current literature

    Expert commentary

    Our search for falsifications of the cholesterol hypothesis confirms that it is unable to satisfy any of the Bradford Hill criteria for causality, and that the conclusions of the authors of the three reviews are based on misleading statistics, exclusion of unsuccessful trials and by ignoring numerous contradictory observations.

    https://www.tandfonline.com/doi/abs/10.1080/17512433.2018.1519391


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    Proving the LowCarb sceptics wrong for over ten years

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
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    Re: More Science, Can You Believe It?

    Post by chris c on Fri Sep 14 2018, 23:29

    Damn, the first paper isn't on Sci-Hub (yet) but the Ravnskov one is

    https://doi.org/10.1080/17512433.2018.1519391

    It's getting to the state where the only people who don't know this stuff have their fingers in their ears.

    Meanwhile Jennifer Elliott is back blogging again

    http://blog.babyboomersandbellies.com

    and here's one of her papers

    Flaws, Fallacies and Facts: Reviewing the
    Early History of the Lipid and Diet/Heart
    Hypotheses

    http://file.scirp.org/Html/7-2701370_50455.htm

    no wonder they had to deregister her
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    graham64
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    Re: More Science, Can You Believe It?

    Post by graham64 on Sun Sep 16 2018, 22:32

    Just from the abstract of the Uffe Ravnskov paper it's plain to see were he's coming from, wonder if Professor Statin has read it yet  Question


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    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over ten years

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
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    graham64
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    Re: More Science, Can You Believe It?

    Post by graham64 on Sun Sep 16 2018, 22:49

    Another paper from Nicola Guess, she seems to be one of the saner ones who's prepared to consider diets other than low fat 

    Dietary Interventions for the Prevention of Type 2 Diabetes in High-Risk Groups: Current State of Evidence and Future Research Needs

    Abstract: A series of large-scale randomised controlled trials have demonstrated the effectiveness of lifestyle change in preventing type 2 diabetes in people with impaired glucose tolerance. Participants in these trials consumed a low-fat diet, lost a moderate amount of weight and/or increased their physical activity. Weight loss appears to be the primary driver of type 2 diabetes risk reduction, with individual dietary components playing a minor role. The effect of weight loss via other dietary approaches, such as low-carbohydrate diets, a Mediterranean dietary pattern, intermittent fasting or very-low-energy diets, on the incidence of type 2 diabetes has not been tested. These diets—as described here—could be equally, if not more effective in preventing type 2 diabetes than the tested low-fat diet, and if so, would increase choice for patients. There is also a need to understand the effect of foods and diets on beta-cell function, as the available evidence suggests moderate weight loss, as achieved in the diabetes prevention trials, improves insulin sensitivity but not beta-cell function. Finally, prediabetes is an umbrella term for different prediabetic states, each with distinct underlying pathophysiology. The limited data available question whether moderate weight loss is effective at preventing type 2 diabetes in each of the prediabetes subtypes.

    http://www.mdpi.com/2072-6643/10/9/1245/htm

    Obviously a moderate weight loss would not have prevented my diabetes  Sad


    _________________
    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over ten years

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
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    chris c
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    Re: More Science, Can You Believe It?

    Post by chris c Yesterday at 23:14

    Nor mine, nor that of about 20% of other "Type 2"s.

    I can't decide about her, she's less clueless than the other reprobates but still has a long way to go. A while back she was stating that there was "no evidence" other than made up stuff on blogs about the harms from Omega 6 oils, and Tucker Goodrich kindly pointed her to not just a paper but an entire ISSUE of a journal on the subject. It's hard to do evidence-based medicine when you aren't told about half the evidence.

    Still she's moving in the right direction. I think the next step will be

    "Well if you really can't make a healthy low fat/Mediterranean?vegan diet work perhaps it wouldn't do any harm to try a low carb diet, but only for six months"

    To us it's woeful but to them it's a major step.

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    Re: More Science, Can You Believe It?

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