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    Saturated fats and cardiovascular disease risk: A review

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    graham64
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    Saturated fats and cardiovascular disease risk: A review

    Post by graham64 on Thu Apr 06 2017, 23:29

    Saturated fats have been in the line of fire for more than three decades. The major mistake in understanding fats was to equate all saturated fatty acids as one. The oversimplification of the relationship of saturated fats with cardiovascular disease (CVD) led to unwarranted removal of some valuable fats from our diets. Recently, the relationship of dietary saturated fats and that of individual saturated fatty acids (SFAs) to CVD risk has been reevaluated. All saturated fats are not equal and these fats are not as bad as they are made out to be. Thus, not all SFAs in natural fats are atherogenic (formation of fatty deposits in arteries). Butter, clarified butter (desi ghee), coconut oil, and palm oil as a part of a healthy diet are not contraindicated. The review of literature clearly suggests a relook at saturated fats with respect to atherogenicity and over health.

    Full text: http://www.jcpconline.org/article.asp?issn=2250-3528;year=2017;volume=6;issue=2;spage=56;epage=59;aulast=Khosla


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    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over nine years,

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
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    chris c
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    Re: Saturated fats and cardiovascular disease risk: A review

    Post by chris c on Fri Apr 07 2017, 00:55

    But . . . but . . . but . . . the "science" is settled according to David Katz. It's perfectly simple, saturated fat causes heart disease because animals. Meat causes diabetes and cancer because animals. Sugar is good because it is low fat and vegan. Coke is good because it is plant based (industrial plant). THIS MUST NOT BE QUESTIONED BY SO-CALLED SCIENTISTS.

    These people are clearly backed by the meat and dairy industry. Obviously if they were backed by ILSI, PCRM and CSPI there would be no conflict of interest.

    http://sustainablefoodtrust.org/articles/understanding-fats/


    I'll read this one later. First I need to eat some cheese.
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    graham64
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    Re: Saturated fats and cardiovascular disease risk: A review

    Post by graham64 on Fri Apr 07 2017, 22:02

    @chris c wrote:These people are clearly backed by the meat and dairy industry. Obviously if they were backed by ILSI, PCRM and CSPI there would be no conflict of interest.

    It does actually state: Financial support and sponsorship Nil.

    Conflicts of interest There are no conflicts of interest.


    _________________
    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over nine years,

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
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    Derek
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    Re: Saturated fats and cardiovascular disease risk: A review

    Post by Derek on Sat Apr 08 2017, 10:23

    They insist you take statins then, as in my case, they give you a drug for bp that causes CVD and heart failure. Doxazosin, ALLHAT in 2000 said it was nbg! D.
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    Eddie
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    Re: Saturated fats and cardiovascular disease risk: A review

    Post by Eddie on Sat Apr 08 2017, 11:45

    @Derek wrote:They insist you take statins  then, as in my case, they give you a drug for bp that causes CVD and heart failure. Doxazosin, ALLHAT in 2000 said it was nbg!  D.

    After you mentioned Doxazosin I checked it out affraid From here https://www.drugs.com/sfx/doxazosin-side-effects.html

    In addition to its needed effects, some unwanted effects may be caused by doxazosin. In the event that any of these side effects do occur, they may require medical attention.
    Severity: Moderate
    If any of the following side effects occur while taking doxazosin, check with your doctor or nurse as soon as possible:
    More common:
    Dizziness or lightheadedness
    Less common:
    Blurred vision
    confusion
    dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
    fainting (sudden)
    fast and pounding heartbeat
    irregular heartbeat
    shortness of breath
    sweating
    swelling of feet or lower legs
    Rare
    Painful or prolonged erection of the penis (called priapism), although extremely rare, must have immediate medical attention. If painful or prolonged erection occurs, call your doctor or go to an emergency room as soon as possible
    Incidence not known:
    Abdominal or stomach pain
    area rash
    black, tarry stools
    bleeding gums
    blood in urine or stools
    chest pain or discomfort
    chills
    clay-colored stools
    cough
    dark urine
    diarrhea
    difficulty breathing
    difficult, burning, or painful urination
    fever
    general tiredness and weakness
    headache, sudden and severe
    inability to speak
    itching
    lab results that show problems with liver
    light-colored stools
    loss of appetite
    noisy breathing
    pain or discomfort in arms, jaw, back or neck
    pinpoint red or purple spots on skin
    rash
    seizures
    slow or irregular heartbeat
    slurred speech
    sore throat
    sores, ulcers, or white spots on lips or in mouth
    swollen glands
    temporary blindness
    tightness in chest
    unpleasant breath odor
    unusual bleeding or bruising
    upper right abdominal pain
    vomiting
    vomiting of blood
    weakness in arm and/or leg on one side of the body, sudden and severe
    wheezing
    yellow eyes and skin
    Minor Side Effects
    Some of the side effects that can occur with doxazosin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
    More common:
    Headache
    lack or loss of strength
    unusual tiredness or weakness
    Less common:
    Acid or sour stomach
    back pain
    belching
    bladder pain
    cloudy urine
    difficulty in moving
    frequent urge to urinate
    heartburn
    indigestion
    joint pain
    lower back or side pain
    muscle aching, cramping, or weakness
    muscle pains or stiffness
    nausea
    nervousness, restlessness, unusual irritability
    runny nose
    sleepiness or drowsiness
    sneezing
    sore throat
    stomach discomfort, upset or pain
    swollen joints
    Incidence not known:
    Anxiety
    burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feeling
    change in frequency or urination
    dry mouth
    feeling of warmth
    frequent urination
    general feeling of discomfort or illness
    hair loss
    hives or welts
    hyperventilation
    increased urge to urinate during the night
    increased volume of pale dilute urine
    loss of appetite
    painful urination
    redness of skin
    redness of the face, neck, arms and occasionally upper chest
    shaking
    swelling of the breasts or breast soreness in both females and males
    thinning of hair
    trouble in holding or releasing urine
    trouble sleeping
    waking to urinate at night
    weight loss


