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    More Science, Can You Believe It?

    chris c
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    Post by chris c on Thu Nov 01 2018, 22:35

    I'll read that later after I've eaten some cheese.
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    Post by graham64 on Fri Nov 02 2018, 22:44

    Spotted this on twitter unfortunately the full text is not available yet 

     High low-density lipoprotein cholesterol inversely relates to dementia in community-dwelling older adults

    Abstract

    Background: The relationship between cholesterol and cognitive function is unclear from the previous studies. This study was conducted to explore this association in older Chinese adults.

    Methods: Data were from the Shanghai Aging Study, comprising 3836 residents aged 50 years or over in an urban community. Diagnoses of dementia and mild cognitive impairment were established according to the fourth edition of diagnostic and statistical manual of mental disorders (DSM-IV) and Petersen criteria. Multivariate logistic regression models, non-matched and propensity score (PS) matched, were used to examine the association between cholesterol levels and cognitive function.

    Results: There was a significantly higher proportion of participants with low levels of total cholesterol (TC) and low density lipoprotein cholesterol(LDL-C) in the dementia group than in groups without dementia (P<0.05). High LDL-C level was inversely associated with dementia, with a negative trend in the PS matched model. TC and high density lipoprotein cholesterol (HDL-C) were not significantly related to dementia in either non-matched models or PS matched models.

    Conclusion: Our result indicates that high level of LDL-C is inversely associated with dementia. High level of LDL-C may be considered as a potential protective factor against cognition decline.

    https://www.frontiersin.org/articles/10.3389/fneur.2018.00952/abstract

    Could statins be playing a part in increasing the risks of dementia as well


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    Proving the LowCarb sceptics wrong for over ten years

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
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    Post by chris c on Sun Nov 04 2018, 22:54

    I found the full paper here

    http://sci-hub.tw/10.3389/fneur.2018.00952

    need to read it later.

    I've actually seen statins recommended for Alzheimers. Probably washed down with Coca-Cola.

    Meanwhile, have a cow

    OF COWS AND MEN: REVIEWING THE LINK BETWEEN
    MILK FAT AND HUMAN HEALTH

    https://ecommons.cornell.edu/bitstream/handle/1813/59846/Rico%20(manu).pdf?sequence=2

    Saturated Fat: Part of a Healthy Diet
    Victoria M. Gershuni1

    http://sci-hub.tw/https://doi.org/10.1007/s13668-018-0238-x

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    Post by chris c on Fri Nov 09 2018, 00:25

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    Post by graham64 on Fri Nov 09 2018, 22:06


    The All-Party Parliamentary Group recommendations look promising, if they ever get off the ground that would go a long way to reducing the billion spent on diabetes drugs 


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    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over ten years

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
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    Post by chris c on Sun Nov 11 2018, 22:33

    From what I recall David Unwin alone is now saving over £50 000/year - and no use of expensive slop

    https://twitter.com/DrScottMurray/status/1046505750686826498

    it seems what he listed isn't the actual slop used, just a similar one.

    Did I do this one yet?

    Haemoglobin A1c even within non-diabetic level
    is a predictor of cardiovascular disease in a general
    Japanese population: the Hisayama Study

    https://cardiab.biomedcentral.com/track/pdf/10.1186/1475-2840-12-164

    follows on from some of the classic studies like EPIC-Norfolk

    Study on the levels of glycosylated lipoprotein in patients with
    coronary artery atherosclerosis

    https://sci-hub.tw/10.1002/jcla.22650

    I haven't yet psyched myself up to watch the interview of Dave Feldman and Peter Attia, in fact I probably won't, life's too short. Attia and Dayspring are all about lowering LDL, this is yet another study that shows the problem is DAMAGED LDL. It'll never catch on though, we don't have a drug for that.

    Glucagon is the key factor in the development of diabetes

    https://link.springer.com/content/pdf/10.1007%2Fs00125-016-3965-9.pdf

    another from Roger Unger et al.

