Paleo diet is dangerous, increases weight gain, diabetes expert warns

chris c wrote:Obviously the lack of fat has affected his brain. Mice eat carbs. People eat fat. When the opposite happens, things go wrong.

chris c wrote:Obviously the lack of fat has affected his brain. Mice eat carbs. People eat fat. When the opposite happens, things go wrong.

• The mouse strain in question was explicitly chosen because it is genetically predisposed to be fat and diabetic.  That is, that particular mouse is a polygenic model for obesity; it is bred and maintained for the purpose of studying getting fat.
  

• This strain of mouse genetically develops diabetes from about 20 weeks of age on its own.  You don't have to cause it with diet and suppression of insulin activity, it's part of the mouse's genetic make-up!
  

• Complete elimination of carbohydrate, even in these mice, prevented diabetes.  Oh, you didn't read that in the news article, did you?  Well, here it is:
  

• The low-carb "diet" fed to the mice (6% carb) was deliberately tampered with in a fashion that would never happen in human subjects; specifically: "The carbohydrate content of the LCHFD was exclusively derived from simple sugar (sucrose: 106 g kg−1)"  Notably, a normal rodent diet contains only 2% simple sugars!  In other words the study diet had three times the fast-carbohydrate glycemic load of normal rodent chow.
  

• The low-carb "diet" had 45% of its fat from unsaturated sources.  This is NOT what anyone I know who eats this way does.  Specifically, on a mass-basis (1,000 parts total) the fats were 400 parts cocoa butter, 100 parts canola oil and 100 parts clarified butter fat (ghee.) While cocoa butter doesn't scare me in small doses, making it the largest part of the intake -- 40% of the total consumed mass of food -- is insanely unbalanced.  Of the total only 1/6th of intake by mass was from animal sources; this again is not what people who eat this way do.  What's far worse is the inclusion of any amount of canola oil; that's specifically on the "do not eat" list when it comes to anyone attempting to do HFLC or Paleo for multiple reasons, not the least of which is its extraordinarily bad Omega 3:6 ratio.  By mass canola oil was a full 10% of the chow!
  

See more: https://market-ticker.org/akcs-www?post=231141 

BACKGROUND/OBJECTIVES:
The contemporary American diet figures centrally in the pathogenesis of numerous chronic diseases--'diseases of civilization'--such as obesity and diabetes. We investigated in type 2 diabetes whether a diet similar to that consumed by our pre-agricultural hunter-gatherer ancestors ('Paleolithic' type diet) confers health benefits.

SUBJECTS/METHODS:
We performed an outpatient, metabolically controlled diet study in type 2 diabetes patients. We compared the findings in 14 participants consuming a Paleo diet comprising lean meat, fruits, vegetables and nuts, and excluding added salt, and non-Paleolithic-type foods comprising cereal grains, dairy or legumes, with 10 participants on a diet based on recommendations by the American Diabetes Association (ADA) containing moderate salt intake, low-fat dairy, whole grains and legumes. There were three ramp-up diets for 7 days, then 14 days of the test diet. Outcomes included the following: mean arterial blood pressure; 24-h urine electrolytes; hemoglobin A1c and fructosamine levels; insulin resistance by euglycemic hyperinsulinemic clamp and lipid levels.

RESULTS:
Both groups had improvements in metabolic measures, but the Paleo diet group had greater benefits on glucose control and lipid profiles. Also, on the Paleo diet, the most insulin-resistant subjects had a significant improvement in insulin sensitivity (r = 0.40, P = 0.02), but no such effect was seen in the most insulin-resistant subjects on the ADA diet (r = 0.39, P = 0.3).

CONCLUSIONS:
Even short-term consumption of a Paleolithic-type diet improved glucose control and lipid profiles in people with type 2 diabetes compared with a conventional diet containing moderate salt intake, low-fat dairy, whole grains and legumes.

http://www.ncbi.nlm.nih.gov/pubmed/25828624

yoly wrote:

chris c wrote:Obviously the lack of fat has affected his brain. Mice eat carbs. People eat fat. When the opposite happens, things go wrong.

What a novel concept different animals species have different dietary requirements. What a difficult concept for a dietician and medical personnel to understand.

graham64 wrote:No mice involved in this study    

<snip>

http://www.ncbi.nlm.nih.gov/pubmed/25828624

chris c wrote:

graham64 wrote:No mice involved in this study    

<snip>

http://www.ncbi.nlm.nih.gov/pubmed/25828624

Free pdf available! 

Looks like Linda Frasetto has followed up some of Staffan Lindeberg's studies here and come to highly similar conclusions. So no surprise there then.

Professor Andrikopoulos wrote: We are told to eat zero carbs and lots of fat on the Paleo diet

https://pursuit.unimelb.edu.au/articles/paleo-diets-weight-gain

Bill wrote:chris ...Low carb is being oked by CSIRO diet trial, it was a A$1.3 million expensive exercise. I could have told them for nothing
https://www.google.com.au/#q=csiro+diabetes&tbm=nws