    _________________
    Type two diabetic-low carb diet (50 carbs per day) and two 500mg Metformin pills per day. Apart from diagnosis HbA1c almost 12-all HbA1c results none diabetic. For over eight years my diabetes medication has not changed. My weight has remained stable, I have suffered no ill effects from my diet whatsoever. Every blood test has proved, I took the right road to my diabetic salvation. For almost seven years, I have asked medical professionals and naysayers, how do I maintain non diabetic BG levels on two Metformin other than low carb ? The silence has been deafening !
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    Derek
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    Re: Saturated fats and cardiovascular disease risk: A review

    Post by Derek on Sun Apr 09 2017, 14:06

    Thanks Eddie
    D.
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    Paul1976
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    Re: Saturated fats and cardiovascular disease risk: A review

    Post by Paul1976 on Sun Apr 09 2017, 16:42

    @Eddie wrote:
    @Derek wrote:They insist you take statins  then, as in my case, they give you a drug for bp that causes CVD and heart failure. Doxazosin, ALLHAT in 2000 said it was nbg!  D.

    After you mentioned Doxazosin I checked it out  affraid  From here https://www.drugs.com/sfx/doxazosin-side-effects.html

    In addition to its needed effects, some unwanted effects may be caused by doxazosin. In the event that any of these side effects do occur, they may require medical attention.
    Severity: Moderate
    If any of the following side effects occur while taking doxazosin, check with your doctor or nurse as soon as possible:
    More common:
    Dizziness or lightheadedness
    Less common:
    Blurred vision
    confusion
    dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
    fainting (sudden)
    fast and pounding heartbeat
    irregular heartbeat
    shortness of breath
    sweating
    swelling of feet or lower legs
    Rare
    Painful or prolonged erection of the penis (called priapism), although extremely rare, must have immediate medical attention. If painful or prolonged erection occurs, call your doctor or go to an emergency room as soon as possible
    Incidence not known:
    Abdominal or stomach pain
    area rash
    black, tarry stools
    bleeding gums
    blood in urine or stools
    chest pain or discomfort
    chills
    clay-colored stools
    cough
    dark urine
    diarrhea
    difficulty breathing
    difficult, burning, or painful urination
    fever
    general tiredness and weakness
    headache, sudden and severe
    inability to speak
    itching
    lab results that show problems with liver
    light-colored stools
    loss of appetite
    noisy breathing
    pain or discomfort in arms, jaw, back or neck
    pinpoint red or purple spots on skin
    rash
    seizures
    slow or irregular heartbeat
    slurred speech
    sore throat
    sores, ulcers, or white spots on lips or in mouth
    swollen glands
    temporary blindness
    tightness in chest
    unpleasant breath odor
    unusual bleeding or bruising
    upper right abdominal pain
    vomiting
    vomiting of blood
    weakness in arm and/or leg on one side of the body, sudden and severe
    wheezing
    yellow eyes and skin
    Minor Side Effects
    Some of the side effects that can occur with doxazosin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
    More common:
    Headache
    lack or loss of strength
    unusual tiredness or weakness
    Less common:
    Acid or sour stomach
    back pain
    belching
    bladder pain
    cloudy urine
    difficulty in moving
    frequent urge to urinate
    heartburn
    indigestion
    joint pain
    lower back or side pain
    muscle aching, cramping, or weakness
    muscle pains or stiffness
    nausea
    nervousness, restlessness, unusual irritability
    runny nose
    sleepiness or drowsiness
    sneezing
    sore throat
    stomach discomfort, upset or pain
    swollen joints
    Incidence not known:
    Anxiety
    burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feeling
    change in frequency or urination
    dry mouth
    feeling of warmth
    frequent urination
    general feeling of discomfort or illness
    hair loss
    hives or welts
    hyperventilation
    increased urge to urinate during the night
    increased volume of pale dilute urine
    loss of appetite
    painful urination
    redness of skin
    redness of the face, neck, arms and occasionally upper chest
    shaking
    swelling of the breasts or breast soreness in both females and males
    thinning of hair
    trouble in holding or releasing urine
    trouble sleeping
    waking to urinate at night
    weight loss

