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    More Statin news

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    graham64
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    More Statin news

    Post by graham64 on Tue Mar 20 2018, 22:24

    Statins and hayfever pills could be driving antibiotic resistance, warn scientists 

    https://www.telegraph.co.uk/science/2018/03/19/statins-hayfever-pills-could-driving-antibiotic-resistance-warn/

    Statin Use May Accelerate Disease Onset in Rheumatoid Arthritis

    https://www.rheumatologyadvisor.com/rheumatoid-arthritis-advisor/rheumatoid-arthritis-risk-patterns-statin-use/article/751113/

    But don't forget folks the benefits of statins far outweigh the risks  Rolling Eyes


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    Re: More Statin news

    Post by yoly on Wed Mar 21 2018, 10:03

    How poisoning your liver to stop producing cholesterol good be a good thing?
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    Re: More Statin news

    Post by yoly on Wed Mar 21 2018, 12:51

    Statins were develop copying a mycotoxin produced by a fungus and now is synthetically produced in the lab. Some have the theory that diabetes is caused by fungus and mycotoxins from fungus, statins worsen blood sugar control so who knows.
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    Re: More Statin news

    Post by chris c on Wed Mar 21 2018, 22:46

    Shutting down the entire mevalonate pathway just to lower LDL turns out not to have been such a good plan after all.

    Meanwhile

    Clinical and pathophysiological evidence
    supporting the safety of extremely low LDL
    levels—The zero-LDL hypothesis

    http://sci-hub.hk/10.1016/j.jacl.2017.12.018

    I haven't read this yet but I suspect Extreme Marketing
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    Jan1
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    Re: More Statin news

    Post by Jan1 on Thu Mar 22 2018, 11:00

    Dr Malhotra mentioned statins ...

    "You can't drug people into being healthy!

    Cardiologist Dr Malhotra takes on the CEO of Pharma giant Astra Zeneca at the prestigious Cambridge Union. "

    Well worth watching the video - see here
    https://thelowcarbdiabetic.blogspot.co.uk/2018/03/you-cant-drug-people-into-being-healthy.html

    All the best Jan
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    Re: More Statin news

    Post by graham64 on Thu Mar 22 2018, 22:23

    @chris c wrote:Shutting down the entire mevalonate pathway just to lower LDL turns out not to have been such a good plan after all.

    Meanwhile

    Clinical and pathophysiological evidence
    supporting the safety of extremely low LDL
    levels—The zero-LDL hypothesis

    http://sci-hub.hk/10.1016/j.jacl.2017.12.018

    I haven't read this yet but I suspect Extreme Marketing

    Just had a look at the conflicts of interest and pharma are well represented 

    Luis Masana receives lecture and advisory fees from Amgen, Sanofi, MSD. N#uria Plana receives lecture fees from Sanofi, Amgen, MSD, Alexion, Ferre, Esteve. aiana Ibarretxe receives lecture fees from Sanofi, Rubio, Ferre,
    MSD, Esteve. The other authors have no conflict of interest to declare


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    Re: More Statin news

    Post by graham64 on Thu Mar 22 2018, 22:37

    @Jan1 wrote:Dr Malhotra mentioned statins ...

    "You can't drug people into being healthy!

    Cardiologist Dr Malhotra takes on the CEO of Pharma giant Astra Zeneca at the prestigious Cambridge Union. "

    Well worth watching the video - see here
    https://thelowcarbdiabetic.blogspot.co.uk/2018/03/you-cant-drug-people-into-being-healthy.html

    All the best Jan

    Yes overmedication is rife especially in the elderly and drugs come side effects


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    Re: More Statin news

    Post by yoly on Fri Mar 23 2018, 09:50

    Since people are opening their eyes at how poorly they work. They are now opening a new front lowering LDL to fight cancer, the other big scare.
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    Re: More Statin news

    Post by chris c on Fri Mar 23 2018, 22:10

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    Re: More Statin news

    Post by graham64 on Mon Apr 02 2018, 22:29

    Medicine to control cholesterol lands 80-year-old in Mumbai hospital with kidney failure

    Within a month of taking the medication, Dinoo Irani stopped passing urine; she spent close to a month in Bhatia hospital

    https://www.hindustantimes.com/mumbai-news/medicine-to-control-cholesterol-lands-80-year-old-in-mumbai-hospital-with-kidney-failure/story-NVVPTVLLcJ6UUDNvx1Xc7L.html


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    Re: More Statin news

    Post by chris c on Tue Apr 03 2018, 23:34

    "The patient died, but she died with low cholesterol, which is good."

