The Low Carb Diabetic

Promoting a low carb high fat lifestyle for the safe control of diabetes. Eat whole fresh food, more drugs are not the answer.


Welcome to the Low Carb Diabetic forum,have you signed up yet? if not then sign up and join us in the low carb community today!

    Beta cell stress in a 4‐year follow‐up of patients with type 2 diabetes

    Share
    graham64
    graham64
    Member

    Status :
    Online
    Offline

    Male Posts : 3730
    Join date : 2014-08-10
    Location : Lancs

    Beta cell stress in a 4‐year follow‐up of patients with type 2 diabetes

    Post by graham64 on Tue May 22 2018, 22:17

    Abstract

    Background
    Type 2 diabetes mellitus (T2DM) is associated with a progressive deterioration in beta cell function and loss of glycaemic control. Clinical predictors of beta cell failure are needed to guide appropriate therapy.

    Methods
    A prospective evaluation of a large set of potential predictors of beta cell stress, measured as change in the proinsulin/insulin (PI/I) ratio, was conducted in a cohort of 235 outpatients with T2DM on stable treatment with oral hypoglycaemic agents or diet followed up for ~4 years (median value 3.9 years; interquartile range 3.8‐4.1 years).

    Results
    Overall, metabolic control deteriorated over time, with a significant increase in glycated haemoglobin (HbA1c; P < .0001), proinsulin (P < .0001), and PI/I ratio (P = .001), without significant changes in the homeostatic model assessment of insulin resistance. Multivariate regression analysis showed that for each 1% (10.9 mmol/mol) increase from baseline in HbA1c, the risk of beta cell stress increased by 3.8 times; for each 1% (10.9 mmol/mol) incremental increase in HbA1c during the study, risk of beta cell stress increased by 2.25 times that at baseline. By contrast, baseline anthropometric and clinical variables, lipid profile, inflammatory markers (PCR, IL‐6), non‐esterified fatty acids, and current therapies did not independently influence PI/I ratio variation during follow‐up.

    Conclusions
    In this cohort of patients with T2DM, beta cell function progressively deteriorated despite current therapies. Among a large set of clinical and biochemical predictors, only baseline HbA1c levels and their deterioration overtime were associated with higher beta cell stress over time.

    Full text: https://onlinelibrary.wiley.com/doi/full/10.1002/dmrr.3016

    Listen to your dietitian follow the T2 guidelines take the drugs and you've got diabetes progression, alternatively ignore dietitian and guidelines and go low carb and get stability not progression  Smile


    _________________
    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over ten years

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
    yoly
    yoly
    Member

    Status :
    Online
    Offline

    Posts : 624
    Join date : 2014-08-14

    Re: Beta cell stress in a 4‐year follow‐up of patients with type 2 diabetes

    Post by yoly on Wed May 23 2018, 13:52

    No drugs including insulin without reducing your intake of carbohydrates is going to give you "control". So they set for "control" targets that really aren't control and then wonder why it still progress. That said in old people everything "progress" we all going to die of something. But the diabetics complications because bad advice aren't the best way to go. Many if not all can be avoided with good diabetes management.
    Jan1
    Jan1
    Member

    Status :
    Online
    Offline

    Female Posts : 4992
    Join date : 2014-08-13

    Re: Beta cell stress in a 4‐year follow‐up of patients with type 2 diabetes

    Post by Jan1 on Wed May 23 2018, 17:18

    I know I am not a diabetic ...
    But I do agree with the words " go low carb and get stability not progression"

    I am sure there are many, many diabetics who would agree Smile  

    All the best Jan
    chris c
    chris c
    Member

    Status :
    Online
    Offline

    Posts : 4520
    Join date : 2015-07-26

    Re: Beta cell stress in a 4‐year follow‐up of patients with type 2 diabetes

    Post by chris c on Wed May 23 2018, 22:05

    pdf

    http://sci-hub.hk/10.1002/dmrr.3016

    Yes there must by now be thousands if not hundreds of thousands of diabetics who are failing to progress satisfactorily, just like they used to do in the past.
    graham64
    graham64
    Member

    Status :
    Online
    Offline

    Male Posts : 3730
    Join date : 2014-08-10
    Location : Lancs

    Re: Beta cell stress in a 4‐year follow‐up of patients with type 2 diabetes

    Post by graham64 on Wed May 23 2018, 22:34

    @chris c wrote:pdf

    http://sci-hub.hk/10.1002/dmrr.3016

    Yes there must by now be thousands if not hundreds of thousands of diabetics who are failing to progress satisfactorily, just like they used to do in the past.

    It's an open access study Chris the PDF is available too: https://onlinelibrary.wiley.com/doi/epdf/10.1002/dmrr.3016


    _________________
    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over ten years

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
    chris c
    chris c
    Member

    Status :
    Online
    Offline

    Posts : 4520
    Join date : 2015-07-26

    Re: Beta cell stress in a 4‐year follow‐up of patients with type 2 diabetes

    Post by chris c on Wed May 23 2018, 22:38

    Oh strange I got the study but not the pdf

    Must be the Alzheimers . . .

    Sponsored content

    Re: Beta cell stress in a 4‐year follow‐up of patients with type 2 diabetes

    Post by Sponsored content


      Current date/time is Thu Jan 24 2019, 01:55