    But apart from that the drugs ok right? affraid


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    graham64
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    Re: Saturated fats and cardiovascular disease risk: A review

    Post by graham64 on Sun Apr 09 2017, 21:44

    There's a discussion forum covering Doxazosin on Patient UK

    https://patient.info/forums/discuss/browse/doxazosin-2703


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    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over nine years,

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
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    Re: Saturated fats and cardiovascular disease risk: A review

    Post by chris c on Mon Apr 10 2017, 01:00

    Judas F Priest!!!

    And they say low carb is dangerous.

    "It does actually state: Financial support and sponsorship Nil.

    Conflicts of interest There are no conflicts of interest."

    I know, I was just channelling the idiocy the likes of Carby McCarbface come out with when facts get in the way of their dogma.

    More

    http://www.medscape.com/viewarticle/875261

    http://www.medpagetoday.com/Cardiology/Prevention/63150

    The Truth Is Out There
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    graham64
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    Re: Saturated fats and cardiovascular disease risk: A review

    Post by graham64 on Mon Apr 10 2017, 22:10

    @chris c wrote:Judas F Priest!!!

    And they say low carb is dangerous.

    "It does actually state: Financial support and sponsorship Nil.

    Conflicts of interest There are no conflicts of interest."

    I know, I was just channelling the idiocy the likes of Carby McCarbface come out with when facts get in the way of their dogma.

    More

    http://www.medscape.com/viewarticle/875261

    http://www.medpagetoday.com/Cardiology/Prevention/63150

    The Truth Is Out There

    The final paragraph in that medscape article says it all


    The debate over the cholesterol hypothesis has continued because the results of cholesterol lowering interventions are inconsistent and contradictory. Nevertheless, clinical guidelines continue to emphasise the critical importance of cholesterol lowering to prevent CHD. Unfortunately, I believe this one-dimensional approach may have impeded the advancement of science and our search for other preventive strategies. The ACCELERATE trial may well herald our tipping point and a sea change in our approach to CHD prevention.


    _________________
    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over nine years,

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
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    chris c
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    Re: Saturated fats and cardiovascular disease risk: A review

    Post by chris c on Thu Apr 13 2017, 23:51

    Yes it's good when that sort of thing makes it into Medscape. Doctors might actually read it. Dieticians, not so much.
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    graham64
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    Re: Saturated fats and cardiovascular disease risk: A review

    Post by graham64 on Fri Apr 14 2017, 22:30

    @chris c wrote:Yes it's good when that sort of thing makes it into Medscape. Doctors might actually read it. Dieticians, not so much.

    Dietitians don't read at all they come off a production line pre programmed Laughing


    _________________
    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over nine years,

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
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    Re: Saturated fats and cardiovascular disease risk: A review

    Post by chris c on Sat Apr 15 2017, 23:14

    Sadly too many doctors and nurses also have been suckered into what they are told is "Evidence Based Medicine" which is actually more like marketing-based marketing.

    Yet another factor that has been ignored in the battle against cholesterol

    http://www.sciencedirect.com/science/article/pii/S0925443915000241

    Polyunsaturated fatty acids are susceptible to peroxidation and they yield various degradation products, including the main α,β-unsaturated hydroxyalkenal, 4-hydroxy-2,3-trans-nonenal (HNE) in oxidative stress. Due to its high reactivity, HNE interacts with various macromolecules of the cell, and this general toxicity clearly contributes to a wide variety of pathological conditions. In addition, growing evidence suggests a more specific function of HNE in electrophilic signaling as a second messenger of oxidative/electrophilic stress. It can induce antioxidant defense mechanisms to restrain its own production and to enhance the cellular protection against oxidative stress. Moreover, HNE-mediated signaling can largely influence the fate of the cell through modulating major cellular processes, such as autophagy, proliferation and apoptosis. This review focuses on the molecular mechanisms underlying the signaling and regulatory functions of HNE. The role of HNE in the pathophysiology of cancer, cardiovascular and neurodegenerative diseases is also discussed.

