Serum magnesium is inversely associated with coronary artery calcification

Serum magnesium is inversely associated with coronary artery calcification in the Genetics of Atherosclerotic Disease (GEA) study

Abstract

Background
Serum magnesium is inversely associated to coronary artery calcification (CAC) in patients with chronic kidney disease. There is little information on this association in a general healthy population.

Objective
The aim of this study was to examine the cross-sectional association of serum magnesium levels with CAC.

Methods
We included 1276 Mexican-mestizo subjects (50 % women), aged 30–75 years, free of symptomatic cardiovascular disease. CAC was quantified by multidetector computed tomography using the method described by Agatston. Cross-sectional associations of serum magnesium with cardiometabolic factors and subclinical atherosclerosis defined as a CAC score > 0, were examined in logistic regression models adjusted for age, sex, education, smoking status, body mass index, systolic blood pressure, physical activity, elevated abdominal visceral tissue, fasting insulin and glucose, alcohol consumption, menopausal status (women only), low (LDL-C) and high density lipoprotein cholesterol (HDL-C), triglycerides, diuretic use, type 2 diabetes mellitus (DM2), and family history of DM2.

Results
After full adjustment, subjects in the highest quartile of serum magnesium had 48 % lower odds of hypertension (p = 0.028), 69 % lower odds of DM2 (p = 0.003), and 42 % lower odds of CAC score > 0 (p = 0.016) compared to those with the lowest serum magnesium. The analyses also showed that a 0.17 mg/dL (1SD) increment in serum magnesium was independently associated with 16 % lower CAC (OR 0.84, 95 % CI 0.724–0.986).

Conclusions
In a sample of Mexican-mestizo subjects, low serum magnesium was independently associated to higher prevalence not only of hypertension and DM2, but also to coronary artery calcification, which is a marker of atherosclerosis and a predictor of cardiovascular morbidity and mortality.

Full study here:  http://nutritionj.biomedcentral.com/articles/10.1186/s12937-016-0143-3

Thanks for reminding me, I was going to order some more magnesium, but then I got stuck on what else, D3, probably I'll try krill oil rather than fish oil, K2 and Co-Q10 in an attempt to delete some of my plaque.

Long ago Katharine Morrison turned me on to an excellent supplier, but they have now been taken over and have started spamming me which their predecessors never did. Vitality Vitamins, anyone ever used them?

Problem with Krill oil it is not a sustainable fishery and will result in reduction in Whales and Penguins eventually.

chris c wrote:Thanks for reminding me, I was going to order some more magnesium, but then I got stuck on what else, D3, probably I'll try krill oil rather than fish oil, K2 and Co-Q10 in an attempt to delete some of my plaque.

Long ago Katharine Morrison turned me on to an excellent supplier, but they have now been taken over and have started spamming me which their predecessors never did. Vitality Vitamins, anyone ever used them?

Never heard of Vitality Vitamins Chris, just had a google and can't find many reviews of the company, I found a site with good reviews that seems OK but that's just my opinion as I've never used them 

http://www.naturesbest.co.uk/krill-oil-p520/

Derek wrote:Problem with Krill oil it is not a sustainable fishery and will result in reduction in Whales and Penguins eventually.

Not sure I entirely buy that, considering the vast volumes of the things.