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    Short-term effects of a low carb diet in T1 diabetes

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    graham64
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    Short-term effects of a low carb diet in T1 diabetes

    Post by graham64 on Sun Sep 24 2017, 22:17

    Abstract

    The aim of the present study was to assess the effects of a high carbohydrate diet (HCD) vs a low carbohydrate diet (LCD) on glycaemic variables and cardiovascular risk markers in patients with type 1 diabetes. Ten patients (4 women, insulin pump-treated, median ± standard deviation [s.d.] age 48 ± 10 years, glycated haemoglobin [HbA1c] 53 ± 6 mmol/mol [7.0% ± 0.6%]) followed an isocaloric HCD (≥250 g/d) for 1 week and an isocaloric LCD (≤50 g/d) for 1 week in random order. After each week, we downloaded pump and sensor data and collected fasting blood and urine samples. Diet adherence was high (225 ± 30 vs 47 ± 10 g carbohydrates/d; P < .0001). Mean sensor glucose levels were similar in the two diets (7.3 ± 1.1 vs 7.4 ± 0.6 mmol/L; P = .99). The LCD resulted in more time with glucose values in the range of 3.9 to 10.0 mmol/L (83% ± 9% vs 72% ± 11%; P = .02), less time with values ≤3.9 mmol/L (3.3% ± 2.8% vs 8.0% ± 6.3%; P = .03), and less glucose variability (s.d. 1.9 ± 0.4 vs 2.6 ± 0.4 mmol/L; P = .02) than the HCD. Cardiovascular markers were unaffected, while fasting glucagon, ketone and free fatty acid levels were higher at end of the LCD week than the HCD week. In conclusion, the LCD resulted in more time in euglycaemia, less time in hypoglycaemia and less glucose variability than the HCD, without altering mean glucose levels.

    Full text: http://onlinelibrary.wiley.com/doi/10.1111/dom.12953/full


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    chris c
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    Re: Short-term effects of a low carb diet in T1 diabetes

    Post by chris c on Sun Sep 24 2017, 23:18

    Excellent! AND authors whose names I don't recognise.

    Meanwhile here was Gerald Reaven et al from over 30 years ago laying into the ADA diet

    http://sci-hub.bz/10.1016/0002-9343(87)90058-1

    A long term study on obese/CVD patients

    http://sci-hub.bz/10.4065/78.11.1331

    Some more on ketogenic diets in various conditions

    http://insulinresistance.org/index.php/jir/article/view/25 (Ben Bikman)

    An interesting look at the differing effects of hyperglycemia and hyperinsulinemia

    http://www.bloodjournal.org/content/112/1/82?sso-checked=true

    Plus a load more I haven't read yet, thanks to the Malcolm Kendrick and his commentators (rapidly becoming one of the best blogs), and Raphi Sirt and Tucker Goodrich on Twitter, coming shortly . . .

      Current date/time is Wed Jan 24 2018, 03:46