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    New leads on treating dementia and Alzheimer’s

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    yoly
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    New leads on treating dementia and Alzheimer’s

    Post by yoly on Thu May 03 2018, 13:04

    New leads on treating dementia and Alzheimer’s

    https://www.newsmaker.com.au/news/372856/new-leads-on-treating-dementia-and-alzheimers

    Thursday, May 3rd, 2018

    A new study by scientists in Australia and the US provides an explanation for why clinical trials of drugs targeting proteins in the brain that were thought to cause dementia and Alzheimer’s have failed. The study has opened the way for potential new treatments with existing drugs.



    Published online in the journal Human Molecular Genetics, the researchers assembled evidence from a wide range of human studies and animal models of dementia-related diseases to show that inflammation is a major cause, not just a consequence.



    They show that many genes linked with dementia regulate our susceptibility and response to inflammatory damage.



    “For decades, scientists have thought that dementia and Alzheimer’s Disease are caused by protein aggregates forming in the brain. But recent clinical trials of drugs that reduce the aggregates have failed,” says project leader Professor Robert Richards, from the University of Adelaide’s School of Biological Sciences. He is working in collaboration with the University’s Adelaide Medical School and the National Institutes of Health, in the US.



    Inflammation has long been known to increase as dementia-related diseases progress, but only now is it identified as the cause. Previously it was thought to act simply to clean up tissue damage caused by the protein aggregates.



    “We know that inflammation has different phases – early on it can be protective against a threat by actively degrading it, but if the threat is not removed, then persistent inflammation actually causes cell death,” says Professor Richards.



    The new work turns previous thinking around. The genetic linkages imply that the inflammation comes first – and the tissue damage second.



    “Many genes linked with dementia operate at the level of controlling cellular inflammation. Both internal and external triggers interact with these genes to play a part. Inflammation is the point through which many triggers converge,” says Professor Richards.



    He likens the brain inflammation to a virus infection. “Inflammation is a very effective defence against foreign agents like viruses. But as we get older and accumulate mutations, our cells can make proteins and DNA products that mimic viruses, and these build up in the system,” he says.



    “Normally, our cells bar-code their own products to tell them apart from foreign agents. When these bar-codes aren’t in place, our cells can’t properly distinguish ‘self’ and ‘non-self’ trigger molecules. The result is inflammation that escalates and spreads – hence the term autoinflammatory disease.”



    Certain types of gene mutation cause these systems to fail earlier or more often, and can increase as we age – possibly accounting for age-related increased risk of developing dementia. The good news is that by reducing some elements of inflammation, it may be possible to reduce dementia symptoms.



    “With this new understanding of the disease, we now need to test existing anti-inflammatory drugs for their effectiveness in treating dementia,” he says. ##
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    yoly
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    Re: New leads on treating dementia and Alzheimer’s

    Post by yoly on Thu May 03 2018, 13:05

    Neurodegenerative diseases have genetic hallmarks of autoinflammatory disease

    https://academic.oup.com/hmg/advance-article-abstract/doi/10.1093/hmg/ddy139/4976601?redirectedFrom=fulltext

    Abstract

    The notion that one common pathogenic pathway could account for the various clinically distinguishable, typically late-onset neurodegenerative diseases might appear unlikely given the plethora of diverse primary causes of neurodegeneration. On the contrary, an autoinflammatory pathogenic mechanism allows diverse genetic and environmental factors to converge into a common chain of causality. Inflammation has long been known to correlate with neurodegeneration. Until recently this relationship was seen as one of consequence rather than cause – with inflammatory cells and events acting to “clean up the mess” after neurological injury. This explanation is demonstrably inadequate and it is now clear that inflammation is at the very least, rate-limiting for neurodegeneration (and more likely, a principal underlying cause in most if not all neurodegenerative diseases), protective in its initial acute phase, but pernicious in its latter chronic phase.
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    Jan1
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    Re: New leads on treating dementia and Alzheimer’s

    Post by Jan1 on Thu May 03 2018, 19:31

    Many thanks for these posts Yoly ...

    "The good news is that by reducing some elements of inflammation, it may be possible to reduce dementia symptoms."

    I see that they are also talking about "testing existing anti-inflammatory drugs for their effectiveness in treating dementia" ... which could and may help sufferers in the future.

    But as with so many other diseases I do think diet and lifestyle can and does help ...

    All the best Jan
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    yoly
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    Re: New leads on treating dementia and Alzheimer’s

    Post by yoly on Fri May 04 2018, 11:42

    Jan that is the default mode of every research find a pill so that we can partner with some pharmaceutical company so we can all make money. But as you point out there are many way we can help the body without a pill.
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    chris c
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    Re: New leads on treating dementia and Alzheimer’s

    Post by chris c on Fri May 04 2018, 20:59

    I read something recently about depression also being seen as a consequence of inflammation.

    There's a world of difference between acute inflammation as a beneficial response to an infection (for example) and chronic inflammation driven by many avoidable factors including but not limited to excess glucose, excess insulin and excess Omega 6 seed oils, not to mention inflammatory substances put out by body fat.

    If meat hasn't yet been blamed for causing Alzheimers, it will be.

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    Re: New leads on treating dementia and Alzheimer’s

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