The Low Carb Diabetic

Promoting a low carb high fat lifestyle for the safe control of diabetes. Eat whole fresh food, more drugs are not the answer.


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    Even More Science

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    chris c
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    Even More Science

    Post by chris c on Sun Oct 22 2017, 23:48

    Some of these I may have posted already but I can't remember which.

    I have been collecting papers from the incredibly prolific Kendrick Crew and from not a few other blogs and Twitter accounts, and finally got around to reading most of them. It's been like going back to college except without the drugs and beer.

    Terminal cluelessness by the Usual Suspects, including DUK.

    https://twitter.com/zoeharcombe/status/897038655356841985

    Back in the day "Double Diabetes" was rare and usually caused by eg. steroid use, or the long term damage from misdiagnosing Type 1 as Type 2 and failing to control it with the usual Type 2 drugs before finally going on to the appropriate insulin.

    Now I've read from several sources that it has become quite common for Type 1s to develop IR and go on to have all kinds of highly profitable Type 2 drugs prescribed along with their insulin - it used to be that metformin along with an LC diet usually sufficed.

    Zoe even posts this paper

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671104/

    and DUK denies it.

    Now I have this to read

    http://care.diabetesjournals.org/content/31/Supplement_2/S262

    A couple looking at high fat vs. high carb diets

    http://ajcn.nutrition.org/content/77/1/43.full

    http://sci-hub.bz/10.3945/ajcn.115.123463

    CVD risk even in "prediabetes"

    http://care.diabetesjournals.org/content/diacare/early/2013/09/16/dc13-1374.full.pdf

    DON'T spike that glucose whatever your doctor, or Giles Yeo, tells you about it being "perfectly normal"

    Are you sure you want to eat those "heart healthy" vegetable oils?

    http://www.jbc.org/content/287/14/11398.short

    Are you quite sure?

    http://m.ajpheart.physiology.org/content/287/6/H2518.long?view=long&pmid=15284064

    More from PURE

    http://sci-hub.bz/10.1161/CIRCRESAHA.117.308903

    http://sci-hub.bz/10.1161/CIRCRESAHA.117.311849

    Some more about "cholesterol"

    http://sci-hub.bz/10.2165/11319590-000000000-00000

    http://atvb.ahajournals.org/content/17/12/3542.long

    lots of great links including Ron Krauss & co.

    http://circ.ahajournals.org/content/118/20/2047.long

    Krauss himself, from 1988

    http://sci-hub.bz/10.1001/jama.1988.03410130125037

    http://cholesterolcode.com/beyond-the-lipid-hypothesis-plaque-development/

    The whole cholesterolcode blog is worth a read, there's a whole lot of stuff going on while no-one is looking!

    If I ever find time I'm going to use Sci-Hub to finally read some of the classic Gerald Reaven and Krauss etc. papers which are STILL paywalled decades after they were published. Clearly They don't want you to know this stuff.

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    Re: Even More Science

    Post by chris c on Thu Oct 26 2017, 23:49

    Does the evidence support population-wide screening for type 2 diabetes? No

    https://link.springer.com/article/10.1007/s00125-017-4393-1

    Maybe it would be worthwhile if they stopped telling diabetics to eat more starch and a low fat diet. Just a thought.

    Insulin Resistance and Hyperinsulinemia

    http://care.diabetesjournals.org/content/31/Supplement_2/S262

    Prostaglandins and Other Lipid Mediators

    Prevent the cause, not just the symptoms

    http://sci-hub.bz/10.1016/j.prostaglandins.2011.07.003

    more from the always excellent Bill Lands

    Dietary Intervention for Overweight and Obese Adults: Comparison of Low-Carbohydrate and Low-Fat Diets. A Meta-Analysis

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618935/

    Relative Intake of Macronutrients Impacts Risk of Mild Cognitive Impairment or dementia

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494735/#!po=33.8710

    hint: what diet are old folks routinely given especially in care homes? High carb low fat low protein.

