The Low Carb Diabetic

Promoting a low carb high fat lifestyle for the safe control of diabetes. Eat whole fresh food, more drugs are not the answer.


Welcome to the Low Carb Diabetic forum,have you signed up yet? if not then sign up and join us in the low carb community today!

    Minoxidil improves vascular compliance, restores cerebral blood flow and alters extracellular matrix gene expression in a model of chronic vascular stiffness

    Share
    avatar
    yoly
    Member

    Status :
    Online
    Offline

    Posts : 584
    Join date : 2014-08-14

    Minoxidil improves vascular compliance, restores cerebral blood flow and alters extracellular matrix gene expression in a model of chronic vascular stiffness

    Post by yoly on Wed Mar 21 2018, 12:42

    (Balding medication)
    Minoxidil improves vascular compliance, restores cerebral blood flow and alters extracellular matrix gene expression in a model of chronic vascular stiffness
    https://www.physiology.org/doi/10.1152/ajpheart.00683.2017
    Abstract

    Increased vascular stiffness correlates with higher risk of cardiovascular complications in aging adults. Elastin insufficiency, as observed in patients with Williams-Beuren syndrome or with familial supravalvular aortic stenosis, also increases vascular stiffness and leads to arterial narrowing. We used Eln+/- mice to test the hypothesis that pathologically increased vascular stiffness with concomitant arterial narrowing leads to decreased blood flow to end organs such as the brain. We also hypothesized that drugs which remodel arteries and increase lumen diameter would improve flow. To test these hypotheses, we compared carotid blood flow using ultrasound and cerebral blood flow using MRI-based arterial spin labeling in WT and Eln+/- mice. We then studied how minoxidil, a KATP channel opener and vasodilator, affects vessel mechanics, blood flow and gene expression. Both carotid and cerebral blood flows were lower in Eln+/- than in WT mice. Treatment of Eln+/- mice with minoxidil lowered blood pressure and reduced functional arterial stiffness to WT levels. Minoxidil also improved arterial diameter and restored carotid and cerebral blood flows in Eln+/- mice. Beneficial effects persisted for weeks after drug removal. RNA-Seq analysis revealed differential expression of 127 extracellular matrix-related genes among the treatment groups. These results indicate that elastin insufficiency impairs end organ perfusion, which may contribute to increased cardiovascular risk. Minoxidil, despite lowering blood pressure, improves end organ perfusion. Changes in matrix gene expression and persistence of treatment effects after drug withdrawal suggest arterial remodeling. Such remodeling may benefit patients with genetic or age-dependent elastin insufficiency.
    avatar
    chris c
    Member

    Status :
    Online
    Offline

    Posts : 4373
    Join date : 2015-07-26

    Re: Minoxidil improves vascular compliance, restores cerebral blood flow and alters extracellular matrix gene expression in a model of chronic vascular stiffness

    Post by chris c on Wed Mar 21 2018, 23:45

    Then there's Viagra. Hugely beneficial compared to anything statins can do.
    avatar
    chris c
    Member

    Status :
    Online
    Offline

    Posts : 4373
    Join date : 2015-07-26

    Re: Minoxidil improves vascular compliance, restores cerebral blood flow and alters extracellular matrix gene expression in a model of chronic vascular stiffness

    Post by chris c on Wed Mar 21 2018, 23:46

    Oh that's interesting, I just had to prove I am not a spammer, presumably because I mentioned the V word.

    Sponsored content

    Re: Minoxidil improves vascular compliance, restores cerebral blood flow and alters extracellular matrix gene expression in a model of chronic vascular stiffness

    Post by Sponsored content


      Current date/time is Sun Oct 21 2018, 13:49