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    Higher Prevalence of “Low T3 Syndrome” in Patients With Chronic Fatigue Syndrome

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    yoly
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    Higher Prevalence of “Low T3 Syndrome” in Patients With Chronic Fatigue Syndrome

    Post by yoly on Wed Mar 21 2018, 12:44

    Higher Prevalence of “Low T3 Syndrome” in Patients With Chronic Fatigue Syndrome
    (complete article in link https://www.frontiersin.org/articles/10.3389/fendo.2018.00097/full )
    Original Research ARTICLE
    Front. Endocrinol., 20 March 2018 | https://doi.org/10.3389/fendo.2018.00097

    Chronic fatigue syndrome (CFS) is a heterogeneous disease with unknown cause(s). CFS symptoms resemble a hypothyroid state, possibly secondary to chronic (low-grade) (metabolic) inflammation. We studied 98 CFS patients (21–69 years, 21 males) and 99 age- and sex-matched controls (19–65 years, 23 males). We measured parameters of thyroid function, (metabolic) inflammation, gut wall integrity and nutrients influencing thyroid function and/or inflammation. Most remarkably, CFS patients exhibited similar thyrotropin, but lower free triiodothyronine (FT3) (difference of medians 0.1%), total thyroxine (TT4) (11.9%), total triiodothyronine (TT3) (12.5%), %TT3 (4.7%), sum activity of deiodinases (14.4%), secretory capacity of the thyroid gland (14.9%), 24-h urinary iodine (27.6%), and higher % reverse T3 (rT3) (13.3%). FT3 below the reference range, consistent with the “low T3 syndrome,” was found in 16/98 CFS patients vs. 7/99 controls (OR 2.56; 95% confidence interval = 1.00–6.54). Most observations persisted in two sensitivity analyses with more stringent cutoff values for body mass index, high-sensitive C-reactive protein (hsCRP), and WBC. We found possible evidence of (chronic) low-grade metabolic inflammation (ferritin and HDL-C). FT3, TT3, TT4, and rT3 correlated positively with hsCRP in CFS patients and all subjects. TT3 and TT4 were positively related to hsCRP in controls. Low circulating T3 and the apparent shift from T3 to rT3 may reflect more severely depressed tissue T3 levels. The present findings might be in line with recent metabolomic studies pointing at a hypometabolic state. They resemble a mild form of “non-thyroidal illness syndrome” and “low T3 syndrome” experienced by a subgroup of hypothyroid patients receiving T4 monotherapy. Our study needs confirmation and extension by others. If confirmed, trials with, e.g., T3 and iodide supplements might be indicated.
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    chris c
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    Re: Higher Prevalence of “Low T3 Syndrome” in Patients With Chronic Fatigue Syndrome

    Post by chris c on Wed Mar 21 2018, 23:54

    Very interesting! My money is on the culprit being damaged mitochondria. I previously also suspected neurotransmitters or damaged neuroreceptors but this makes some sense.

    My thyroid went the other way but when overtreated I get a bunch of different symptoms, mainly an overall slowing of pretty much everything. Hypothyroid is yet another thing which purely coincidentally of course started to become way more common with the adoption of high carb low fat diets and which has been blamed on low carb. ME/CFS too, along with Alzheimers and now Parkinsons has also been associated.

      Current date/time is Sun Jul 22 2018, 03:35