Oh Dear, More Science

http://www.australiannationalreview.com/world-renown-heart-surgeon-speaks-heart-disease/

How High Carbohydrate Foods Can Raise Risk For Heart Problems

https://www.sciencedaily.com/releases/2009/06/090625133215.htm

New Perspectives on Atherogenesis
Role of Abnormal Triglyceride-Rich Lipoprotein Metabolism

http://circ.ahajournals.org/content/106/16/2137

(I didn't read that one yet)

From 1957

http://sci-hub.io/10.1001/jama.1957.02980290001001

From 1958

http://hopefulgeranium.blogspot.co.uk/2013/11/dr-richard-mackarness-meets-low-carb.html

And more

http://www.ncl.ac.uk/press/news/2017/06/fattyliverdiseasereversed/

low carb does this, David Unwin has a paper on the subject AFAICR

Is dietary carbohydrate essential for human nutrition?

http://ajcn.nutrition.org/content/75/5/951.2.long

the answer is no, obviously

A nice chunk of history, by Gerald Reaven and for once not paywalled

http://www.cell.com/cell-metabolism/fulltext/S1550-4131(04)00007-5

More history

http://vernerwheelock.com/264-the-wisdom-of-petr-skrabenek/

Fructose vs. insulin resistance

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC552336/

More on Omega 6 and other fats, from 1998

http://www.jci.org/articles/view/119546/version/1/pdf/render

More on "heart healthy" seed oils

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642429/

Stephan Guyenet came up with some interesting stuff on his old blog Whole Heath Source, including a theory that perhaps these oils were originally toxic (as per the Rose Corn Oil Trial) but after their consumption increased massively it actually became better to add more of them than to add saturated fat - unless of course you cut them back drastically.

The he had his brain removed so he could work for Michael Schwartz on his "Food Reward" theory that no-one else understood, and fight with Gary Taubes by claiming insulin actually made you thin. Now he's gone back to looking at the negative effects of Omega 6 again, something a whole bunch of others are now also studying (and not before time)

Up to date stuff looking at glucagon with Roger Unger

https://academic.oup.com/endo/article/2965091

2009 and finally the ADA get around to looking at 1 hour postprandials in "prediabetes"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628694/

Jim Johnson looks at insulin and obesity

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628694/

and even more up to date

http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30862-8

(Gareth Lim now also has his own lab while Jim is in Oxford, currently employed by Novo Nordisk but still pursuing science rather than dogma)

Phew!

Phew! indeed    more reading matter to take in 

Meanwhile 

Fasting Plasma Glucose and HbA1c Associated With an Increased Risk of Alzheimer Disease: 

http://care.diabetesjournals.org/content/early/2017/07/10/dc16-2238

A WTF moment

Type 2 diabetes: Value of home blood sugar monitoring unclear

In a study published in JAMA Internal Medicine, researchers enrolled 450 people with Type 2 diabetes, none of whom were taking insulin. They were randomly assigned to one of three groups:

• no self-monitoring of blood sugar
  
• once daily self-monitoring of blood sugar
  
• once-daily self-monitoring of blood sugar with “enhanced feedback” from their blood glucose meters with messages intended to educate and motivate the study volunteers.
  

After one year these researchers found that, compared with those not self-monitoring blood sugar, those who self-monitored had no improvement in the control of their blood sugar, and had no improvement in measures of quality of life.

http://www.health.harvard.edu/blog/type-2-diabetes-value-home-blood-sugar-monitoring-unclear-2017072411989

Looks like I'm a member of a cult 

Statin Denialism Is 'A Deadly Internet-Driven Cult'

https://www.medpagetoday.com/cardiology/cardiobrief/66863

Efficacy of low carbohydrate diet for type 2 diabetes mellitus management: A systematic review and meta-analysis of randomized controlled trials

http://www.diabetesresearchclinicalpractice.com/article/S0168-8227(17)30402-3/fulltext

Alas the last link is paywalled only the abstract is available

OK I'll play

https://academic.oup.com/edrv/article/doi/10.1210/er.2017-00111/3892397/Obesity-Pathogenesis-An-Endocrine-Society

Michael Schwartz, I haven't dragged myself to reading it yet, it's a bit long but I predict insulin and carbs won't be mentioned much if at all

Rory Robertson tries to get through the thick skulls of the Australian Government

http://www.australianparadox.com/pdf/Expanded-Letter-HealthDept-type2diabetes.pdf