    Good grief, isn't there an age cutoff of 75 even in the manufacturers' literature?
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    Re: More Statin news

    Post by graham64 on Thu Apr 05 2018, 22:19

    Amyotrophic Lateral Sclerosis Associated with Statin Use: A Disproportionality Analysis of the FDA’s Adverse Event Reporting System

    https://link.springer.com/article/10.1007%2Fs40264-017-0620-4


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    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes

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    Re: More Statin news

    Post by Long birder on Fri Apr 06 2018, 16:35

    @graham64 wrote:Amyotrophic Lateral Sclerosis Associated with Statin Use: A Disproportionality Analysis of the FDA’s Adverse Event Reporting System

    https://link.springer.com/article/10.1007%2Fs40264-017-0620-4
    Hi Graham,
    If what I read is correct that is a b.a. disease like motor neurone disease!
    Low odds I suppose but not nice!
    D.
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    Re: More Statin news

    Post by chris c on Fri Apr 06 2018, 21:45

    Wow, those RORs are HUGE. Scary stuff considering the massive and ongoing increases in Alzheimers and other conditions resulting in age-related degeneration.

    I wonder if they are working on a drug to counter ALS.
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    Re: More Statin news

    Post by graham64 on Mon Apr 09 2018, 21:22

    Malcolm Kendrick has a post about the study 

    Statins and Amyotrophic Lateral Sclerosis

    https://drmalcolmkendrick.org/2018/04/09/statins-and-amyotrophic-lateral-sclerosis/


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    Re: More Statin news

    Post by yoly on Tue Apr 10 2018, 11:38

    Really scary; I don't know how people can believe that messing with something the body produce and have so many uses in the body, at the root of is production can be of benefit. The power of marketing and mass manipulation is tremendous.
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    Re: More Statin news

    Post by graham64 on Tue Apr 10 2018, 22:24

    @yoly wrote:Really scary; I don't know how people can believe that messing with something the body produce and have so many uses in the body, at the root of is production can be of benefit. The power of marketing and mass manipulation is tremendous.

    Yes it is scary and they still say the benefits of statins outweigh the risks try telling that to someone who's now suffering MND because of them, this study and others that have reported serious life changing problems with statin use would suggest the risks far outweigh any so called benefits.


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    Re: More Statin news

    Post by chris c on Wed Apr 11 2018, 23:13

    When you die of MND you didn't die of heart disease. QED.
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    Re: More Statin news

    Post by graham64 on Thu Apr 12 2018, 22:58

    The influence of big pharma is plain to see in these ADA guidelines

    ADA Updates Guidelines for Cardiovascular Risk Management in Diabetes

    In patients with diabetes and ASCVD who have low-density lipoprotein cholesterol ≥70 mg/dL and who are taking a maximally tolerated statin dose, additional low-density lipoprotein cholesterol-lowering treatments are recommended, including ezetimibe or a PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor (Grade A recommendation).

    Dr Chamberlain reports other support from Novo Nordisk, Sanofi Aventis, Janssen, and Merck outside the submitted work. Dr Johnson reports personal fees from Novo Nordisk, Medtronic, and Sanofi outside the submitted work. Dr Rhinehart reports employment with and stock ownership in Glytec. Dr Shubrook reports personal fees from Novo Nordisk, Lilly Diabetes, and Intarcia outside the submitted work.

    https://www.thecardiologyadvisor.com/metabolic/cardiovascular-risk-management-in-diabetes-guidelines/article/757545/


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    Re: More Statin news

    Post by chris c on Fri Apr 13 2018, 22:05

    Or you could just read Dave Feldman's blog

    http://cholesterolcode.com/

    to see just how variable LDL can be, yet one high number gets you medicated for life
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    Re: More Statin news

    Post by graham64 on Tue May 15 2018, 22:24

    Is statin use a waste of time and money?

