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    More Science, Can You Believe It?

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    chris c
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    More Science, Can You Believe It?

    Post by chris c on Sun Mar 11 2018, 23:05

    Saturated fat does not clog the arteries: coronary heart disease is a chronic inflammatory condition, the risk of which can be effectively reduced from healthy lifestyle interventions

    http://bjsm.bmj.com/content/51/15/1111

    Designed by the food industry for
    wealth, not health: the ‘Eatwell Guide’
    Zoe Harcombe

    http://sci-hub.hk/10.1136/bjsports-2016-096297

    Meat in the post-truth era: Mass media discourses on health and disease in the
    attention economy

    http://sci-hub.hk/10.1016/j.appet.2018.02.028

    "The debate on meat’s role in health and disease is a rowdy and dissonant one. This study uses the
    health section of the online version of The Daily Mail as a case study to carry out a quantitative and
    qualitative reflection on the related discourses in mass media during the first fifteen years of the 21
    st century. "

    "The narratives were often histrionic and displayed
    serious contradictions. Since several interests were at play, involving a variety of input from
    dieticians, (health) authorities, the food industry, vegan or vegetarian movements, and celebrities,
    the overall discourse was highly heterogeneous. "

    The Evolving Hypothesis of Obesity – the role of polyunsaturated fats

    http://www.lchf-rd.com/2018/03/07/a-new-hypothesis-for-obesity-part1/

    I have a lot of time for Joy Kidde because she noticed in the nick of time that her diet had made her fat and ill, and she set out to do something about it.

    This and the following blog post are from a talk by Michael Eades who has been way ahead of his time for decades. The likes of Tucker Goodrich and Peter at Hyperlipid have also been digging into the excess Omega 6 issue, and the fact that the Angry Chef thinks it is bollocks makes it even more likely to be true. (strange how his blog and twitter account went dark once his book was published, eh?)
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    Re: More Science, Can You Believe It?

    Post by graham64 on Mon Mar 12 2018, 22:11

    @chris c wrote:Saturated fat does not clog the arteries: coronary heart disease is a chronic inflammatory condition, the risk of which can be effectively reduced from healthy lifestyle interventions

    http://bjsm.bmj.com/content/51/15/1111

    Designed by the food industry for
    wealth, not health: the ‘Eatwell Guide’
    Zoe Harcombe

    http://sci-hub.hk/10.1136/bjsports-2016-096297

    Meat in the post-truth era: Mass media discourses on health and disease in the
    attention economy

    http://sci-hub.hk/10.1016/j.appet.2018.02.028

    "The debate on meat’s role in health and disease is a rowdy and dissonant one. This study uses the
    health section of the online version of The Daily Mail as a case study to carry out a quantitative and
    qualitative reflection on the related discourses in mass media during the first fifteen years of the 21
    st century. "

    "The narratives were often histrionic and displayed
    serious contradictions. Since several interests were at play, involving a variety of input from
    dieticians, (health) authorities, the food industry, vegan or vegetarian movements, and celebrities,
    the overall discourse was highly heterogeneous. "

    The Evolving Hypothesis of Obesity – the role of polyunsaturated fats

    http://www.lchf-rd.com/2018/03/07/a-new-hypothesis-for-obesity-part1/

    I have a lot of time for Joy Kidde because she noticed in the nick of time that her diet had made her fat and ill, and she set out to do something about it.

    This and the following blog post are from a talk by Michael Eades who has been way ahead of his time for decades. The likes of Tucker Goodrich and Peter at Hyperlipid have also been digging into the excess Omega 6 issue, and the fact that the Angry Chef thinks it is bollocks makes it even more likely to be true. (strange how his blog and twitter account went dark once his book was published, eh?)

    I had noticed the Angry Chef has been quiet of late also no tweets from his adoring BDA dietitian friends about him, wonder if his view on vegan diets is the reason: https://www.thetimes.co.uk/article/the-angry-chef-the-dangers-of-a-vegan-diet-583c2wbgs

    He has got a mention here though: https://twitter.com/CerealKillers13/status/973195200628776960


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    Re: More Science, Can You Believe It?

