Metabolic memory of ß-cells controls insulin secretion and is mediated by CaMKIIa

Abstract

Ca2+/calmodulin-dependent protein kinase II (CaMKII) functions both in regulation of insulin secretion and neurotransmitter release through common downstream mediators. Therefore, we hypothesized that pancreatic ß-cells acquire and store the information contained in calcium pulses as a form of “metabolic memory”, just as neurons store cognitive information. To test this hypothesis, we developed a novel paradigm of pulsed exposure of ß-cells to intervals of high glucose, followed by a 24-h consolidation period to eliminate any acute metabolic effects. Strikingly, ß-cells exposed to this high-glucose pulse paradigm exhibited significantly stronger insulin secretion. This metabolic memory was entirely dependent on CaMKII. Metabolic memory was reflected on the protein level by increased expression of proteins involved in glucose sensing and Ca2+-dependent vesicle secretion, and by elevated levels of the key ß-cell transcription factor MAFA. In summary, like neurons, human and mouse ß-cells are able to acquire and retrieve information.

Complete study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060215/

That is probably why when you do high carb it takes time for the pancreas to adjust when you change your diet. It also in part explain why when you do low carb you need some days to adjust before a blood glucose challenge test. I wonder if there is also a set point for blood glucose level in memory some place for what is normal blood glucose level. Were the body is set to run higher in some people.

Good points! I was scratching my head wondering why.