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    Ohio State Scientists Identify Hormone Link Between Diabetes and Hypertension

    yoly
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    Post by yoly on Thu Sep 06 2018, 10:44

    Ohio State Scientists Identify Hormone Link Between Diabetes and Hypertension

    https://wexnermedical.osu.edu/mediaroom/pressreleaselisting/hormone-link-between-diabetes-and-hypertension

    COLUMBUS, Ohio – Physician researchers with The Ohio State University College of Medicine at the Wexner Medical Center say increased levels of the hormone aldosterone, already associated with hypertension, can play a significant role in the development of diabetes, particularly among certain racial groups.

    “This research is an important step toward finding new ways to prevent a major chronic disease,” said Dr. K. Craig Kent, dean of the College of Medicine. “This shows how our diabetes and metabolism scientists are focused on creating a world without diabetes.”

    Results of this study were published online today by the Journal of the American Heart Association.

    Joshua J Joseph MD“Aldosterone is produced by the adrenal gland. We’ve known for some time that it increases blood pressure. We’ve recently learned it also increases insulin resistance in muscle and impairs insulin secretion from the pancreas. Both actions increase a person’s risk of developing type 2 diabetes, but the question was – how much,” said Dr. Joshua J. Joseph, lead investigator and an endocrinologist at Ohio State Wexner Medical Center.

    Joseph and his team followed 1,600 people across diverse populations for 10 years as part of the Multi-Ethnic Study of Atherosclerosis. They found, overall, the risk of developing type 2 diabetes more than doubled for people who had higher levels of aldosterone, compared to participants with lower levels of the hormone. In certain ethnicities, the effect was even greater. African Americans with high aldosterone levels have almost a three-fold increased risk. Chinese Americans with high aldosterone are 10 times more likely to develop diabetes.

    “I looked into this as a promise to my father. He had high levels of aldosterone that contributed to his hypertension, and he thought it also might be linked to his diabetes. As my career progressed, I had the opportunity to research it, and we did find a link to diabetes,” Joseph said.

    One question that remains is why there are wide differences in risk among various ethnic groups. Joseph said it could be genetics or differences in salt sensitivity or something else, and it needs further study.

    Just over 30 million Americans have diabetes and nearly a fourth of them don’t know it, according to the Centers for Disease Control and Prevention. Another one in three Americans has prediabetes. Despite current preventive efforts, the numbers continue to climb among various racial/ethnic groups.

    Next, Joseph will lead a federally funded clinical trial at Ohio State Wexner Medical Center to evaluate the role of aldosterone in glucose metabolism. African American participants who have prediabetes will take medication to lower their aldosterone levels. Researchers will study the impact on blood glucose and insulin in those individuals.

    “We know there’s a relationship between aldosterone and type 2 diabetes. Now we need to determine thresholds that will guide clinical care and the best medication for treatment,” Joseph said.

    He expects to start enrolling patients in that trial later this year.
    chris c
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    Post by chris c on Thu Sep 06 2018, 23:21

    Fascinating. I have to wonder which way the link works, hyperinsulinemia affects BP through the renin-angiotensin system via the kidneys, does it also cause the high aldosterone?
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    Post by Long birder on Sat Sep 15 2018, 15:24

    Jerome Conn knew this and published on it over 50 years ago.  High aldosterone stops the islet cells producing insulin. A very high percentage of Conn's patients with an aldosterone producing adenoma had/has T2D.
    Triggering the RAS in healthy patients is not a wise course because it increases aldosterone production.

    Aldosterone is a survival hormone, so that the body retains a proper fluid and electrolyte balance during times of starvation and depletion of sodium etc.

    If you don't have Conn's like I do it is unwise to cut right down on sodium.
    Unlike myself I can't get rid of sodium and am super medicated to stop aldosterone damaging every organ system in my body by blocking any aldosterone receptors.
    It is just a pity it took nearly thirty years for medics to find out what was knackering my heart and causing htn. Caught in time removing the tumour is one of few way to cure serious htn.

    Derek
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    Post by chris c on Tue Sep 18 2018, 22:54

    Interesting how it all ties in together.

    I had to laugh at this though

    “This research is an important step toward finding new ways to prevent a major chronic disease,” said Dr. K. Craig Kent, dean of the College of Medicine. “This shows how our diabetes and metabolism scientists are focused on creating a world without diabetes.”

    They are probably trying to develop a pill so people can still eat high carb diets
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    Post by Long birder on Wed Sep 19 2018, 15:02

    There is no money for big pharma in cutting carbs!

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