High TG, low HDL-C levels may help further stratify CHD risk

(HealthDay)—A high fasting triglyceride (TG) level combined with a low high-density lipoprotein cholesterol (HDL-C) level is associated with increased risks of incident coronary heart disease (CHD) and ischemic stroke, especially for patients with diabetes or a low-density lipoprotein cholesterol (LDL-C) level of ≥130 mg/dL, independent of other atherosclerotic cardiovascular disease risk factors, according to a study published online Jan. 25 in Diabetes Care.

Jennifer S. Lee, M.D., from the Stanford University Medical Center in California, and colleagues studied 3,216 American Indians (41 percent with diabetes) who were free from cardiovascular disease at baseline in a prospective cohort (median follow-up 17.7 years). The authors estimated hazard ratios (HRs) for incident ischemic stroke and coronary heart disease in relation to combined TG and HDL-C status (fasting TG level ≥150 mg/dL was high; fasting HDL-C level <40 mg/dL [for men] was low).

The researchers found that, compared to those with normal TG and HDL levels, participants with high TG and low HDL levels had a 1.32-fold elevated HR for CHD. In participants with, but not those without, diabetes, high TG plus low HDL levels correlated with a 1.54- and 2.13-fold increased HR for CHD and stroke, respectively (P value for interaction = 0.003 and 0.060, respectively). In participants with LDL-C levels of ≥130 mg/dL, high TG and low HDL correlated with CHD risk; this was not seen in participants with lower LDL-C levels. The correlations were not modified by sex.

"Adults with both high TG and low HDL-C, particularly those with diabetes, have increased risks of incident CHD and stroke," the authors write. "Recognition of these patterns may help to enhance lipid-targeted strategies to prevent CHD and ischemic stroke."

https://medicalxpress.com/news/2017-02-high-tg-hdl-c-stratify-chd.html

I reckon lipid-targeted strategies wont include the best and safest way to lower trigs and raise HDL levels and that's LCHF

Problem is Graham we are very fragile creatures and whatever we do is no copper bottomed guarantee! Derek

Derek wrote:Problem is Graham we are very fragile creatures and whatever we do is no copper bottomed guarantee! Derek

No guarantees in life Derek, who knows what lies in store could be run over by a bus tomorrow 

Trigs/HDL ratio relates to insulin resistance which is frankly more likely to be causal. Yes high trigs (such as I had most of my life) can be seen as an indicator of excess carbs, especially fructose, and low HDL (such as I also had most of my life) can be seen as an indicator of insufficient fat, particularly saturated fat. Of course along with healthy animal fat comes a load of nutrients not found in "vegetable" oils, and not found in all the carbs either.

graham64 wrote:

No guarantees in life Derek, who knows what lies in store could be run over by a bus tomorrow 

Won't be a British bus though. Well not round here, they're all Scanias. Are Dennis still in business?

chris c wrote:

graham64 wrote:

No guarantees in life Derek, who knows what lies in store could be run over by a bus tomorrow 

Won't be a British bus though. Well not round here, they're all Scanias. Are Dennis still in business?

Yep Dennis are still in business, when Leyland bus closed a few engineers ended up working for them

Good to hear! I knew their erstwhile MD, John Smith. A truly worthwhile businessman with a keen eye for niche markets, like midibuses, and the Alleycat dustcart which was small and especially narrow for city streets. In fact the exact opposite of Donald Stokes. Well he was full of rubbish too I suppose.

chris c wrote:Good to hear! I knew their erstwhile MD, John Smith. A truly worthwhile businessman with a keen eye for niche markets, like midibuses, and the Alleycat dustcart which was small and especially narrow for city streets. In fact the exact opposite of Donald Stokes. Well he was full of rubbish too I suppose.

I would think stagecoach use Dennis because Brian Souter is a major shareholder in them he and his sister own 55% of the shares in Dennis

In my day they were owned by Hestair. Then they were bought out AFAICR by their own management group Trinity Holdings. Fascinating history, the Dennis Brothers started out by assembling bicycles using an apple tree in their garden as a jig. They also made big lawnmowers that lasted forever, some may still be going. They did make mainstream trucks for a while but rather than compete with other manufacturers they concentrated on municipal vehicles, we still have their dustcarts here, the big buggers. Their only failure that I can recall was their roadsweeper which just wasn't very good and had been known to burst into flames due to the encapsulated Volvo engine.

Allegedly there was a "gentleman's agreement" that anyone enquiring about the Dennis sweeper was politely guided towards Johnstons in the next town, and conversely anyone enquiring about Johnston's dustcart which was also rather mediocre was referred to Dennis.

graham64 wrote:

Derek wrote:Problem is Graham we are very fragile creatures and whatever we do is no copper bottomed guarantee! Derek

No guarantees in life Derek, who knows what lies in store could be run over by a bus tomorrow 

My problem Graham is that I've had undiagnosed Conn's for thirty years and my ticker is not what it was due the nature of excess aldosterone damaging all tissue with receptors. Found out all this stuff a bit too late in the day!
Still, I have stopped reactive hypoglycemia with low carb. D.

