Saturated fats and cardiovascular disease risk: A review

Saturated fats have been in the line of fire for more than three decades. The major mistake in understanding fats was to equate all saturated fatty acids as one. The oversimplification of the relationship of saturated fats with cardiovascular disease (CVD) led to unwarranted removal of some valuable fats from our diets. Recently, the relationship of dietary saturated fats and that of individual saturated fatty acids (SFAs) to CVD risk has been reevaluated. All saturated fats are not equal and these fats are not as bad as they are made out to be. Thus, not all SFAs in natural fats are atherogenic (formation of fatty deposits in arteries). Butter, clarified butter (desi ghee), coconut oil, and palm oil as a part of a healthy diet are not contraindicated. The review of literature clearly suggests a relook at saturated fats with respect to atherogenicity and over health.

Full text: http://www.jcpconline.org/article.asp?issn=2250-3528;year=2017;volume=6;issue=2;spage=56;epage=59;aulast=Khosla

But . . . but . . . but . . . the "science" is settled according to David Katz. It's perfectly simple, saturated fat causes heart disease because animals. Meat causes diabetes and cancer because animals. Sugar is good because it is low fat and vegan. Coke is good because it is plant based (industrial plant). THIS MUST NOT BE QUESTIONED BY SO-CALLED SCIENTISTS.

These people are clearly backed by the meat and dairy industry. Obviously if they were backed by ILSI, PCRM and CSPI there would be no conflict of interest.

http://sustainablefoodtrust.org/articles/understanding-fats/


I'll read this one later. First I need to eat some cheese.

chris c wrote:These people are clearly backed by the meat and dairy industry. Obviously if they were backed by ILSI, PCRM and CSPI there would be no conflict of interest.

It does actually state: Financial support and sponsorship Nil.

Conflicts of interest There are no conflicts of interest.

They insist you take statins then, as in my case, they give you a drug for bp that causes CVD and heart failure. Doxazosin, ALLHAT in 2000 said it was nbg! D.

Derek wrote:They insist you take statins  then, as in my case, they give you a drug for bp that causes CVD and heart failure. Doxazosin, ALLHAT in 2000 said it was nbg!  D.

After you mentioned Doxazosin I checked it out From here https://www.drugs.com/sfx/doxazosin-side-effects.html

In addition to its needed effects, some unwanted effects may be caused by doxazosin. In the event that any of these side effects do occur, they may require medical attention.
Severity: Moderate
If any of the following side effects occur while taking doxazosin, check with your doctor or nurse as soon as possible:
More common:
Dizziness or lightheadedness
Less common:
Blurred vision
confusion
dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
fainting (sudden)
fast and pounding heartbeat
irregular heartbeat
shortness of breath
sweating
swelling of feet or lower legs
Rare
Painful or prolonged erection of the penis (called priapism), although extremely rare, must have immediate medical attention. If painful or prolonged erection occurs, call your doctor or go to an emergency room as soon as possible
Incidence not known:
Abdominal or stomach pain
area rash
black, tarry stools
bleeding gums
blood in urine or stools
chest pain or discomfort
chills
clay-colored stools
cough
dark urine
diarrhea
difficulty breathing
difficult, burning, or painful urination
fever
general tiredness and weakness
headache, sudden and severe
inability to speak
itching
lab results that show problems with liver
light-colored stools
loss of appetite
noisy breathing
pain or discomfort in arms, jaw, back or neck
pinpoint red or purple spots on skin
rash
seizures
slow or irregular heartbeat
slurred speech
sore throat
sores, ulcers, or white spots on lips or in mouth
swollen glands
temporary blindness
tightness in chest
unpleasant breath odor
unusual bleeding or bruising
upper right abdominal pain
vomiting
vomiting of blood
weakness in arm and/or leg on one side of the body, sudden and severe
wheezing
yellow eyes and skin
Minor Side Effects
Some of the side effects that can occur with doxazosin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
More common:
Headache
lack or loss of strength
unusual tiredness or weakness
Less common:
Acid or sour stomach
back pain
belching
bladder pain
cloudy urine
difficulty in moving
frequent urge to urinate
heartburn
indigestion
joint pain
lower back or side pain
muscle aching, cramping, or weakness
muscle pains or stiffness
nausea
nervousness, restlessness, unusual irritability
runny nose
sleepiness or drowsiness
sneezing
sore throat
stomach discomfort, upset or pain
swollen joints
Incidence not known:
Anxiety
burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feeling
change in frequency or urination
dry mouth
feeling of warmth
frequent urination
general feeling of discomfort or illness
hair loss
hives or welts
hyperventilation
increased urge to urinate during the night
increased volume of pale dilute urine
loss of appetite
painful urination
redness of skin
redness of the face, neck, arms and occasionally upper chest
shaking
swelling of the breasts or breast soreness in both females and males
thinning of hair
trouble in holding or releasing urine
trouble sleeping
waking to urinate at night
weight loss

Thanks Eddie
D.