    Identifying hyperinsulinaemia in the absence of impaired glucose tolerance:
    An examination of the Kraft database

    https://www.researchgate.net/publication/304535127_Identifying_hyperinsulinaemia_in_the_absence_of_impaired_glucose_tolerance_An_examination_of_the_Kraft_database

    a tribute to Joseph Kraft
    and an original

    https://pharmacistcatherinedotnet.files.wordpress.com/2017/02/kraft-1975.pdf
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    Post by graham64 on Wed Nov 14 2018, 22:49

    Just published today

    Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial

    Conclusions Consistent with the carbohydrate-insulin model, lowering dietary carbohydrate increased energy expenditure during weight loss maintenance. This metabolic effect may improve the success of obesity treatment, especially among those with high insulin secretion.

    https://www.bmj.com/content/363/bmj.k4583

    High Low-Density Lipoprotein Cholesterol Inversely Relates to Dementia in Community-Dwelling Older Adults: The Shanghai Aging Study

    Conclusion: Our result indicates that high level of LDL-C is inversely associated with dementia. High level of LDL-C may be considered as a potential protective factor against cognition decline.

    https://www.frontiersin.org/articles/10.3389/fneur.2018.00952/full?utm_source=F-NTF&utm_medium=EMLX&utm_campaign=PRD_FEOPS_20170000_ARTICLE


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    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over ten years

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
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    Post by chris c on Wed Nov 14 2018, 23:27

    Didn't you just post the second one? Are you getting demented? hahahahaha oh I see the full version has now been published

    The first one looks good, Cara Ebbeling and David Ludwig. Wait for the replies from the usual low carb antis.

    James Di Nicolantonio has been busy too

    Good Fats versus Bad Fats:
    A Comparison of Fatty Acids in the Promotion
    of Insulin Resistance, Inflammation, and Obesity

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140086/pdf/ms114_p0303.pdf
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    Post by graham64 on Fri Nov 16 2018, 22:40

    @chris c wrote:
    Didn't you just post the second one? Are you getting demented? hahahahaha


    Did I  Shocked 

    Meanwhile 

    The Failure to Measure Dietary Intake Engendered a Fictional Discourse on Diet-Disease Relations

    Summary and Conclusions
    Since its first clinical trial in the eighteenth century, the field of nutrition relied on the observable effects of an individual's dietary intake on his or her health. This scientific process led to the elimination of diet-related deficiencies and substantial improvements in public health. Nonetheless, beginning in the 1950s, the field allowed rigorous research to be obscured by the sensational but implausible results and conclusions generated by the pseudo-quantified anecdotal data generated via M-BMs. The devolution from rigorous scientific observation to anecdotal (i.e., self-reported) evidence led to a fictional discourse on diet-disease relations that resulted in both public and policy confusion, and a major loss of credibility for the nutrition sciences. We challenge the field to acknowledge the inherent flaws and empirical and theoretical refutations of M-BMs, and ensure that in the future, rigorous scientific methods (e.g., RCTs) are used to study the role of diet in chronic disease.

    https://www.frontiersin.org/articles/10.3389/fnut.2018.00105/full


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    Proving the LowCarb sceptics wrong for over ten years

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
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    Post by chris c on Fri Nov 16 2018, 22:59

    Looks like they have been reading John Ioannidis. Which is good.

    Don't worry about the other one, when you first posted it only the abstract was available, I had to find the actual study on Sci-Hub and now they've posted it complete.

    Prediabetes and
    Cardiovascular Disease
    Pathophysiology and Interventions for
    Prevention and Risk Reduction

    http://sci-hub.tw/10.1016/j.ecl.2017.10.001

    pretty good stuff and adds to the concept that by the time you are actually diagnosed with diabetes the damage has been occurring for years

    MECHANISMS OF INSULIN ACTION AND INSULIN
    RESISTANCE
    Max C. Petersen and Gerald I. Shulman

    http://sci-hub.tw/10.1152/physrev.00063.2017

    91 pages! I'm only halfway through so far
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    Post by graham64 on Fri Nov 16 2018, 23:06

    @chris c wrote:91 pages! I'm only halfway through so far

    I'll leave that one for you Chris maybe you could give us a short summary when you have got through it  Smile


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    Proving the LowCarb sceptics wrong for over ten years

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
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    Post by chris c on Fri Nov 16 2018, 23:20

    I might not be able to remember what with the Alzheimers.

