The Low Carb Diabetic

Promoting a low carb high fat lifestyle for the safe control of diabetes. Eat whole fresh food, more drugs are not the answer.


Welcome to the Low Carb Diabetic forum,have you signed up yet? if not then sign up and join us in the low carb community today!

    Records point to drug-drug interaction

    Share
    avatar
    graham64
    Member

    Status :
    Online
    Offline

    Male Posts : 3390
    Join date : 2014-08-10
    Location : Lancs

    Records point to drug-drug interaction

    Post by graham64 on Wed May 09 2018, 21:34

    Daptomycin is an antibiotic used to treat serious bacterial infections. Statins are drugs prescribed on a long-term basis to prevent or reduce cardiovascular disease by lowering LDL-cholesterol.

    In a retrospective study, researchers at Vanderbilt University Medical Center found that VUMC patients who continued taking a statin while taking daptomycin had 2.6 times greater risk of developing myopathy (muscle weakness) and 4.67 times greater risk of a more severe form of muscle damage called rhabdomyolysis.

    "This is the first study to provide strong evidence supporting this association," reported Ryan Dare, MD, MS, and co-authors in the journal Clinical Infectious Diseases. Echoing the maker of daptomycin, the study authors recommend that doctors consider withholding statins during daptomycin therapy.

    Among patients on statins seen at VUMC between 2004-2015, the researchers found 128 cases of daptomycin-associated myopathy, including 25 cases of rhabdomyolysis; they matched these patients to myopathy-free controls, adjusting their analyses to account for a range of risk factors.

    https://medicalxpress.com/news/2018-05-drug-drug-interaction.html

    Study here: https://www.ncbi.nlm.nih.gov/pubmed/29668884


    _________________
    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over ten years

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
    avatar
    chris c
    Member

    Status :
    Online
    Offline

    Posts : 3873
    Join date : 2015-07-26

    Re: Records point to drug-drug interaction

    Post by chris c on Thu May 10 2018, 21:46

    http://sci-hub.hk/10.1093/cid/ciy287

    I'll read it later to see if the mechanism has been identified

      Current date/time is Fri May 25 2018, 23:17