    Transparency is lacking around efficacy of widely used cholesterol-lowering drug

    https://www.irishtimes.com/life-and-style/health-family/is-statin-use-a-waste-of-time-and-money-1.3486799


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    Proving the LowCarb sceptics wrong for over ten years

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    Re: More Statin news

    Post by chris c on Tue May 15 2018, 22:41

    Strange how they don't look so good in non-manufacturer-sponsored trials.
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    Re: More Statin news

    Post by chris c on Thu May 17 2018, 22:41

    Tom Dayspring has long been a massive supporter of the lipid hypothesis and statins, so when someone like him goes low carb it is huge

    https://twitter.com/Drlipid/status/993488136088047616
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    Re: More Statin news

    Post by graham64 on Thu May 17 2018, 22:48

    @chris c wrote:Tom Dayspring has long been a massive supporter of the lipid hypothesis and statins, so when someone like him goes low carb it is huge

    https://twitter.com/Drlipid/status/993488136088047616

    Wow that's brilliant  Cool


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    Some Statins May Be Associated With Cognition, Memory Deficits

    Post by graham64 on Wed Jul 25 2018, 22:22

    CHICAGO — Lipophilic statins may be associated with memory and cognitive deficits in a dose-dependent manner, according to findings reported by University of Toronto researchers and presented at the 2018 Alzheimer's Association International Conference, July 22-26, 2018 in Chicago, Illinois. 

    The effect of HMG-CoA reductase inhibitors, also known as statins, on memory and cognition remains conflicting. Some literature have shown acute cognitive deficits after starting treatment whereas some have shown preventative effects against dementia with long-term treatment. "These mixed results in the literature may be attributed to a lack of rigorous studies distinguishing between lipophilic, blood-barrier permeable statins from hydrophilic impermeable statins, as well as a lack of objective clinical data acquired using detailed, valid measures," explained lead author Alex Kai Chan, from the Keenan Research Centre for Biomedical Research, St. Michael's Hospital, Toronto, Ontario, Canada.

    Chan and colleagues analyzed data from patients who were seen at the Memory Disorders Clinic at St. Michael's Hospital between 2012-2017. The control group consisted of patients not taking cholesterol-lowering drugs at time of admission, and the experimental group included adults taking atorvastatin (lipophilic statin) or rosuvastatin (hydrophilic statin) at time of admission.

    Data from T-tests showed significantly lower Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and total Behavioural Neurology Assessment (BNA-R) scores in the atorvastatin group vs controls. The mean assessment scores for atorvastatin were 25.17 for MMSE, 19.41 for MoCA, and .7339 for BNA-R compared with 26.64, 21.55, and .7856 for controls, respectively.

    Also, the atorvastatin group showed significantly lower BNA-R subsection scores regarding memory immediate recall (.5113 vs .5926 [control]), delayed recall (.4114 vs .5136 [control]), and working memory/attention (.7122 vs .7718 [control]).

    There were no significant differences, however, between the rosuvastatin group and controls in any of the evaluated tests.

    Additional analyses further showed negative correlations between atorvastatin use and cognitive scores for all sections with significant associations found for delayed recall and visuospatial subsection scores on BNA-R (P <.05). In general, no differences in subjective complaints were seen with any of the group Neuropsychological Impairment Scale (NIS) scores. However, significant negative correlations were specifically observed between atorvastatin doses and Total Indices Circled (TIC), Verbal learning (LV), and Academic Skills (ACD) (P <.05). Given the lack of differences seen via the NIS, the authors suggested that subjective questionnaires may not be a trustworthy method to assess possible statin-associated cognitive deficits.

    "Findings from this investigation suggest that lipophilic, blood-brain barrier penetrable statins may be associated with deficits in cognition and memory, possibly in a dose-dependent relationship," concluded Chan.

    https://www.neurologyadvisor.com/aaic-2018/statin-use-linked-to-cognitive-memory-deficits/article/783083/


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