The Low Carb Diabetic

Promoting a low carb high fat lifestyle for the safe control of diabetes. Eat whole fresh food, more drugs are not the answer.


Welcome to the Low Carb Diabetic forum,have you signed up yet? if not then sign up and join us in the low carb community today!

    Risk of Myopathy Associated With DPP-4 Inhibitors in Combination With Statins:

    Share
    avatar
    graham64
    Member

    Status :
    Online
    Offline

    Male Posts : 2855
    Join date : 2014-08-10
    Location : Lancs

    Risk of Myopathy Associated With DPP-4 Inhibitors in Combination With Statins:

    Post by graham64 on Tue Dec 20 2016, 21:36

    This is just part of the conclusions from the full PDF

    To date, the literature provides little information on the potential mechanism that could underlie the muscular toxicity of DPP-4 inhibitors. It is suggested that these drugs may have pleiotropic effects and be implicated in lipid synthesis (9,10); if so, the mechanism could involve the cholesterol synthesis pathway, similar to that suspected for statins or fibrates.

    This study confirms a potential muscular toxicity of DPP-4 inhibitors and advocates for pharmacoepidemiological studies to be conducted in order to further explore this potential risk. Meanwhile, physicians and patients should remain vigilant concerning this putative risk, regardless of whether DPP-4 inhibitors are used in combination with statins.

    http://care.diabetesjournals.org/content/diacare/early/2016/12/19/dc16-1822.full.pdf

    Well that's more medications easily avoided by LC/HF, but of course LowCarb is unsafe best follow the high carb dietary guidelines for the benefits far outweigh the effects of toxic drugs  Rolling Eyes




    _________________
    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over nine years,

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
    avatar
    chris c
    Member

    Status :
    Online
    Offline

    Posts : 3003
    Join date : 2015-07-26

    Re: Risk of Myopathy Associated With DPP-4 Inhibitors in Combination With Statins:

    Post by chris c on Tue Dec 20 2016, 21:42

    Weren't they also associated with increased rates of some cancers? Or did they cover that up now?
    avatar
    graham64
    Member

    Status :
    Online
    Offline

    Male Posts : 2855
    Join date : 2014-08-10
    Location : Lancs

    Re: Risk of Myopathy Associated With DPP-4 Inhibitors in Combination With Statins:

    Post by graham64 on Tue Dec 20 2016, 22:02

    @chris c wrote:Weren't they also associated with increased rates of some cancers? Or did they cover that up now?

    Can't be sure but it would not surprise me in the least, I expect more problems will arise in the future, diabetics are unwittingly being used as guinea pigs testing the long term effects of Big Pharma's new drugs.


    _________________
    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over nine years,

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
    avatar
    chris c
    Member

    Status :
    Online
    Offline

    Posts : 3003
    Join date : 2015-07-26

    Re: Risk of Myopathy Associated With DPP-4 Inhibitors in Combination With Statins:

    Post by chris c on Wed Dec 21 2016, 22:59

    If I remember correctly (not always guaranteed, so many drugs so many side effects) statins not only lower "cholesterol" they knock out an entire metabolic pathway including such vital things as Co-Q10.

    DPP-4 not only eats incretins for breakfast but is also involved in a bunch of other pathways. No surprise that the combination would have some potentially dangerous effects.

    Modern medicine is all about marketing drugs that cut the tail off the snake, and then when it regrows in a different place there's another drug.

    What it SHOULD be about is finding the head of the snake, basically what LCHF does.

      Current date/time is Fri Jul 21 2017, 09:38