    Post by graham64 on Tue Mar 13 2018, 21:42

    Intake of dietary saturated fatty acids and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition-Netherlands cohort: associations by types, sources of fatty acids and substitution by macronutrients

    Full text: https://link.springer.com/article/10.1007/s00394-018-1630-4

    Dairy Fats and Cardiovascular Disease: Do We Really Need to be Concerned?

    Full text: http://www.mdpi.com/2304-8158/7/3/29/htm


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    Proving the LowCarb sceptics wrong for over ten years

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
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    Re: More Science, Can You Believe It?

    Post by chris c on Tue Mar 13 2018, 22:58

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    Re: More Science, Can You Believe It?

    Post by chris c on Tue Mar 13 2018, 23:05

    Oh a couple more

    Study of the Use of Lipid Panels as a Marker of Insulin Resistance to Determine Cardiovascular Risk

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625988/

    "Conclusion:
    Insulin resistance, as manifested by a high triglyceride/HDL-c ratio, was associated with adverse cardiovascular outcomes more than other lipid metrics, including LDL-c, which had little concordance. Physicians and patients should not overlook the triglyceride/HDL-c ratio."

    Mine went from nearly seven to under one and stayed there. Low carb tends to do that as you probably noticed.

    Prevalence trends tell us what did not precipitate the US obesity epidemic

    http://www.thelancet.com/journals/lanpub/article/PIIS2468-2667%2818%2930021-5/fulltext

    "The increases in the prevalence of obesity began in the late 1970s across the whole US population.5 The speed and extent of weight gain varied somewhat by age, sex and ethnicity5 but for all subgroups most people became heavier at about the same time. This simple observation indicates something important about factors that did not precipitate the US obesity epidemic. We believe it is implausible that each age, sex and ethnic group, with massive differences in life experience and attitudes, had a simultaneous decline in willpower related to healthy nutrition or exercise. "

    I'll read your papers later.
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    Re: More Science, Can You Believe It?

    Post by chris c on Thu Mar 15 2018, 21:54

    Good stuff, thanks!

    More on cheese etc. from Dariush Mozaffarian

    Flavonoids, Dairy Foods, and Cardiovascular
    and Metabolic Health
    A Review of Emerging Biologic Pathways

    http://circres.ahajournals.org/content/circresaha/122/2/369.full.pdf?ijkey=yS0CIv0gfwp0UYM&keytype=ref

    Glucose patterns during an oral glucose tolerance test
    and associations with future diabetes, cardiovascular disease
    and all-cause mortality rate

    http://sci-hub.hk/10.1007/s00125-017-4468-z

    haven't read that one yet
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    Re: More Science, Can You Believe It?

    Post by chris c on Thu Mar 15 2018, 22:04

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    Re: More Science, Can You Believe It?

    Post by graham64 on Fri Mar 16 2018, 22:27

    Interesting article on the use of carnosine supplements in diabetes prevention

    Have we got the causes of type 2 diabetes wrong?

    https://theconversation.com/have-we-got-the-causes-of-type-2-diabetes-wrong-93326


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    Proving the LowCarb sceptics wrong for over ten years

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    Re: More Science, Can You Believe It?

    Post by yoly on Sat Mar 17 2018, 15:08

    @graham64 wrote:Interesting article on the use of carnosine supplements in diabetes prevention

    Have we got the causes of type 2 diabetes wrong?

    https://theconversation.com/have-we-got-the-causes-of-type-2-diabetes-wrong-93326

    Interesting but in fruit flies, they could have tried to expand to mice before publishing. The other think is in all the articles they always mention control and complications. What they call control is really not control and they now have increased further to A1C over 8%. And they never mention the other big elephant in the room insulin.
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    Re: More Science, Can You Believe It?

    Post by chris c on Sat Mar 17 2018, 19:55

    Correlation between dietary changes and disease incidence are generating more critical studies of the effects of excess Omega 6 oils and the nasty things they degenerate into after being eaten and especially when heated. Tucker Goodrich among others has amassed a bunch of studies on this.

    This may be one more factor in overgenerating insulin resistance along with the recommended carbs. Also the damage from excess glucose may be amplified.

    Just a thought, where would you find carnosine? Meat?