    While the Dietician Hordes and their vegan pals and Conventional Wisdom doctors are busily trashing PURE, they should look behind them

    Food consumption and the actual statistics of cardiovascular diseases: an epidemiological comparison of 42 European countries

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040825/

    this was from last year

    "Conclusion
    Our results do not support the association between CVDs and saturated fat, which is still contained in official dietary guidelines. Instead, they agree with data accumulated from recent studies that link CVD risk with the high glycaemic index/load of carbohydrate-based diets. In the absence of any scientific evidence connecting saturated fat with CVDs, these findings show that current dietary recommendations regarding CVDs should be seriously reconsidered."

    "Irrespective of the possible limitations of the ecological study design, the undisputable finding of our paper is the fact that the highest CVD prevalence can be found in countries with the highest carbohydrate consumption, whereas the lowest CVD prevalence is typical of countries with the highest intake of fat and protein. The polarity between these geographical patterns is striking"

    I expect absolutely nothing to change.
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    Re: Even More Science

    Post by chris c on Wed Nov 08 2017, 23:53

    A few more from various sources

    http://www.molmetab.com/article/S2212-8778(17)30194-1/fulltext?rss=yes

    Hmmm, now I wonder how else you can affect glucagon and leptin. It's on the tip of my tongue. Basically looks like a complex and profitable way to induce the effects of a low carb diet without actually eating a low carb diet.

    A great piece of history looking at MToR and what it actually does

    http://www.pnas.org/content/114/45/11818.full

    "The mechanisms that regulate organismal growth and coordinate it with the availability of nutrients were unknown until a few decades ago. We now know that one pathway—the mechanistic target of rapamycin (mTOR) pathway—is the major nutrient-sensitive regulator of growth in animals and plays a central role in physiology, metabolism, the aging process, and common diseases. This work describes the development of the mTOR field, from its origins in studies into the mechanism of action of the drug rapamycin to our increasingly sophisticated understanding of how nutrients are sensed."

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363366/

    You can't outrun a bad diet, but exercise may help against inflammation. Of course so might NOT eating inflammatory quantities of "vegetable" oils.

    Interesting stuff about the timing of endocrine responses over the course of a day

    http://sci-hub.bz/10.1038/nrendo.2014.78

    An interesting look at new ways to explain diabetes, without mentioning carbohydrate once

    http://sci-hub.bz/10.1016/j.tem.2017.05.005

    "Disclaimer Statement
    S.S.S. is a speaker and advisor to Novo Nordisk, Merck, Takeda, Johnson & Johnson, Astra-Zeneca/Bristol-Myers
    Squibb, Eli Lilly and Company, Boehringer Ingelheim/Eli Lilly and Company, and is a speaker for Eisai and GlaxoSmithKline.
    J.R.G. has received consultant fees from Abbott Diabetes Care, Intarcia Pharmaceuticals, Astra Zeneca, and Novo
    Nordisk; and has served on the advisory boards of Janssen Pharmaceuticals and Astra Zeneca, and on the speaker’s
    bureaus of Astra Zeneca, Janssen, and Boehringer Ingelheim/Eli Lilly and Company. R.B.A. sits on the advisory board and
    speaker’s bureaus of Eli Lilly and Company, Boehringer Ingelheim, Janssen, and Takeda. No potential conflicts of interest
    relevant to this article were reported."

    Well that explains a lot. Barbara Corkey is usually more sensible, she's about the only author here without any COI.

    Oh look, the BDA who go apeshit when anyone "cuts out entire food groups" like grains or sugar, yet encourage avoidance of fat and meat, come clean

    https://www.bda.uk.com/about/workwithus/bda_and_vegan_society_mou

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    Re: Even More Science

    Post by chris c on Mon Nov 13 2017, 23:07

    Stay strong, and eat your protein

    http://ajcn.nutrition.org/content/84/3/475.long

    Don't trash your mitochondria

    http://www.jbc.org/content/284/21/14087.full

    This look a bit like low carb in a pill

    http://www.clinsci.org/content/131/20/2489


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