Yeah I accept that I'm going to be dead soon whatever I do, but I try to make up for the lost time of feeling like crap as I slowly disintegrated while being assured I was making up all my symptoms and doctors concentrated on finding psychiatric reasons for my doing this rather than looking at my BG, and they still haven't and won't look at my insulin levels. There's a LOT of it about, and it will continue as long as they are only interested in "cholesterol".

graham64 wrote:
Yep Dennis are still in business, when Leyland bus closed a few engineers ended up working for them

Now that IS interesting! Plaxtons I know from the Panorama often fitted to Bristols, and other chassis, and Alexanders from the Atlanteans, Reliances etc. The Leyland guys must have brought the names with them - Leopard, Panther etc. now Plaxtons coaches.

http://www.dennissociety.org.uk/history.html

Not much left in Guildford though.

http://www.jdcfire.co.uk

As a fellow old fart you may like this site I've been reading through

http://www.old-bus-photos.co.uk/

chris c wrote:

graham64 wrote:
Yep Dennis are still in business, when Leyland bus closed a few engineers ended up working for them

Now that IS interesting! Plaxtons I know from the Panorama often fitted to Bristols, and other chassis, and Alexanders from the Atlanteans, Reliances etc. The Leyland guys must have brought the names with them - Leopard, Panther etc. now Plaxtons coaches.

http://www.dennissociety.org.uk/history.html

Not much left in Guildford though.

http://www.jdcfire.co.uk

As a fellow old fart you may like this site I've been reading through

http://www.old-bus-photos.co.uk/

OK i'll admit to being an old fart but but those photos were definitely before my time   interestingly there is a bus I never knew existed namely the Leyland Titanic   

http://www.old-bus-photos.co.uk/?tag=leyland-titanic

I'm surprised Stokes didn't bring the name back! Would have been very fitting.

There were still quite a lot of old buses around in my day, some of them lasted a couple of decades in use - where I was born and brought up was London Country/Greenline territory so we only had AEC RTs and RFs until Fleetlines appeared. Everywhere else I ever lived was Tilling land so mostly Bristols, but I can remember Guy Arabs, Leyland Titans etc. from other places like holiday destinations. Oh and Bedford coaches with Duple bodies from school trips. I can even recall the sound of a petrol Bedford OB! And in those days high trigs were maths, one of my least favourite subjects.

chris c wrote:I'm surprised Stokes didn't bring the name back! Would have been very fitting.

There were still quite a lot of old buses around in my day, some of them lasted a couple of decades in use - where I was born and brought up was London Country/Greenline territory so we only had AEC RTs and RFs until Fleetlines appeared. Everywhere else I ever lived was Tilling land so mostly Bristols, but I can remember Guy Arabs, Leyland Titans etc. from other places like holiday destinations. Oh and Bedford coaches with Duple bodies from school trips. I can even recall the sound of a petrol Bedford OB! And in those days high trigs were maths, one of my least favourite subjects.

Can any of you remember the slatted seat double deckers they had in the war? They were a hard ride! D.

That was a bit before my time though I expect they were still around into the sixties in some places - Utility specification. There are some reminiscences about them on that website. I'm now trying to remember if some of the open-top seaside buses had wooden seats.

Derek wrote:

chris c wrote:I'm surprised Stokes didn't bring the name back! Would have been very fitting.

There were still quite a lot of old buses around in my day, some of them lasted a couple of decades in use - where I was born and brought up was London Country/Greenline territory so we only had AEC RTs and RFs until Fleetlines appeared. Everywhere else I ever lived was Tilling land so mostly Bristols, but I can remember Guy Arabs, Leyland Titans etc. from other places like holiday destinations. Oh and Bedford coaches with Duple bodies from school trips. I can even recall the sound of a petrol Bedford OB! And in those days high trigs were maths, one of my least favourite subjects.

Can any of you remember the slatted seat double deckers they had in the war?  They were a hard ride! D.

I was a war baby so probably before my time too Derek

Mostly I seem to remember patterned moquette, like the trains, some of which was woven from horsehair, and later vinyl. Luxury!

graham64 wrote:

Derek wrote:

chris c wrote:I'm surprised Stokes didn't bring the name back! Would have been very fitting.

There were still quite a lot of old buses around in my day, some of them lasted a couple of decades in use - where I was born and brought up was London Country/Greenline territory so we only had AEC RTs and RFs until Fleetlines appeared. Everywhere else I ever lived was Tilling land so mostly Bristols, but I can remember Guy Arabs, Leyland Titans etc. from other places like holiday destinations. Oh and Bedford coaches with Duple bodies from school trips. I can even recall the sound of a petrol Bedford OB! And in those days high trigs were maths, one of my least favourite subjects.

Can any of you remember the slatted seat double deckers they had in the war?  They were a hard ride! D.

I was a war baby so probably before my time too Derek

I was born a few months before the war and can still feel those seats on the bumpy roads!

Derek wrote:I was born a few months before the war and can still feel those seats on the bumpy roads!

Post war bus seats were not really comfortable for longer journeys but must have been far better than the wooden ones, I did have a 250 BSA with a rigid rear suspension in the 60s so I did feel the bumps on that 

I have a friend named Vince who was named after the motorbike. Now there was some advanced technology for its time.

chris c wrote:I have a friend named Vince who was named after the motorbike. Now there was some advanced technology for its time.

Had a few bikes myself. 500 twin solid back end triumph, James 197 that I knackered the big end and mains and took to pieces on the kitchen table when mother was out and got a bollocking when she came back cos of the mess. Had a 125 bantam but nearly had a nasty end when I wrote off my 650 matchless when I hit a gypsy lorry near Kettering. Happy days. The Vincent engines were better put in the Norton feather bed frame, you couldn't get the Vincents down far enough to go round bends fast. Would have loved one but doubt I would be here to day if I had! D.

Vince had an unfinished project (he only collected half the parts) to put a Hillman Imp engine into a Featherbed frame.

Old joke

"Do you suffer from black oily stools?"

"Only when I mend my motorbike in the kitchen"

My father in law was a biker and amongst others he owned a vincent he did say it was a bit of a beast when cornering at high speeds.

Yes a bit like the Leyland National, very good at going in a straight line, especially if you didn't want it to.