    Yeah, what they call "controlled" diabetes isn't, and "controlling" glucose with extra insulin doesn't help much either.

    Remember EPIC-Norfolk?

    http://sci-hub.hk/10.1097/MOL.0b013e3280106b95

    would be even more interesting if they had also studied insulin levels.
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    Re: More Science, Can You Believe It?

    Post by graham64 on Sat Mar 17 2018, 22:55

    @yoly wrote:
    @graham64 wrote:Interesting article on the use of carnosine supplements in diabetes prevention

    Have we got the causes of type 2 diabetes wrong?

    https://theconversation.com/have-we-got-the-causes-of-type-2-diabetes-wrong-93326

    Interesting but in fruit flies, they could have tried to expand to mice before publishing. The other think is in all the articles they always mention control and complications. What they call control is really not control and they now have increased further to A1C over 8%. And they never mention the other big elephant in the room insulin.

    They have done a pilot clinical trial on people:  https://onlinelibrary.wiley.com/doi/full/10.1002/oby.21434


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    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over ten years

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
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    Re: More Science, Can You Believe It?

    Post by graham64 on Sat Mar 17 2018, 23:05

    @chris c wrote:Correlation between dietary changes and disease incidence are generating more critical studies of the effects of excess Omega 6 oils and the nasty things they degenerate into after being eaten and especially when heated. Tucker Goodrich among others has amassed a bunch of studies on this.

    This may be one more factor in overgenerating insulin resistance along with the recommended carbs. Also the damage from excess glucose may be amplified.

    Just a thought, where would you find carnosine? Meat?

    Yeah, what they call "controlled" diabetes isn't, and "controlling" glucose with extra insulin doesn't help much either.

    Remember EPIC-Norfolk?

    http://sci-hub.hk/10.1097/MOL.0b013e3280106b95

    would be even more interesting if they had also studied insulin levels.

    Got to be worth a try Chris far better than the latest diabetes prevention advice from DUK 

    To prevent diabetes, people are advised to eat more wholegrains and fruit and vegetables - particularly apples, grapes, blueberries and green leafy vegetables.

    http://www.dailymail.co.uk/health/article-5508723/The-diabetes-prevention-diet.html


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    Proving the LowCarb sceptics wrong for over ten years

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
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    Re: More Science, Can You Believe It?

    Post by yoly on Mon Mar 19 2018, 09:34

    Is well known for a long time that many natural products used for diabetes reduce methylglyoxal. Eating less carbohydrates also reduce the production of it. Carnosine as a supplement is expensive and the limit factor in the production of carnosine is beta alanine which is cheap and have been proven that increase carnosine levels. I never found any difference using carnosine or beta alanine, but it may work in some in prevention.
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    Re: More Science, Can You Believe It?

    Post by chris c on Mon Mar 19 2018, 20:51

    Well I think the rump steak I just ate (with broccoli) probably gave me a goodly dose of carnosine.

    Meanwhile

    Glucose patterns during an oral glucose tolerance test
    and associations with future diabetes, cardiovascular disease
    and all-cause mortality rate

    http://sci-hub.hk/10.1007/s00125-017-4468-z

    "Conclusions/interpretation Elevated 30 min glucose is associated
    with increased risk of diabetes and all-cause mortality
    rate independent of fasting and 2 h glucose levels. Therefore,
    subgroups at high risk may not be revealed when considering
    only fasting and 2 h glucose levels during an OGT"

    Kraft would also have tested insulin which would have helped.

    Comparison of a carbohydrate-free diet vs. fasting
    on plasma glucose, insulin and glucagon in
    type 2 diabetes

    http://sci-hub.hk/10.1016/j.metabol.2014.10.004

    Still working, it was a couple of decades back they did their infamous LoBAG (Low Biologically Active Glucose) studies for the ADA

    Involvement of steatosis-induced glucagon resistance
    in hyperglucagonaemia

    http://sci-hub.hk/https://doi.org/10.1016/j.mehy.2015.10.029

    "Hypothesis
    We hypothesise that in the majority of individuals with type 2
    diabetes hepatic sensitivity to glucagon is compromised due to
    hepatic steatosis, and that this provides a feedback mechanism acting
    at the level of pancreatic alpha cells, leading to hyperglucagonaemia.
    This would explain the hyperglucagonaemia often seen in
    diabetic subjects as a compensatory mechanism."

