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    Diabetes and Thiamine: A Novel Treatment Opportunity

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    yoly
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    Diabetes and Thiamine: A Novel Treatment Opportunity

    Post by yoly on Wed Oct 22 2014, 11:03

    (Don't expect thiamine is going to cure your diabetes but it may help prevent complications. Just something to consider along with your low carb diet, exercise and any other medication you may require.)

    http://www.hormonesmatter.com/diabetes-thiamine-treatment-opportunity/

    Tuesday, August 5th, 2014 / Chandler Marrs, PhD

    Underlying all diabetic conditions is poor sugar control or hyperglycemia. Hyperglycemia can be due to a lack of insulin as in Type 1 diabetes or insulin resistance as in Type 2 diabetes. In either case, the corresponding diabetic complications that evolve over time in many diabetics, the cardiovascular disease, retinopathy, peripheral nerve and vascular damage, represent the effects of sustained hyperglycemia. Until recently, the mechanisms by which diabetic vascular damage developed eluded researchers. Although multiple, seemingly discrete biomarkers had been identified, no single, unifying mechanism was understood. It turns out that diabetics, both Type 1 and Type 2, are severely deficient in thiamine or vitamin B1 and that thiamine is required for glucose control at the cell level. Why is thiamine deficient in diabetics and how does thiamine manage glucose control? The answers to those questions highlight the importance of micronutrients in basic cellular functioning, particularly mitochondrial functioning, and the role of excessive sugar in disease.

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    Consider the implications of thiamine deficiency, a single micronutrient available in food, on cellular health, and indeed, physical health. In addition its role in mitochondrial functioning, thiamine controls sugar metabolism through multiple pathways. Inefficient sugar metabolism leads to disease. Thiamine also regulates the metabolism of fatty acids and provides the necessary substrates for the neurotransmitters acetylcholine and GABA. Thiamine, much like other critical nutrients, is not only absent from the largely processed diets of modernity, but at every turn, can be depleted by medications and environmental toxicants. Against the backdrop of nutrient depleted and damaged mitochondria, accommodating medications, vaccines and environmental toxicants that also damage mitochondria, increase oxidative stress and further deplete critical nutrients, it is no wonder we are living sicker and dying younger than ever before. The depletion of critical nutrients is causing disease; diseases no medication can treat.

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    http://www.ncbi.nlm.nih.gov/pubmed/18581039

    Abstract

    Thiamine (vitamin B1) is an essential cofactor in most organisms and is required at several stages of anabolic and catabolic intermediary metabolism, such as intracellular glucose metabolism, and is also a modulator of neuronal and neuro-muscular transmission. Lack of thiamine or defects in its intracellular transport can cause a number of severe disorders. Thiamine acts as a coenzyme for transketolase (TK) and for the pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase complexes, enzymes which play a fundamental role for intracellular glucose metabolism. In particular, TK is able to shift excess fructose-6-phosphate and glycerhaldeyde-3-phosphate from glycolysis into the pentose-phosphate shunt, thus eliminating these potentially damaging metabolites from the cytosol. Diabetes might be considered a thiamine-deficient state, if not in absolute terms at least relative to the increased requirements deriving from accelerated and amplified glucose metabolism in non-insulin dependent tissues that, like the vessel wall, are prone to complications. A thiamine/TK activity deficiency has been described in diabetic patients, the correction of which by thiamine and/or its lipophilic derivative, benfotiamine, has been demonstrated in vitro to counteract the damaging effects of hyperglycaemia on vascular cells. Little is known, however, on the positive effects of thiamine/benfotiamine administration in diabetic patients, apart from the possible amelioration of neuropathic symptoms. Clinical trials on diabetic patients would be necessary to test this vitamin as a potential and inexpensive approach to the prevention and/or treatment of diabetic vascular complications.
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    mo1905
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    Re: Diabetes and Thiamine: A Novel Treatment Opportunity

    Post by mo1905 on Wed Oct 22 2014, 11:21

    Interesting, is thiamine available as a supplement or is it prevalent in certain foods ?


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    Dillinger
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    Re: Diabetes and Thiamine: A Novel Treatment Opportunity

    Post by Dillinger on Wed Oct 22 2014, 11:27

    Hello,

    Thiamine is vitamin B1 - there are various types of it available including thiamine and benfortiamine for instance.

    If you scroll down here there is lots of info:

    http://www.phlaunt.com/diabetes/20144672.php

    Note that they say "More recent research is casting doubt on whether benfortiamine is, actually, oil soluble and whether it has any value compared to much less expensive thiamine."

    I take thiamine every day.

    Best

    Dillinger
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    mo1905
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    Re: Diabetes and Thiamine: A Novel Treatment Opportunity

    Post by mo1905 on Wed Oct 22 2014, 11:31

    Thanks Dillinger, great info.


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    Type1, Humalog and Solostar, Metformin, Lisinopril ( BP ), last HbA1C 41 ( 5.9% ), 20th Oct 2014, HbA1C 43 ( 6.1% ) 9th Mar 2015.
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    AliB
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    Re: Diabetes and Thiamine: A Novel Treatment Opportunity

    Post by AliB on Wed Oct 22 2014, 12:55

    Subclinical Beri-Beri is actually a big problem.

    The low-level symptoms are not high enough on the radar to be picked up by the Medical Profession.  They rarely recognise anything until it's 'full-blown' - as if it happened over night......

    When I was on Bee's diet, she asked us to start adding in extra Thiamin.  200mg per day.  I added the whole 200 and my body went bonkers!  Cutting down to 50mgs and gradually increasing it got it up to the full 200mg over about a week and that was ok.

    What that told me was my body was desperate for it.  I had a lot of the symptoms of subclinical Dry Beri-Beri.

    As my digestion and presumably flora has improved, my need for it has lowered.  Maybe my microbiome is now producing more of its own.....?
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    AliB
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    Re: Diabetes and Thiamine: A Novel Treatment Opportunity

    Post by AliB on Wed Oct 22 2014, 13:07


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