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    Carbohydrate-restriction with Postmeal Walking Effectively Mitigates Postprandial Hyperglycemia and Improves Endothelial Function in Type 2 Diabetes

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    graham64
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    Carbohydrate-restriction with Postmeal Walking Effectively Mitigates Postprandial Hyperglycemia and Improves Endothelial Function in Type 2 Diabetes

    Post by graham64 on Wed Oct 18 2017, 22:21

    Abstract

    Postprandial hyperglycemia has deleterious effects on endothelial function. Restricting carbohydrate intake and postmeal walking have each been shown to reduce postprandial hyperglycemia but their combination and subsequent effects on endothelial function have not been investigated. Here, we sought to examine the effect of blunting postprandial hyperglycemia by following a low-carbohydrate diet, with or without postmeal walking exercise, on markers of vascular health in type 2 diabetes (T2D). In a randomized crossover design, individuals with T2D (N=11) completed three four-day controlled diet interventions consisting of i) low-carbohydrate diet alone (LC), ii) low-carbohydrate diet with 15-minute postmeal walks (LC+Ex), and iii) Low-fat control diet (CON). Fasting blood samples and brachial artery flow-mediated dilation (%FMD) were measured before and after each intervention. Total circulating microparticles (MPs), endothelial MPs (EMPs), platelet MPs (PMPs), monocyte-platelet aggregates (MPAs), and adhesion molecules were assessed as biomarkers of vascular health. There was a significant conditionXtime interaction for %FMD (p=0.01), with post-hoc tests revealing improved %FMD after LC+Ex (+0.8±1.0%, p=0.02), with no change after LC or CON. EMPs were significantly reduced with the LC diet by ~45% (from 99±60 to 44±31 MP/μL, p=0.02), with no change after LC+Ex or CON (interaction: p=0.04). Total MPs were lower (main effect time: p=0.02), whereas, MPAs were higher (main effect time: p<0.01) after all interventions. Plasma adhesion molecules and c-reactive protein were unaltered. Attenuating postprandial hyperglycemic excursions using a low-carbohydrate diet combined with postmeal walking appears to be an effective strategy to improve endothelial function in individuals with T2D.

    http://ajpheart.physiology.org/content/early/2017/10/13/ajpheart.00524.2017


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    chris c
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    Re: Carbohydrate-restriction with Postmeal Walking Effectively Mitigates Postprandial Hyperglycemia and Improves Endothelial Function in Type 2 Diabetes

    Post by chris c on Fri Oct 20 2017, 21:55

    Oh good to see scientists actually testing what Real People know! Yes I can deal with substantially more carbs when necessary (ie. eating out) by walking immediately after eating. Walking an hour or more after the meal no longer shifts my BG much but by then I'm probably back to burning ketones.

    Probably wouldn't help much if you eat those "heart healthy" vegetable oils though

    http://www.jbc.org/content/287/14/11398.short
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    chris c
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    Re: Carbohydrate-restriction with Postmeal Walking Effectively Mitigates Postprandial Hyperglycemia and Improves Endothelial Function in Type 2 Diabetes

    Post by chris c on Sun Oct 22 2017, 23:09

    I broke into the complete paper

    http://sci-hub.bz/10.1152/ajpheart.00524.2017

    Excellent read!

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    graham64
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    Re: Carbohydrate-restriction with Postmeal Walking Effectively Mitigates Postprandial Hyperglycemia and Improves Endothelial Function in Type 2 Diabetes

    Post by graham64 on Mon Oct 23 2017, 22:45

    @chris c wrote:I broke into the complete paper

    http://sci-hub.bz/10.1152/ajpheart.00524.2017

    Excellent read!


    Thanks Chris it is an excellent read, obviously unbiased authors and a fair representation of low carb


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    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over ten years

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes

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