The Low Carb Diabetic

Promoting a low carb high fat lifestyle for the safe control of diabetes. Eat whole fresh food, more drugs are not the answer.


Welcome to the Low Carb Diabetic forum,have you signed up yet? if not then sign up and join us in the low carb community today!

    Recovering Insulin-Producing Cells in Diabetics May Be Possible

    yoly
    yoly
    Member

    Status :
    Online
    Offline

    Posts : 641
    Join date : 2014-08-14

    Recovering Insulin-Producing Cells in Diabetics May Be Possible Empty Recovering Insulin-Producing Cells in Diabetics May Be Possible

    Post by yoly on Sun Feb 12 2017, 14:21

    Recovering Insulin-Producing Cells in Diabetics May Be Possible

    http://thediabeticnews.com/recovering-insulin-producing-cells-in-diabetics/

    February 11, 2017

    A new discovery may lead to the recovery of insulin-producing beta cells in people with type 1 diabetes.

    A Yale-led research team identified how insulin-producing cells that are typically destroyed in type 1 diabetes can change in order to survive immune attack.

    The finding may lead to strategies for recovering these cells in diabetic patients, said the researchers.
    Researchers Testing Beta Cells

    Researchers identified a subpopulation of beta cells that resists immune attack.

    The study was published on Feb. 9 in Cell Metabolism.

    In patients with type 1 diabetes, an autoimmune disease, the immune system destroys beta cells — the cells that produce insulin in the pancreas. But some beta cells survive in diabetic patients even years after the onset of disease.

    A team of researchers at Yale and the Broad Institute of MIT and Harvard studied the changes in beta cells that occur during immune attack that may lead to their persistence in both mouse models of type 1 diabetes and in human cells in culture.

    The researchers identified a subpopulation of beta cells that resists immune attack. “During the development of diabetes, there are changes in beta cells so you end up with two populations of beta cells,” said professor of immunobiology and senior author Kevan Herold, M.D. “One population is killed by the immune response. The other population seems to acquire features that render it less susceptible to killing.”

    This subpopulation survives by using a “duck and cover” approach, Herold noted. The cells express molecules that inhibit the immune response. They also acquire “stemness,” or a stem-cell-like ability to revert to an earlier stage of development in which they can persist and proliferate despite immune attack.

    The discovery will lead to further investigation of strategies that could benefit diabetic patients. “The next question is, can we recover these cells so that there is insulin production in someone in type 1 diabetes?” said Herold.

    He and his colleagues plan to test drugs to see if they can modify the beta cell subpopulation and turn it into insulin-producing cells.

    Other authors are Jinxiu Rui, Songyan Deng, Arnon Arazi, Ana Luisa Perdigoto, and Zongzhi Liu.

    The study was supported by National Institute of Health grants, grants from the Juvenile Diabetes Research Foundation and Yale CTSA, and a gift from the Howalt family.

    Source: Yale University
    Journal: Cell Metabolism
    Citation: Cell Metabolism, DOI: 10.1016/j.cmet.2017.01.005
    chris c
    chris c
    Member

    Status :
    Online
    Offline

    Posts : 4520
    Join date : 2015-07-26

    Recovering Insulin-Producing Cells in Diabetics May Be Possible Empty Re: Recovering Insulin-Producing Cells in Diabetics May Be Possible

    Post by chris c on Mon Feb 13 2017, 23:09

    A Type 1 I knew, now long dead, reckoned he had spent his life reading about "cures" for diabetes which were "only five or ten years away" for most of his life.

    Nevertheless I think Joslin found that some of their medallists - who had had Type 1 for decades - still had measurable (although very low) insulin production. This may explain how. Even that appeared to be protective, probably because it was generated in close proximity to the alpha cells and controlled glucagon, which ties in with Roger Unger.

      Current date/time is Sun Aug 18 2019, 21:03