    A halfway house between Roger Unger and Roy Taylor. I've also seen studies on the blocking of communication between the pancreatic alpha and beta cells.

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    Re: More Science, Can You Believe It?

    Post by chris c on Fri Mar 23 2018, 23:31

    This was good to see in a mainstream source

    https://www.medscape.com/viewarticle/894041_1

    (you need to register but they have never spammed me in well over a decade)

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    Re: More Science, Can You Believe It?

    Post by graham64 on Sun Mar 25 2018, 22:15

    @chris c wrote:This was good to see in a mainstream source

    https://www.medscape.com/viewarticle/894041_1

    (you need to register but they have never spammed me in well over a decade)


    Yes I registered a few years ago and you do get occasional good articles as your link showed, interesting comments with a mixed response.   

    This link may work for anybody not registered I got it by going incognito

    Ketogenic Diet: Which Patients Benefit?

    https://www.medscape.com/viewarticle/894041


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    Re: More Science, Can You Believe It?

    Post by chris c on Sun Mar 25 2018, 22:54

    Another

    New Diabetes UK Nutrition Guidance Supports Individual Approach

    https://www.medscape.com/viewarticle/893969

    This is the sort of thing doctors might read

    compare and contrast

    https://web.archive.org/web/20040203222331/http://www.diabetes.org/nutrition-and-recipes/nutrition/starches.jsp


    I have more, from William Barendse at CSIRO

    Should animal fats be back on the table? A critical review
    of the human health effects of animal fat

    http://www.publish.csiro.au/an/pdf/AN13536

    Randomised trial of coconut oil, olive
    oil or butter on blood lipids and other
    cardiovascular risk factors in healthy
    men and women

    http://bmjopen.bmj.com/content/8/3/e020167

    so maybe that instantly lethal coconut oil isn't

    Low calorie and low carb diets for weight loss in primary care

    http://www.bmj.com/content/360/bmj.k1122

    not entirely sure about this one, still too much emphasis on "calories" not carbs

    Then there's this from the estimable Peter

    http://high-fat-nutrition.blogspot.co.uk/2018/02/registered-dietitian-health-educators.html
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    Re: More Science, Can You Believe It?

    Post by graham64 on Sun Mar 25 2018, 23:20

    Just read the Medscape article Chris did you see Duane Mellor's declarations  Question

    New Diabetes UK Nutrition Guidance Supports Individual Approach

    Duane Mellor declared funding from or consultancy to multiple pharmaceutical companies and food companies.

    https://www.medscape.com/viewarticle/893969#vp_3


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    Proving the LowCarb sceptics wrong for over ten years

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
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    Re: More Science, Can You Believe It?

    Post by chris c on Thu Mar 29 2018, 00:39

    Goes without saying!

    (What does? I don't know, it went without saying! RIP Spike Milligan)

    A network meta-analysis on the comparative efficacy of different
    dietary approaches on glycaemic control in patients with type 2
    diabetes mellitus

    https://link.springer.com/content/pdf/10.1007/s10654-017-0352-x.pdf

    It's a step from outright condemning low carb to finding that it may be comparable to other diets.

    Glycated Hemoglobin Level Is Strongly Related to the Prevalence of Carotid Artery Plaques With High Echogenicity in Nondiabetic Individuals

    http://circ.ahajournals.org/content/110/4/466.long

    backs up EPIC-Norfolk and the huge New Zealand studies and provides a possible mechanism

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    Re: More Science, Can You Believe It?

    Post by chris c on Wed Apr 04 2018, 17:54

    Food sources of fat may clarify the inconsistent role of dietary fat intake for incidence of type 2 diabetes

    https://academic.oup.com/ajcn/article/101/5/1065/4577562

    Prospective associations of dietary carbohydrate, fat, and protein intake with β-cell function in the CODAM study

    https://link.springer.com/article/10.1007/s00394-018-1644-y

    you can get the pdf

    Surgical vs Lifestyle Treatment
    for Type 2 Diabetes

    an interesting concept for a study from David Ludwig

    http://sci-hub.hk/10.1001/2012.jama.10156
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    Re: More Science, Can You Believe It?