Meanwhile this is a big surprise

http://www.pulsetoday.co.uk/clinical/more-clinical-areas/diabetes/why-gps-should-prescribe-a-low-carb-diet-for-type-2-diabetes/20034873.article`

especially the numerous favourable replies, hopefully this will be read by many more doctors.

chris c wrote:OK I'll play

https://academic.oup.com/edrv/article/doi/10.1210/er.2017-00111/3892397/Obesity-Pathogenesis-An-Endocrine-Society

Michael Schwartz, I haven't dragged myself to reading it yet, it's a bit long but I predict insulin and carbs won't be mentioned much if at all

Rory Robertson tries to get through the thick skulls of the Australian Government

http://www.australianparadox.com/pdf/Expanded-Letter-HealthDept-type2diabetes.pdf

Meanwhile this is a big surprise

http://www.pulsetoday.co.uk/clinical/more-clinical-areas/diabetes/why-gps-should-prescribe-a-low-carb-diet-for-type-2-diabetes/20034873.article`

especially the numerous favourable replies, hopefully this will be read by many more doctors.

Excellent from Pulse I put the article on the blog on Friday, there does appear a gathering of momentum for LC amongst GP's no doubt the publicity generated by Dr Unwin has had some influence and of course it's hard to ignore a diet than has so many benefits for diabetics

I suspect possibly less pressure from the likes of PCTs as their replacement CCGs appear to have more input from doctors and less from accountants. Certainly our local surgery seems an order of magnitude more relaxed without everyone looking over their shoulders for Big Brother to get them.

Yes it gets harder to dismiss successful patients as "just anecdotes" when there are so many of them, and (hopefully) more doctors are accessing the internet.

Now Ethics Committees are less likely to block low carb studies and even the most prestigious journals are finally publishing them, I think there's at least some pressure coming from above as well as the pressure from below. Already DUK has partly backed down. Dieticians, not so much, obviously.

chris c wrote:I suspect possibly less pressure from the likes of PCTs as their replacement CCGs appear to have more input from doctors and less from accountants. Certainly our local surgery seems an order of magnitude more relaxed without everyone looking over their shoulders for Big Brother to get them.

Yes it gets harder to dismiss successful patients as "just anecdotes" when there are so many of them, and (hopefully) more doctors are accessing the internet.

Now Ethics Committees are less likely to block low carb studies and even the most prestigious journals are finally publishing them, I think there's at least some pressure coming from above as well as the pressure from below. Already DUK has partly backed down. Dieticians, not so much, obviously.

Dietitians like these 

https://twitter.com/KelloggsRDs

You Just Couldn't Make This Up!

Interesting thoughts from Gary Fettke. The Militant Vegans and Militant Statinists and Cholesterol supporters all have a seemingly religious fervour. Now it looks like it actually IS religious fervour

http://foodmed.net/2017/08/07/medical-evangelism-adventist-diet-advice/

I knew the Kelloggs connection - breakfast cereal was originally invented to prevent masturbation (which works when you eat it for long enough due to diabetic neuropathy and arterial damage) but had no clue about the Vegan connection and the huge influence of the Seventh Day Adventists beyond knowing they were largely but not exclusively vegetarian and starred in numerous studies.

Meanwhile some more reality

Retrospective study on the efficacy of a low-carbohydrate diet for impaired glucose tolerance

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063858/

Long-term effects of a ketogenic diet in obese patients

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/

and an oldie

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811436/

more modern research throws some further light on this, Richard Feinman et al have showed that carbs increase Free Fatty Acids in the blood through inhibiting their metabolism until after all the carbs have been dealt with - which never happens when you are eating your dietician-approved three carby meals and three carby snacks per day

Oops!

https://www.karger.com/Article/Abstract/477216

Bradford Hill wouldn't be totally impressed, but quite a difference in HR between LDL vs. trigs/HDL, ie.
insulin resistance

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625988/pdf/permj19_4p0004.pdf

Yes you could "open a new therapeutic
window on reducing elevated levels of triglyceride rich
lipoproteins through activation of lipoprotein
lipase

or you could just eat fewer carbs

More on IR which makes it look like lipids are more of a marker and less of a cause, from 13 years ago

http://www.jlr.org/content/45/3/507.long

Yet more pathways between glucose, insulin and CVD, from 11 years ago

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550220/

and from nine years ago

http://journals.lww.com/cardiovascularpharm/Fulltext/2008/10000/High_Glucose_Concentration_Increases_Macrophage.5.aspx

Selenium and Co-Q10 totally blow statins out of the water

http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0141641&type=printable

Enough for now, time to go listen to London Grammar, goodnight!

http://www.nejm.org.sci-hub.bz/doi/full/10.1056/NEJMe1706907?query=TOC

It's pointless trying to discuss low carb with a low-fat fanatic. Most of them refuse to discuss the science, and merely try to shout-down the low carber. Just like global warming fanatics when faced with a 'denier' (Their word, not mine!)