    James D Nicolantonio is always worth a read too

    http://openheart.bmj.com/content/1/1/e000032

    Here's Belinda Fettke among others

    http://www.nutritionforlife.healthcare/blog/lchf-our-approach-to-type-2-diabetes-management

    Now I wonder where this will lead

    https://www.sciencedaily.com/releases/2017/03/170327142820.htm

    One of these compounds, designed and optimized by TSRI scientists, significantly improves the health of diabetic animal models by reducing glucose levels in the blood, increasing insulin sensitivity and improving glucose balance.

    Hmmm, I did that through LCHF
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    Eddie
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    Re: Saturated fats and cardiovascular disease risk: A review

    Post by Eddie on Wed Apr 19 2017, 17:52

    John Yudkin was a man decades ahead of his time. He was one of the first scientists to warn of the dangers of sugar and highly refined carbohydrates. He became internationally famous with his book Pure, White and Deadly (published in English in 1972, with new editions in 1986 and 2012). I first heard of Yudkin when reading a Gary Taubes book an extract below re. Yudkin.

    “The George McGovern’s Senate Select Committee on Nutrition and Human Needs 1973.

    Peter Cleave testified to his belief that the problem extended to all refined carbohydrates. “I don’t hold the cholesterol view for a moment,” Cleave said, noting that mankind had been eating saturated fats for hundreds of thousands of years. “For a modern disease to be related to an old fashioned food is one of the most ludicrous things I have ever heard in my life,” Cleave said. “if anybody tells me that eating fat was the cause of coronary disease, I should look at them in amazement. But, when it comes to the dreadful sweet things that are served up … that is a very different proposition.” Yudkin blamed heart disease exclusively on sugar, and he was equally adamant that neither saturated fat nor cholesterol played a role. He explained how carbohydrates and specifically sugar in the diet could induce both diabetes and heart disease, through their effect on insulin secretion and the blood fats known as triglycerides. McGovern now struggled with the difficulty of getting some consensus on these matters.

    “Are you saying that you don’t think a high fat intake produces the high cholesterol count?” McGovern asked Yudkin. “Or are you even saying that a person with high cholesterol count is not in great danger?”

    “Well, I would like to exclude those rare people who have probably a genetic condition in which there is an extremely high cholesterol,” Yudkin responded. “If we are talking about the general population, I believe both those things that you say. I believe that decreasing the fat in the diet is not the best way of combating a high blood cholesterol …. I believe that the high blood cholesterol in itself has nothing whatever to do with heart disease.” “That is exactly opposite what my doctor told me,” said McGovern.

    Extract taken from the brilliant book ‘The Diet Delusion’ by Gary Taubes page 123 a must read for anyone with an interest in weight loss and controlling diabetes.


    _________________
    Type two diabetic-low carb diet (50 carbs per day) and two 500mg Metformin pills per day. Apart from diagnosis HbA1c almost 12-all HbA1c results none diabetic. For over eight years my diabetes medication has not changed. My weight has remained stable, I have suffered no ill effects from my diet whatsoever. Every blood test has proved, I took the right road to my diabetic salvation. For almost seven years, I have asked medical professionals and naysayers, how do I maintain non diabetic BG levels on two Metformin other than low carb ? The silence has been deafening !
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    Re: Saturated fats and cardiovascular disease risk: A review

    Post by chris c on Fri Apr 21 2017, 22:55

    Yes indeed. Then there were the likes of Joseph Kraft (died recently in his nineties, and interviewed by the incomparable Ivor Cummins on The Fat Emperor a few years back), Fred Kummerow, still going over 100 I believe, Mary Enig, Gerald Reaven (most of whose papers are still paywalled), Ron Krauss, past president of the AHA, and many many more whose work is now being picked up and developed by current researchers.

    Meanwhile

    http://www.heraldscotland.com/news/15227240.Government_food_adviser_in_row_over_paid_links_to_sweets_and_fizzy_drinks_companies/#comments-anchor

    https://patient.info/diabetes

    barf bag required

    http://us8.campaign-archive1.com/?u=63db7e07d57f8417546cdcec9&id=8819a57cad

    scroll down the the bottom of the page

    versus

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504183/pdf/nihms396311.pdf

    http://www.onlinejacc.org/content/43/5/731

      Current date/time is Tue Apr 25 2017, 23:12