The Low Carb Diabetic

Promoting a low carb high fat lifestyle for the safe control of diabetes. Eat whole fresh food, more drugs are not the answer.


Welcome to the Low Carb Diabetic forum,have you signed up yet? if not then sign up and join us in the low carb community today!

    Fasting -β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4

    Share
    avatar
    yoly
    Member

    Status :
    Online
    Offline

    Posts : 592
    Join date : 2014-08-14

    Fasting -β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4

    Post by yoly on Tue Sep 11 2018, 19:29

    (Ketone produced when fasting and LCHF protect arteries and is anti-aging)

    β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4

    https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30605-1


    Highlights

    β-hydroxybutyrate prevents the vascular cell senescence
    β-hydroxybutyrate upregulates Oct4 expression via interacting with hnRNP A1
    Oct4-mediated quiescence is able to attenuate hallmarks of senescence
    Circulating β-hydroxybutyrate alleviates the senescence of mouse aorta

    Summary
    β-hydroxybutyrate (β-HB) elevation during fasting or caloric restriction is believed to induce anti-aging effects and alleviate aging-related neurodegeneration. However, whether β-HB alters the senescence pathway in vascular cells remains unknown. Here we report that β-HB promotes vascular cell quiescence, which significantly inhibits both stress-induced premature senescence and replicative senescence through p53-independent mechanisms. Further, we identify heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) as a direct binding target of β-HB. β-HB binding to hnRNP A1 markedly enhances hnRNP A1 binding with Octamer-binding transcriptional factor (Oct) 4 mRNA, which stabilizes Oct4 mRNA and Oct4 expression. Oct4 increases Lamin B1, a key factor against DNA damage-induced senescence. Finally, fasting and intraperitoneal injection of β-HB upregulate Oct4 and Lamin B1 in both vascular smooth muscle and endothelial cells in mice in vivo. We conclude that β-HB exerts anti-aging effects in vascular cells by upregulating an hnRNP A1-induced Oct4-mediated Lamin B1 pathway.
    avatar
    chris c
    Member

    Status :
    Online
    Offline

    Posts : 4439
    Join date : 2015-07-26

    Re: Fasting -β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4

    Post by chris c on Fri Sep 14 2018, 22:47

    Gosh you'd almost think we evolved not to be laden with glucose at all times. Perhaps someone should tell the dieticians.

      Current date/time is Tue Nov 13 2018, 18:10