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THE LOW CARB DIABETIC

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    New genetic form of obesity and diabetes discovered

    graham64
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    New genetic form of obesity and diabetes discovered Empty New genetic form of obesity and diabetes discovered

    Post by graham64 on Wed Jul 01 2015, 22:40

    Scientists have discovered a new inherited form of obesity and type 2 diabetes in humans.

    A large number of genes are involved in regulating body weight, and there are now over 30 genes known in which people with harmful changes in DNA sequence become extremely overweight. Similarly, there are a number of genes that can, when altered, cause type 2 diabetes. These conditions are inherited through families in exactly the same way as disorders such as cystic fibrosis or Huntington’s disease.

    It is unclear what proportion of severe obesity and type 2 diabetes is caused by genetic disease.

    Researchers at Imperial College London discovered the new defect by sequencing the DNA of an extremely obese young woman and members of her family. In addition to an increased appetite leading to severe weight problems from childhood, she had type 2 diabetes, learning difficulties, and reproductive problems.

    They found that she had inherited two copies of a harmful genetic change that meant she could not make a protein called carboxypeptidase-E (CPE). This is an enzyme that is important in the proper processing of a number of hormones and brain transmitters controlling appetite, insulin and other hormones important in the reproductive system.

    Studies have previously shown that CPE deficiency causes obesity, diabetes, and impaired memory in mice, but no humans with the condition have been found before. CPE deficiency is a recessive condition, so a person would need to inherit the altered genetic sequence from both parents to be affected.

    The study, published in the journal PLOS ONE, was funded by the NIHR Imperial Biomedical Research Centre and Diabetes UK.

    http://www3.imperial.ac.uk/

    OK it's only a study of the members of one family but another possible reason for obesity and diabetes other than it's down to lifestyle and we brought it on ourselves


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    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

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    Jan1
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    New genetic form of obesity and diabetes discovered Empty Re: New genetic form of obesity and diabetes discovered

    Post by Jan1 on Thu Jul 02 2015, 10:54

    Interesting to read Graham - as Professor Alex Blakemore from the Department of Medicine at Imperial College London, who led the study, said: “There are now an increasing number of single-gene causes of obesity and diabetes known. We don’t know how many more have yet to be discovered, or what proportion of the severely obese people in our population have these diseases - it is not possible to tell just by looking.

    “These are serious disorders that affect the body’s ability to regulate hunger and fullness signals. They are inherited in the just same way as other genetic diseases and the sufferers should not be stigmatised for their condition. They should be offered genetic counselling and specialised lifelong support to allow them as healthy a life as possible.”

    Talking as a non medical person hereditary genes surely plays a part in families. It could be diabetes, Alzheimer's, heart problems but we must still do what we can to improve our health and that has to be better eating / lifestyle choices.

    Don't know what others may think !

    All the best Jan

      Current date/time is Fri Jan 15 2021, 17:54