Eddie wrote:

Derek wrote:They insist you take statins  then, as in my case, they give you a drug for bp that causes CVD and heart failure. Doxazosin, ALLHAT in 2000 said it was nbg!  D.

After you mentioned Doxazosin I checked it out    From here https://www.drugs.com/sfx/doxazosin-side-effects.html

In addition to its needed effects, some unwanted effects may be caused by doxazosin. In the event that any of these side effects do occur, they may require medical attention.
Severity: Moderate
If any of the following side effects occur while taking doxazosin, check with your doctor or nurse as soon as possible:
More common:
Dizziness or lightheadedness
Less common:
Blurred vision
confusion
dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
fainting (sudden)
fast and pounding heartbeat
irregular heartbeat
shortness of breath
sweating
swelling of feet or lower legs
Rare
Painful or prolonged erection of the penis (called priapism), although extremely rare, must have immediate medical attention. If painful or prolonged erection occurs, call your doctor or go to an emergency room as soon as possible
Incidence not known:
Abdominal or stomach pain
area rash
black, tarry stools
bleeding gums
blood in urine or stools
chest pain or discomfort
chills
clay-colored stools
cough
dark urine
diarrhea
difficulty breathing
difficult, burning, or painful urination
fever
general tiredness and weakness
headache, sudden and severe
inability to speak
itching
lab results that show problems with liver
light-colored stools
loss of appetite
noisy breathing
pain or discomfort in arms, jaw, back or neck
pinpoint red or purple spots on skin
rash
seizures
slow or irregular heartbeat
slurred speech
sore throat
sores, ulcers, or white spots on lips or in mouth
swollen glands
temporary blindness
tightness in chest
unpleasant breath odor
unusual bleeding or bruising
upper right abdominal pain
vomiting
vomiting of blood
weakness in arm and/or leg on one side of the body, sudden and severe
wheezing
yellow eyes and skin
Minor Side Effects
Some of the side effects that can occur with doxazosin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
More common:
Headache
lack or loss of strength
unusual tiredness or weakness
Less common:
Acid or sour stomach
back pain
belching
bladder pain
cloudy urine
difficulty in moving
frequent urge to urinate
heartburn
indigestion
joint pain
lower back or side pain
muscle aching, cramping, or weakness
muscle pains or stiffness
nausea
nervousness, restlessness, unusual irritability
runny nose
sleepiness or drowsiness
sneezing
sore throat
stomach discomfort, upset or pain
swollen joints
Incidence not known:
Anxiety
burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feeling
change in frequency or urination
dry mouth
feeling of warmth
frequent urination
general feeling of discomfort or illness
hair loss
hives or welts
hyperventilation
increased urge to urinate during the night
increased volume of pale dilute urine
loss of appetite
painful urination
redness of skin
redness of the face, neck, arms and occasionally upper chest
shaking
swelling of the breasts or breast soreness in both females and males
thinning of hair
trouble in holding or releasing urine
trouble sleeping
waking to urinate at night
weight loss

But apart from that the drugs ok right?

There's a discussion forum covering Doxazosin on Patient UK

https://patient.info/forums/discuss/browse/doxazosin-2703

Judas F Priest!!!

And they say low carb is dangerous.

"It does actually state: Financial support and sponsorship Nil.

Conflicts of interest There are no conflicts of interest."

I know, I was just channelling the idiocy the likes of Carby McCarbface come out with when facts get in the way of their dogma.

More

http://www.medscape.com/viewarticle/875261

http://www.medpagetoday.com/Cardiology/Prevention/63150

The Truth Is Out There

chris c wrote:Judas F Priest!!!

And they say low carb is dangerous.

"It does actually state: Financial support and sponsorship Nil.

Conflicts of interest There are no conflicts of interest."

I know, I was just channelling the idiocy the likes of Carby McCarbface come out with when facts get in the way of their dogma.

More

http://www.medscape.com/viewarticle/875261

http://www.medpagetoday.com/Cardiology/Prevention/63150

The Truth Is Out There

The final paragraph in that medscape article says it all


The debate over the cholesterol hypothesis has continued because the results of cholesterol lowering interventions are inconsistent and contradictory. Nevertheless, clinical guidelines continue to emphasise the critical importance of cholesterol lowering to prevent CHD. Unfortunately, I believe this one-dimensional approach may have impeded the advancement of science and our search for other preventive strategies. The ACCELERATE trial may well herald our tipping point and a sea change in our approach to CHD prevention.