    Actually my problem is the exact opposite, my brain is totally full of stuff I no longer need to remember but can't forget, like names of people who died, companies that went out of business and part numbers of obsolete things. I have to plough through all of that to find what I wanted to remember from yesterday. Often I can't remember people's names when I'm talking to them, then I remember just as I'm talking to the next person whose name I can't remember.

    All I can say so far is that it's complicated. Very very complicated. I might have to read it several times. See you in a few months.
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    Post by chris c on Sun Nov 18 2018, 23:08

    Still ploughing through the insulin resistance monograph, very interesting but slow going.

    Meanwhile

    High-Dose, Diazoxide-Mediated Insulin Suppression
    Boosts Weight Loss Induced by Lifestyle Intervention

    http://sci-hub.tw/10.1210/jc.2018-01147

    Diazoxide is pretty potent stuff, Do Not Try This At Home! It's more of a proof of concept study, lowering insulin increases weight loss. Who knew? Of course there's an easier way to lower insulin, it's on the tip of my tongue . . .

    "As we have shown previously, as well as in
    the current study, the actual fasting insulin levels are
    critical determinants of the degree of fat loss. It was
    observed that clinically meaningful weight loss (.10 kg)
    only occurred if fasting insulin levels were below a
    specified limit, i.e., 4.5 mU/L in the van Boekel et al. study
    (16) and 5.5 mU /L in the current study."

    Which ties in nicely with the Ebbeling/Ludwig study above and pokes a finger in the eye of the Insulin Deniers, who have been out in force

    https://twitter.com/davidludwigmd/status/1063623505797922816

    https://twitter.com/juliaoftoronto/status/1063454296392572929

    Julia Belluz is supposedly Yoni Friedhoff's main squeeze, looks like she is now in e three-way with Kevin Hall

    https://www.vox.com/science-and-health/2018/11/16/18096633/keto-low-carb-diet

    Just needs Stephan Guyenet to join in with his insulin makes you thin nonsense and she'll be airtight. Did I really write that?

    A longitudinal 20 years of follow up showed a decrease
    in the survival of heart failure patients who
    maintained low LDL cholesterol levels

    https://sci-hub.se/10.1093/qjmed/hcy043

    oops!

    I haven't read this yet

    Dietary fat: From foe to friend?

    including Walt Wallet along with Ludwig and Jeff Volek

    http://science.sciencemag.org/content/362/6416/764
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    Post by graham64 on Sun Nov 18 2018, 23:18

    @chris c wrote:I haven't read this yet

    Dietary fat: From foe to friend?

    including Walt Wallet along with Ludwig and Jeff Volek


    Who would have thunk it strange bedfellows indeed  Shocked


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    Proving the LowCarb sceptics wrong for over ten years

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
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    Post by chris c on Sun Nov 18 2018, 23:21

    I'm not sure if Willett has actually retired or not. Maybe he tried his Gorilla Diet of 83 portions of fruit and veg a day and decided he was deluded after all.

    Earlier he wrote this

    https://varputavi.wordpress.com/2010/12/21/fat-is-not-the-problem-says-dr-walter-willett/
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    Post by chris c on Tue Nov 20 2018, 23:16

    The Disputed Science on Saturated Fats

    https://www.nutritioncoalition.us/saturated-fats-do-they-cause-heart-disease/

    How an outsider in Alzheimer’s research bucked the prevailing theory — and clawed for validation

    https://www.statnews.com/2018/10/29/alzheimers-research-outsider-bucked-prevailing-theory/

    fascinating stuff and demonstrates how hard it can be to either get research grants or publication when you step out of line.
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    Post by chris c on Thu Nov 29 2018, 23:17

    A few more, I'm not sure if the Sci-Hub links still work, it looks like it has been under attack again

    What are interesterified fats and should we
    be worried about them in our diet?

