Microbes and Alzheimer’s Disease

Microbes and Alzheimer’s Disease

http://content.iospress.com/articles/journal-of-alzheimers-disease/jad160152

In summary, we propose that infectious agents, including HSV1, Chlamydia pneumonia, and spirochetes, reach the CNS and remain there in latent form. These agents can undergo reactivation in the brain during aging, as the immune system declines, and during different types of stress (which similarly reactivate HSV1 in the periphery). The consequent neuronal damage— caused by direct viral action and by virus-induced inflammation— occurs recurrently, leading to (or acting as a cofactor for) progressive synaptic dysfunction, neuronal loss, and ultimately AD. Such damage includes the induction of Aβ which, initially, appears to be only a defense mechanism.

AD causes great emotional and physical harm to sufferers and their carers, as well as having enormously damaging economic consequences. Given the failure of the 413 trials of other types of therapy for AD carried out in the period 2002–2012 [79], antiviral/antimicrobial treatment of AD patients, notably those who are APOE ɛ4 carriers, could rectify the ‘no drug works’ impasse. We propose that further research on the role of infectious agents in AD causation, including prospective trials of antimicrobial therapy, is now justified.

"AD causes great emotional and physical harm to sufferers and their carers, as well as having enormously damaging economic consequences. Given the failure of the 413 trials of other types of therapy for AD carried out in the period 2002–2012 [79], antiviral/antimicrobial treatment of AD patients, notably those who are APOE ɛ4 carriers, could rectify the ‘no drug works’ impasse. We propose that further research on the role of infectious agents in AD causation, including prospective trials of antimicrobial therapy, is now justified."

Alzheimer's is such a cruel disease - you lose your loved ones long before they pass away.
Research is needed, perhaps more than ever now with an ever increasing older generation.

Thanks for posting this Yoly

All the best Jan

Thanks Jan;

Hope they are wrong and nutrition and lifestyle can have a bigger impact on risk. Anti-virals aren't easy and they have a lot of side effect. If is a virus it will spoil most attempt at prevention.

Hi Yoly
There is so much still to know about Alzheimer's.
From my own point of view, having Alzheimer's in the family is one of the reasons I now live the LCHF lifestyle. Will it help? Will it keep Alzheimer's at bay? Time and health will tell.

All I can definitely say is that since Eddie's diagnosis with Type 2 Diabetes and we now both embrace the LCHF lifestyle, my health and well being has been good, and of course Eddie's blood sugars are that of a non diabetic and stable.

Thanks for all the papers you find and post here ...

All the best Jan

Yes great stuff as always Yoly!

This is a theory I hadn't come across before, unlike for example a potential link between various infections and CVD, especially dental infections. Maybe the link is with the various inflammatory cytokines, which of course are a vital part of the body's defence mechanism against infection.

chris c wrote:Yes great stuff as always Yoly!

This is a theory I hadn't come across before, unlike for example a potential link between various infections and CVD, especially dental infections. Maybe the link is with the various inflammatory cytokines, which of course are a vital part of the body's defence mechanism against infection.

Gut biome and Parkinsons has been linked recently.

Also high liver enzymes...but having a probiotic for two+months made no difference to my GGT.
Derek