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    Some More Studies

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    chris c
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    Some More Studies

    Post by chris c on Sun Feb 25 2018, 21:34

    Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month
    Weight Loss in Overweight Adults and the Association
    With Genotype Pattern or Insulin Secretion
    The DIETFITS Randomized Clinical Tria

    http://sci-hub.hk/10.1001/jama.2018.0245

    Chris Gardner did the ATOZ study (listed in the references) he is a vegan (or at least a vegetarian) so I was impressed that he published the results showing the Atkins diet in a favourable light.

    He seems to have been a bit more careful this time

    "There were improvements in the secondary outcomes
    for both diet groups. However, there were no significant
    between-group differences observed for body mass index,
    body fat percentage, and waist circumference (Table 3).
    At 12 months relative to baseline, both diets improved lipid
    profiles and lowered blood pressure, insulin, and glucose levels,
    with the exception of low-density lipoprotein cholesterol
    concentrations, which increased for participants in the healthy
    low-carbohydrate group (Table 3). The 12-month changes in
    low-density lipoprotein cholesterol concentrations significantly
    favored a healthy low-fat diet. High-density lipoprotein
    cholesterol concentrations increased significantly more
    and concentrations of triglycerides decreased significantly
    more for the healthy low-carbohydrate diet group than for
    the healthy low-fat diet group. The decrease in the prevalence
    of the metabolic syndrome was not significantly different
    between the diet groups."

    Already being used to claim that low fat diets should be used instead of low carb because there is no difference.

    Actually it is NOT a low carb diet and not that different from the low fat one.

    A low-fat vegan diet and a conventional diabetes diet in the treatment
    of type 2 diabetes: a randomized, controlled, 74-wk clinical trial1–4
    Neal D Barnard, Joshua Cohen, David JA Jenkins, Gabrielle Turner-McGrievy, Lise Gloede, Amber Green, and
    Hope Ferdowsian

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677007/pdf/ajcn8951588S.pdf

    Hb A1c
    changes from baseline to 74 wk or last available values were
    - 0.34 and - 0.14 for vegan and conventional diets, respectively
    (P ¼ 0.43)

    Nothing to see here, move along . . .

    How evidence-based medicine is failing due to biased trials
    and selective publication

    http://sci-hub.hk/10.1111/jep.12147

    "Abstract
    Evidence-based medicine (EBM) was announced in the early 1990s as a ‘new paradigm’
    for improving patient care. Yet there is currently little evidence that EBM has achieved its
    aim. Since its introduction, health care costs have increased while there remains a lack of
    high-quality evidence suggesting EBM has resulted in substantial population-level health
    gains. In this paper we suggest that EBM’s potential for improving patients’ health care has
    been thwarted by bias in the choice of hypotheses tested, manipulation of study design and
    selective publication. Evidence for these flaws is clearest in industry-funded studies. We
    argue EBM’s indiscriminate acceptance of industry-generated ‘evidence’ is akin to letting
    politicians count their own votes. Given that most intervention studies are industry funded,
    this is a serious problem for the overall evidence base. Clinical decisions based on such
    evidence are likely to be misinformed, with patients given less effective, harmful or more
    expensive treatments. More investment in independent research is urgently required. Independent
    bodies, informed democratically, need to set research priorities. We also propose
    that evidence rating schemes are formally modified so research with conflict of interest bias
    is explicitly downgraded in value"

      Current date/time is Fri May 25 2018, 23:28