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    Statins for Primary Prevention

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    graham64
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    Statins for Primary Prevention

    Post by graham64 on Wed Jan 04 2017, 21:59

    The Debate Is Intense, but the Data Are Weak


    A recent issue of JAMA contains the latest US Preventive Services Task Force (USPSTF) recommendation statement on statins for prevention of cardiovascular disease in adults,1 along with the accompanying evidence report and systematic review2 on which the recommendations are based. The evidence report summarized data from 19 trials including a total of 71 344 patients and concluded that statin therapy was associated with reduced risk of all-cause and cardiovascular mortality and cardiovascular disease (CVD) events. Thus, the task force recommended “initiating use of low- to moderate-dose statins in adults aged 40 to 75 years without a history of CVD who have 1 or more CVD risk factors and a calculated 10-year CVD event risk of 10% or greater (B recommendation)” or “7.5% to 10% (C recommendation).”1 Although the task force did their usual careful job of reviewing the evidence, the evidence for treating asymptomatic persons with statins does not appear to merit a grade B or even a grade C recommendation.

    http://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2582853

    Full text behind paywall but the first page of the PDF can be viewed 


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    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

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    chris c
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    Re: Statins for Primary Prevention

    Post by chris c on Wed Jan 04 2017, 22:24

    I thought even the manufacturers didn't recommend them for over 70s? As Malcolm Kendrick pointed out from other studies, if you take them for years they *may* extend your life by a few days.
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    graham64
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    Re: Statins for Primary Prevention

    Post by graham64 on Thu Jan 05 2017, 22:40

    @chris c wrote:I thought even the manufacturers didn't recommend them for over 70s? As Malcolm Kendrick pointed out from other studies, if you take them for years they *may* extend your life by a few days.

    Yes but if they prevent Alzheimers Cool : The use of statins could be a cheap and relatively easy way to ward off Alzheimer's disease. A new study in The Journal of the American Medical ... http://kticradio.com/abc_health/your-body-use-of-statins-to-ward-off-alzheimers-risk-abcid35837793/


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    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over nine years,

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
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    Derek
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    Re: Statins for Primary Prevention

    Post by Derek on Fri Jan 06 2017, 14:19

    @chris c wrote:I thought even the manufacturers didn't recommend them for over 70s? As Malcolm Kendrick pointed out from other studies, if you take them for years they *may* extend your life by a few days.

    Malcolm Kendrick is a bit of a moveable feast, he now thinks heart disease is due to lack of sunshine and low vit D!

    He has hedged his bets somewhat on LDL as well!
    D.
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    Eddie
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    Re: Statins for Primary Prevention

    Post by Eddie on Fri Jan 06 2017, 15:10

    @Derek wrote:
    @chris c wrote:I thought even the manufacturers didn't recommend them for over 70s? As Malcolm Kendrick pointed out from other studies, if you take them for years they *may* extend your life by a few days.

    Malcolm Kendrick is a bit of a moveable feast, he now thinks heart disease is due to lack of sunshine and low vit D!

    He has hedged his bets somewhat on LDL as well!
    D.

    Agreed, l'm coming to the same conclusion. I got tired of his long drawn out heart series of posts, I wondered would I still be alive by the time he gave us the answers. Vit D may be a contributor, but smoking higher on the list, excessive booze, and let us not forget the main cause, a diet based on sugar. Over time I have noticed heart disease tends to run in families, as does cancer and dementia. Anyway, something is going to see us off, as long as I check out in one piece, that will do me. If I had a choice in the matter, a massive heart attack would be my number one choice. woot Let's face it, if I go down with dementia would anyone notice? there is more than a few think I'm batshit now.freakout


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    Type two diabetic-low carb diet (50 carbs per day) and two 500mg Metformin pills per day. Apart from diagnosis HbA1c almost 12-all HbA1c results none diabetic. For over eight years my diabetes medication has not changed. My weight has remained stable, I have suffered no ill effects from my diet whatsoever. Every blood test has proved, I took the right road to my diabetic salvation. For almost seven years, I have asked medical professionals and naysayers, how do I maintain non diabetic BG levels on two Metformin other than low carb ? The silence has been deafening !
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    chris c
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    Re: Statins for Primary Prevention

    Post by chris c on Fri Jan 06 2017, 23:32

    @graham64 wrote:
    Yes but if they prevent Alzheimers Cool : The use of statins could be a cheap and relatively easy way to ward off Alzheimer's disease. A new study in The Journal of the American Medical ... http://kticradio.com/abc_health/your-body-use-of-statins-to-ward-off-alzheimers-risk-abcid35837793/

    I ever so slightly doubt that! Next they'll be marketed as fixing broken legs.

    I suspect the glucose/insulin axis is behind many things. What causes it to break is pretty debatable but the way to fix it is pretty clear.


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