Wobblycogs wrote:It's pointless trying to discuss low carb with a low-fat fanatic. Most of them refuse to discuss the science, and merely try to shout-down the low carber. Just like global warming fanatics when faced with a 'denier' (Their word, not mine!)

"It's pointless trying to discuss low carb with a low-fat fanatic" Agreed, but winding 'em up is one hell of a hoot, just ask Graham.

Eddie wrote:

Wobblycogs wrote:It's pointless trying to discuss low carb with a low-fat fanatic. Most of them refuse to discuss the science, and merely try to shout-down the low carber. Just like global warming fanatics when faced with a 'denier' (Their word, not mine!)

"It's pointless trying to discuss low carb with a low-fat fanatic" Agreed, but winding 'em up is one hell of a hoot, just ask Graham.

And winding them up is so easy it does help when they have zero sense of humour   and the very fact were still here despite their warnings of the dire consequences of LCHF must be hard for them to take 

I did try being nice to them but the cherub took exception to me calling her sweetie   obviously my gesture in an attempt to resolve our differences was spurned out of hand 

Interesting study on chocolate 

Brachial and Cerebrovascular Functions Are Enhanced in Postmenopausal Women after Ingestion of Chocolate with a High Concentration of Cocoa

http://jn.nutrition.org/content/early/2017/08/08/jn.117.250225.abstract

Thanks Graham.

But of course cocoa powder isn't harmful. It's the milk and sugar they mix with it that make chocolate 'sinful'! Try double cream, whipped to firmness and sprinkled with cocoa. Not a grain of sugar in sight! Quite palatable if you don't over do the cocoa!  

Cheers Wobbly John

Of course fasting can be harmful.

If you don't eat you will die!  

Wouldn't the human body be designed to survive emergency fasts? Our ancestors must have been hungry quite frequently. when food supplies dwindled and became scarce.  Nowadays of course we are smart enough to make our own food; and stupid enough to eat it!

Seriously I think many people regard fasting as going without food for a week or more. I couldn't go that long with just water. However, I don't eat very much at all on Mondays. Just water and a couple of servings of my home-made consommés. Give the system the weekly rest it deserves. Tonight I am going to have a 'full English' tea... With mushrooms!

Cheers  Wobbly John  

For many folks these days, fasting lasts about half and hour, then it's munching junk until the next err...junk meal. I heard of a bloke that could get by on 17 grams of cornflakes and a splash of semi-skimmed. Last I heard he ended up in the Rubber Ramada, completely batshit. Lack of healthy fats evidently, a sobering lesson for us all.

graham64 wrote:

Eddie wrote:

Wobblycogs wrote:It's pointless trying to discuss low carb with a low-fat fanatic. Most of them refuse to discuss the science, and merely try to shout-down the low carber. Just like global warming fanatics when faced with a 'denier' (Their word, not mine!)

"It's pointless trying to discuss low carb with a low-fat fanatic" Agreed, but winding 'em up is one hell of a hoot, just ask Graham.

And winding them up is so easy it does help when they have zero sense of humour   and the very fact were still here despite their warnings of the dire consequences of LCHF must be hard for them to take 

I did try being nice to them but the cherub took exception to me calling her sweetie   obviously my gesture in an attempt to resolve our differences was spurned out of hand 

https://theoverheardpress.com/2017/02/10/low-fat-diet-harms-part-of-brain-responsible-for-hearing-criticism-of-low-fat-diet/

Meanwhile this is astonishing

http://letthemeatmeat.com/tagged/Seventhday_Adventists

and of course

http://www.pmlive.com/pharma_news/type_2_diabetes_market_set_to_soar,_says_globaldata_1202514

Buy shares now and invest the profits into grassfed meat and veggies