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497165/pdf/NBU-42-153.pdf

    amazing, they replace trans fats with these and have no clue what they do

    Great to see Franziska Spritzler on a comparatively mainstream site

    https://www.healthline.com/nutrition/low-carb-diet-for-diabetes

    Banting Lecture 1988
    Role of Insulin Resistance
    in Human Disease
    GERALD M. REAVEN

    http://sci-hub.tw/10.2337/diab.37.12.1595

    Lamarche, B. (1998). Fasting Insulin and Apolipoprotein B Levels and Low-Density Lipoprotein Particle Size as Risk Factors for Ischemic Heart Disease.

    http://sci-hub.tw/10.1001/jama.279.24.1955

    Twenty years later and The Anointed are still banging on as if LDL was the only relevant factor

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    Post by graham64 on Sun Dec 02 2018, 21:20

    @chris c wrote:
    Twenty years later and The Anointed are still banging on as if LDL was the only relevant factor

    But it's good for Big Pharma need to keep the statin sales up

    https://oilmarketforecast.com/2018/12/statins-market-segmentation-by-2018-2023-industry-demands-types-size-shares-revenue-with-experts-analysis/


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    Proving the LowCarb sceptics wrong for over ten years

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
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    Post by chris c on Sun Dec 02 2018, 23:19

    Astrovastatin

    hahahaha they came from outer space!

    Yes now they are mostly off patent they have to find ways of selling more to make their profits. While of course not interfering with the market for PCSK9 inhibitors.

    Maybe they'll bring back Dr Reckless - yes that really was his name - who wanted to put them in the drinking water.

    I've read some extremely obscure papers on the details involved in balancing insulin and glucagon, etc. Here's one of more relevance

    The Hypoglycemic Action of Ketones. II. Evidence for a
    Stimulatory Feedback of Ketones on the Pancreatic
    Beta Cells *

    Roger Unger et al. from way back in 1964

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC441933/pdf/jcinvest00459-0078.pdf

    OK they were using exogenous ketones rather than a keto diet, and in dogs, but

    "This combination of a ketone-induced reduction
    in blood glucose concentration during the hyperketonemia
    of starvation, coupled with a ketonemediated
    inhibition of glucose utilization by
    peripheral tissues, may not only play a role along
    with the changes in NEFA (41), growth hormone
    (34, 38), and glucagon (5) in shifting the
    fuel used for energy purposes from carbohydrate
    to fat, but also may result in the slower dissipation
    of protein precursors of glucose and thereby
    conserve glucose for use by the brain, a tissue for
    which glucose is an obligatory substrate (42).
    Such changes in metabolism would be a distinct
    advantage for survival of the organism, since
    calories stored as fat could be used for over-all
    energy without the supervention of fatal ketoacidosis
    and at the same time permit glucose,
    produced by the liver from protein precursors and
    glycerol, to be portioned out gradually under circumstances
    where its utilization by the brain
    rather than the peripheral tissues is likely to
    occur."

    Over fifty years later and a lot of people still don't know this.
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    Post by chris c on Sun Dec 09 2018, 22:42

    Lipid levels in patients hospitalized with coronary
    artery disease: An analysis of 136,905 hospitalizations
    in Get With The Guidelines

    http://sci-hub.tw/10.1016/j.ahj.2008.08.010

    thanks to Angela Stanton

    "In a large cohort of patients hospitalized with CAD,
    almost half have admission LDL <100 mg/dL, whereas less
    than a quarter have LDL N130 mg/dL. The LDL levels
    <70 mg/dL are observed in only 17.6% of patients.
    Admission HDL levels are <40 mg/dL in 54.6% of patients
    hospitalized with CAD, whereas <10% of patients have
    admission HDL levels ≥60 mg/dL"

    so obviously the LDL still has not been lowered enough <sigh>

    The antidote thanks to Tom Naughton

    Serum Cholesterol and Atherosclerosis in Man

    https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.23.6.847

    "No correlation could be observed between
    the serum cholesterol level and the amount
    and severity of atheroselerosis in the arteries."

    in 1961

    Ketogenic Diet Myths vs. Facts

    https://ninateicholz.com/ketogenic-diet-myths-vs-facts/

    Kevin Stock

    https://www.kevinstock.io/health/health-dangers-of-a-plant-based-diet/

    https://www.kevinstock.io/health/health-dangers-of-plant-based-foods/


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