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    Research by Yale-NUS College identifies treatment of metabolic dysfunction as a potential therapy for Alzheimer’s disease

    yoly
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    Research by Yale-NUS College identifies treatment of metabolic dysfunction as a potential therapy for Alzheimer’s disease Empty Research by Yale-NUS College identifies treatment of metabolic dysfunction as a potential therapy for Alzheimer’s disease

    Post by yoly on Fri Oct 18 2019, 20:32

    Research by Yale-NUS College identifies treatment of metabolic dysfunction as a potential therapy for Alzheimer’s disease

    https://www.yale-nus.edu.sg/newsroom/research-by-yale-nus-college-identifies-treatment-of-metabolic-dysfunction-as-a-potential-therapy-for-alzheimers-disease/


    17 October 2019

    Researchers discover that metabolic dysfunction and not protein accumulation is a key cause of Alzheimer’s disease. A common anti-diabetes drug was identified as a potential treatment

    A team of researchers led by Yale-NUS College has found evidence that metabolic dysfunction is a primary cause of Alzheimer’s disease.

    Alzheimer’s disease is the most common neurodegenerative disease affecting the elderly worldwide, as well as one of the most common causes of dementia. In Singapore, one in 10 people aged 60 or above is believed to suffer from dementia. After more than twenty years of research effort worldwide, scientists are still unable to identify the exact causes of Alzheimer’s and no proven treatment is available. Two competing theories are currently proposed to explain the cause of Alzheimer’s: the first is focused on the accumulation of a specific protein, called amyloid-beta protein, in the brain as the primary cause; whilst a second and more recent theory proposes that metabolic dysfunction, specifically a dysfunction of the cell’s energy-producing machinery called mitochondria is responsible.

    In a new study published in the scientific journal eLife, a team led by Assistant Professor of Science (Biochemistry) Jan Gruber from Yale-NUS College discovered that metabolic defects occur well before any significant increase in the amount of amyloid-beta protein could be detected. The research used a tiny worm called Caenorhabditis elegans to identify these changes because it shares many similarities at the molecular level with human cells. A further breakthrough came when the team found that treatment of the worms with a common anti-diabetes drug called Metformin reversed these metabolic defects and normalised the worms’ healthspan and lifespan.

    “Current trials of Alzheimer’s drugs targeting proteins have failed despite billions of dollars being invested. Based on the emerging strong links between mitochondrial dysfunction and Alzheimer’s pathology, it might be better to adopt a preventative strategy by targeting metabolic defects, especially mitochondrial defects, directly and early, well before protein aggregates are even present,” said Assistant Professor Gruber.

    He further explained that metabolic and mitochondrial dysfunctions should be viewed as fundamental features of ageing in general and that age-dependent diseases, including Alzheimer’s, should therefore be viewed as manifestations of ageing. Hence, it may be easier to prevent or treat age-dependent diseases by targeting the mechanisms of ageing rather than treating individual diseases after symptoms occur.

    The experiments for this research were primarily conducted at Yale-NUS College in a purpose-built 7,000 square-foot research laboratory. This facility was opened in 2018 to support advanced research in molecular biology. The laboratory has built strong partnerships with other laboratories at the National University of Singapore, Duke-NUS Medical School, the National University Health System Centre for Healthy Ageing, and the University of Buffalo in the USA.
    Jan1
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    Research by Yale-NUS College identifies treatment of metabolic dysfunction as a potential therapy for Alzheimer’s disease Empty Re: Research by Yale-NUS College identifies treatment of metabolic dysfunction as a potential therapy for Alzheimer’s disease

    Post by Jan1 on Sun Oct 20 2019, 23:26

    Thanks for posting this Yoly.
    Interesting to read that Metformin is once again mentioned.

    I just put the word Metformin into this Forums search bar and it features in quite a few posts!
    Lots to read Smile

    This is another interesting article to read (well I thought so) and links in to the ageing theory

    Metformin: The Key to Longer Life?
    https://onedrop.today/blogs/blog/metformin-key-longer-life

    All the best Jan

      Current date/time is Thu Nov 14 2019, 07:03