Yes it's good when that sort of thing makes it into Medscape. Doctors might actually read it. Dieticians, not so much.

chris c wrote:Yes it's good when that sort of thing makes it into Medscape. Doctors might actually read it. Dieticians, not so much.

Dietitians don't read at all they come off a production line pre programmed

Sadly too many doctors and nurses also have been suckered into what they are told is "Evidence Based Medicine" which is actually more like marketing-based marketing.

Yet another factor that has been ignored in the battle against cholesterol

http://www.sciencedirect.com/science/article/pii/S0925443915000241

Polyunsaturated fatty acids are susceptible to peroxidation and they yield various degradation products, including the main α,β-unsaturated hydroxyalkenal, 4-hydroxy-2,3-trans-nonenal (HNE) in oxidative stress. Due to its high reactivity, HNE interacts with various macromolecules of the cell, and this general toxicity clearly contributes to a wide variety of pathological conditions. In addition, growing evidence suggests a more specific function of HNE in electrophilic signaling as a second messenger of oxidative/electrophilic stress. It can induce antioxidant defense mechanisms to restrain its own production and to enhance the cellular protection against oxidative stress. Moreover, HNE-mediated signaling can largely influence the fate of the cell through modulating major cellular processes, such as autophagy, proliferation and apoptosis. This review focuses on the molecular mechanisms underlying the signaling and regulatory functions of HNE. The role of HNE in the pathophysiology of cancer, cardiovascular and neurodegenerative diseases is also discussed.

James D Nicolantonio is always worth a read too

http://openheart.bmj.com/content/1/1/e000032

Here's Belinda Fettke among others

http://www.nutritionforlife.healthcare/blog/lchf-our-approach-to-type-2-diabetes-management

Now I wonder where this will lead

https://www.sciencedaily.com/releases/2017/03/170327142820.htm

One of these compounds, designed and optimized by TSRI scientists, significantly improves the health of diabetic animal models by reducing glucose levels in the blood, increasing insulin sensitivity and improving glucose balance.

Hmmm, I did that through LCHF

John Yudkin was a man decades ahead of his time. He was one of the first scientists to warn of the dangers of sugar and highly refined carbohydrates. He became internationally famous with his book Pure, White and Deadly (published in English in 1972, with new editions in 1986 and 2012). I first heard of Yudkin when reading a Gary Taubes book an extract below re. Yudkin.

“The George McGovern’s Senate Select Committee on Nutrition and Human Needs 1973.

Peter Cleave testified to his belief that the problem extended to all refined carbohydrates. “I don’t hold the cholesterol view for a moment,” Cleave said, noting that mankind had been eating saturated fats for hundreds of thousands of years. “For a modern disease to be related to an old fashioned food is one of the most ludicrous things I have ever heard in my life,” Cleave said. “if anybody tells me that eating fat was the cause of coronary disease, I should look at them in amazement. But, when it comes to the dreadful sweet things that are served up … that is a very different proposition.” Yudkin blamed heart disease exclusively on sugar, and he was equally adamant that neither saturated fat nor cholesterol played a role. He explained how carbohydrates and specifically sugar in the diet could induce both diabetes and heart disease, through their effect on insulin secretion and the blood fats known as triglycerides. McGovern now struggled with the difficulty of getting some consensus on these matters.

“Are you saying that you don’t think a high fat intake produces the high cholesterol count?” McGovern asked Yudkin. “Or are you even saying that a person with high cholesterol count is not in great danger?”

“Well, I would like to exclude those rare people who have probably a genetic condition in which there is an extremely high cholesterol,” Yudkin responded. “If we are talking about the general population, I believe both those things that you say. I believe that decreasing the fat in the diet is not the best way of combating a high blood cholesterol …. I believe that the high blood cholesterol in itself has nothing whatever to do with heart disease.” “That is exactly opposite what my doctor told me,” said McGovern.

Extract taken from the brilliant book ‘The Diet Delusion’ by Gary Taubes page 123 a must read for anyone with an interest in weight loss and controlling diabetes.

Yes indeed. Then there were the likes of Joseph Kraft (died recently in his nineties, and interviewed by the incomparable Ivor Cummins on The Fat Emperor a few years back), Fred Kummerow, still going over 100 I believe, Mary Enig, Gerald Reaven (most of whose papers are still paywalled), Ron Krauss, past president of the AHA, and many many more whose work is now being picked up and developed by current researchers.

Meanwhile

http://www.heraldscotland.com/news/15227240.Government_food_adviser_in_row_over_paid_links_to_sweets_and_fizzy_drinks_companies/#comments-anchor

https://patient.info/diabetes

barf bag required

http://us8.campaign-archive1.com/?u=63db7e07d57f8417546cdcec9&id=8819a57cad

scroll down the the bottom of the page

versus

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504183/pdf/nihms396311.pdf

http://www.onlinejacc.org/content/43/5/731