    Post by yoly on Thu Apr 05 2018, 11:09

    They can't be so dumb. Money and conformity have to play a big role in so much dumb advice. Even a kid can figure out that if you have a problem of too much of something (glucose) the first thing to try have to be reducing the intake of what is causing the problem. You don't need to be a genius to figure that one out.
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    Re: More Science, Can You Believe It?

    Post by chris c on Fri Apr 06 2018, 22:03

    Oh but glucose is plant based so it can't be harmful unlike animals.
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    Re: More Science, Can You Believe It?

    Post by graham64 on Fri Apr 20 2018, 23:33

    Can't remember if this has been posted before 

    Replacement of saturated and trans-fatty acids in the diet v. CVD risk in the light of the most recent studies

    Conclusions
    It is extremely difficult to extrapolate results of recent studies to contemporary recommendations. It seems that there is a need for properly randomised studies on large groups, with good control of dietary and non-dietary parameters, which account for not only the sum of SFA and TFA, but also their source. Only such studies will allow for full evaluation of an effect of substituting SFA and TFA on cardiovascular risk.

    https://www.cambridge.org/core/journals/public-health-nutrition/article/replacement-of-saturated-and-transfatty-acids-in-the-diet-v-cvd-risk-in-the-light-of-the-most-recent-studies/4EBAEA6A87CF873794CD14474AB350D8

    This is an old paper I found on twitter 

    Gallbladder motility and gallstone formation in obese patients following very low calorie diets. Use it (fat) to lose it (well)

    CONCLUSION: In the obese during rapid weight loss from a very low calorie diet, a relatively high fat intake could prevent gallstone formation, probably by maintaining an adequate gallbladder emptying, which could counterbalance lithogenic mechanisms acting during weight loss.

    https://www.nature.com/articles/0800634


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    Re: More Science, Can You Believe It?

    Post by chris c on Sat Apr 21 2018, 00:00

    The Cambridge Core article

    http://sci-hub.hk/10.1017/S1368980018000782

    The consultant I saw about my gallstones was pretty clueful in many ways, he had almost worked out Metabolic Syndrome and epigenetics back in the eighties, but was still convinced dietary fat was to blame.

    It was Michael Eades, so often ahead of the game, who made me realise it was the LACK of fat that caused the gallstones, hence why they became so much more common and spread to different populations - more males and younger people - since low fat diets were invented.
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    Re: More Science, Can You Believe It?

    Post by chris c on Sun Apr 22 2018, 21:06

    Plasma 25-hydroxyvitamin D concentration and risk of type 2 diabetes and pre-diabetes: 12-year cohort study

    http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193070

    I've also seen Vitamin D related to Type 1 which is commoner nearer to the poles, along with other autoimmune diseases.

    Detection, monitoring, and
    deleterious health effects of
    lipid oxidation products generated
    in culinary oils during thermal
    stressing episodes

    https://www.researchgate.net/profile/Martin_Grootveld3/publication/286130246_Detection_monitoring_and_deleterious_health_effects_of_lipid_oxidation_products_generated_in_culinary_oils_during_thermal_stressing_episodes/links/571105ef08ae4ef74524aa66/Detection-monitoring-and-deleterious-health-effects-of-lipid-oxidation-products-generated-in-culinary-oils-during-thermal-stressing-episodes.pdf

    More on those "healthy" vegetable oils

    All obese individuals are not created equal:
    insulin resistance is the major determinant
    of cardiovascular disease in
    overweight/obese individuals
    GERALD REAVEN

    http://journals.sagepub.com/doi/pdf/10.3132/dvdr.2005.017

    thanks to Verner Wheelock for that one

    Why Cholesterol Levels Have No Effect on Cardiovascular Disease [transcript]

    http://www.nourishbalancethrive.com/blog/2018/04/16/why-cholesterol-levels-have-no-effect-cardiovascular-disease-transcript/

    an interview with Malcolm Kendrick

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