l-Citrulline Supplementation: Impact on Cardiometabolic Health

l-Citrulline Supplementation: Impact on Cardiometabolic Health

Published: 19 July 2018

(full study on link)

http://www.mdpi.com/2072-6643/10/7/921/htm

Abstract:

Diminished bioavailability of nitric oxide (NO), the gaseous signaling molecule involved in the regulation of numerous vital biological functions, contributes to the development and progression of multiple age- and lifestyle-related diseases. While l-arginine is the precursor for the synthesis of NO by endothelial-nitric oxide synthase (eNOS), oral l-arginine supplementation is largely ineffective at increasing NO synthesis and/or bioavailability for a variety of reasons. l-citrulline, found in high concentrations in watermelon, is a neutral alpha-amino acid formed by enzymes in the mitochondria that also serves as a substrate for recycling l-arginine. Unlike l-arginine, l-citrulline is not quantitatively extracted from the gastrointestinal tract (i.e., enterocytes) or liver and its supplementation is therefore more effective at increasing l-arginine levels and NO synthesis. Supplementation with l-citrulline has shown promise as a blood pressure lowering intervention (both resting and stress-induced) in adults with pre-/hypertension, with pre-clinical (animal) evidence for atherogenic-endothelial protection. Preliminary evidence is also available for l-citrulline-induced benefits to muscle and metabolic health (via vascular and non-vascular pathways) in susceptible/older populations. In this review, we examine the impact of supplementing this important urea cycle intermediate on cardiovascular and metabolic health outcomes and identify future directions for investigating its therapeutic impact on cardiometabolic health.

pdf over here

http://www.mdpi.com/2072-6643/10/7/921

This is something Malcolm Kendrick has mentioned along with l-arginine, I might try it when my next supplement order is due. Theoretically I am generating loads of NO from the sunshine. Will be interesting to see if the weather affects future CVD rates.

l-Citrulline is cheaper at least in the USA and works better than arginine for NO. There are other natural products that also work on nitric oxide. For people who may needed it like diabetic that suffer more damage it may be wise to supplement with some of this natural products that with diet alone you will not achieve in therapeutic levels. They may heal and prevent more damage.

Yes I tried l-arginine but not yet l-citrulline

Why does some of this stuff have hydrogenated vegetable oil in it? D.

They don't want you getting too healthy or you might stop buying it.