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    Novel agent decreases neuropathic pain in patients with type 2 diabetes

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    yoly
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    Novel agent decreases neuropathic pain in patients with type 2 diabetes

    Post by yoly on Sat Dec 20 2014, 11:06

    http://www.medicalnewstoday.com/releases/287050.php?tw


    Molecular Medicine, a peer-reviewed biomedical journal published by the Feinstein Institute Press, published the results of a new study reporting clinically significant pain reduction in type 2 diabetic patients. In an exploratory study conducted by Araim Pharmaceuticals, a biotech company developing novel treatments for chronic diseases, investigators also observed improvements in metabolic control in patients administered ARA 290. ARA 290 is a peptide engineered to activate the innate repair receptor, a receptor discovered by Araim scientists, which is only expressed following tissue damage or stress.

    In the initial study, patients were administered ARA 290, a novel, first-in-class drug, daily for 28 days, with the purpose of evaluating its efficacy in treating neuropathic pain, a common condition among diabetics. When ARA 290 is administered, the repair receptor is activated and subsequently turns off inflammation and turns on the body's natural repair system. The short half-life of ARA 290, coupled with the restricted expression of the innate repair receptor, functions as a dual safety system to avoid potential side effects.

    "The results from this study indicate a major breakthrough in the treatment of diabetes," said Kevin J. Tracey, MD, president of the Feinstein Institute for Medical Research and Editor of Molecular Medicine. "Over the years, Molecular Medicine has prided itself on publishing groundbreaking papers with implications on the broader medical community, and we're proud to have a potential disease-modifying solution to diabetes featured in the current issue."

    The clinically significant results and excellent safety profile support Araim's development strategy of two future studies in 2015. First, metabolic improvement will be studied in type 2 diabetics with moderate kidney damage. Second, neuropathic pain reduction will be assessed in a multi-center proof of concept trial in type 1 diabetics. Both phase 2 clinical trials will be conducted in the United Kingdom, and patients will be dosed daily for six months to allow time for adequate tissue repair.

    "We're excited to be on the cusp of the first diabetic disease modifier that demonstrates the potential to repair the complications of diabetes systemically," said Anthony Cerami, PhD, CEO of Araim Pharmaceuticals." Dr. Cerami developed the HbA1c diagnostic test, the current gold standard for diagnosing diabetes.
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    AliB
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    Re: Novel agent decreases neuropathic pain in patients with type 2 diabetes

    Post by AliB on Sat Dec 20 2014, 20:59

    Interestng Yoly, thanks, but guess what?

    A low carb diet removes not just the pain but the neuropathy too.

    This is yet another 'treat the symptom, not the cause drug'.

    The digestive process takes a huge amount of vital energy and nutrition. A good digestive process uses far less of both than a bad one. A digestive process that uses more nutrition than what is being ingested leads to degeneration. Insulin resistance leading to high sugar levels in the body leads to malnutrition as the body cannot process or utilise certain elements. Diabetic 'complications' and degeneration is nothing more than a result of malnutrition.

    When a good digestive process reverses the malnutrition and reinstates the building blocks needed for healing and repair, the body can heal and repair.

    All the time, science is treating the sugar issue, or the sugar effects on the body rather than encouraging people to address the root cause.

      Current date/time is Fri Jul 21 2017, 07:50