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    Proton Pump Inhibitors Decrease Diversity in Gut Microbiome, Increase Risk for Complications


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    Proton Pump Inhibitors Decrease Diversity in Gut Microbiome, Increase Risk for Complications

    Post by yoly on Wed Nov 26 2014, 11:44

    ROCHESTER, Minn. — Before reaching for that daily antacid, you might consider what it’s doing to the trillions of bugs living in your gut. A new Mayo Clinic study in the open access journal Microbiome shows that people who regularly take proton pump inhibitors (PPIs) have less diversity among their gut bacteria, putting them at increased risk for infections like clostridium difficile and pneumonia, in addition to vitamin deficiencies and bone fractures.

    MEDIA CONTACT: Sam Smith, Mayo Clinic Public Affairs, 507-284-5005, Email:

    Journalists: Soundbites with Dr. DiBaise are available in the downloads.

    “Evidence has been mounting for years that long-term use of proton pump inhibitors poses increased risks for a variety of associated complications, but we have never really understood why,” says John DiBaise, M.D., a Mayo Clinic gastroenterologist and senior author on the study. “What this study does for the first time is demonstrate a plausible explanation for these associated conditions.”

    The gut microbiome consists of trillions of bacteria. Rather than causing disease, most of these bacteria are friendly and aid in everything from digestion and vitamin synthesis to immune system regulation and possibly, mood stabilization.

    Diet, genetics and environmental exposure all play a role in maintaining a healthy microbiome, which is critical to overall wellness, says Dr. DiBaise. Significant changes to the microbiome, like those caused by proton pump inhibitors, can put people at risk for over-colonization by such undesirable species as clostridium difficile, he says.

    Proton pump inhibitors are primarily used to treat ulcers and acid reflux, and include the generic names omeprazole, pantoprazole, esomeprazole, lansoprazole, rabeprazole and dexlansoprazole.

    Many epidemiological studies have linked PPIs to nutritional, metabolic and infectious disorders, despite the class of drugs’ long history of safety and efficacy. Specifically, their prolonged use has been associated with iron and vitamin B12 deficiencies, hypomagnesemia, osteoporosis-related fractures, small intestinal bacterial overgrowth, and community-acquired pneumonia. The Food and Drug Administration has issued several safety communications about use of high-dose PPIs (available through prescription) and long-term use at any dose, including over-the-counter medications.

    Safety implications of the study have yet to be determined, and patients should consult a qualified medical professional before changing any drug regimen, says Dr. DiBaise.

    “We’re not saying people should stop taking their regular antacids; despite the many health risks associated with PPI use, they have an extensive track record of safety when used as directed,” Dr. DiBaise says. “What we are saying is that the medical and research communities should consider these medications in the context of the patient’s microbiome. This is an area that needs further study.”

    In patients with mild reflux symptoms, lifestyle changes may be sufficient to curb discomfort, Dr. DiBaise says. Non-pharmacological methods to control acid reflux include:

    Eat smaller portions at meals
    Consume less fat
    Avoid laying down for at least 2 hours after eating (avoid late-night snacks)
    Wear loose fitting clothing
    Elevate the head of the bed about 6 inches (this is best done by placing a block under the headboard, rather than stacking pillows)
    Lose weight (as little as 5 to 10 pounds may help)
    Avoid alcohol, tobacco and foods that trigger symptoms

    Daily medications become necessary in those whose reflux symptoms persist and impair their quality of life despite these lifestyle modifications, says Dr. DiBaise. Whether less potent acid inhibitors like histamine H2 antagonists, cause similar changes to the microbiome is unknown.

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    Re: Proton Pump Inhibitors Decrease Diversity in Gut Microbiome, Increase Risk for Complications

    Post by Eddie on Wed Nov 26 2014, 14:21

    Old hands on this forum have seen many people that suffered with acid reflux for years 'cured' within next to no time when going on a low carb high fat diet. Yet another reason to join the LCHF club.

    Type two diabetic-low carb diet (50 carbs per day) and two 500mg Metformin pills per day. Apart from diagnosis HbA1c almost 12-all HbA1c results none diabetic. For over eight years my diabetes medication has not changed. My weight has remained stable, I have suffered no ill effects from my diet whatsoever. Every blood test has proved, I took the right road to my diabetic salvation. For almost seven years, I have asked medical professionals and naysayers, how do I maintain non diabetic BG levels on two Metformin other than low carb ? The silence has been deafening !

      Current date/time is Tue May 22 2018, 18:52