The Low Carb Diabetic

Promoting a low carb high fat lifestyle for the safe control of diabetes. Eat whole fresh food, more drugs are not the answer.


Welcome to the Low Carb Diabetic forum,have you signed up yet? if not then sign up and join us in the low carb community today!

    The effect of statins on average survival in randomised trials, an analysis of end point postponement

    Share
    avatar
    graham64
    Member

    Status :
    Online
    Offline

    Male Posts : 2802
    Join date : 2014-08-10
    Location : Lancs

    The effect of statins on average survival in randomised trials, an analysis of end point postponement

    Post by graham64 on Wed Apr 12 2017, 22:34

    Abstract

    Objective To estimate the average postponement of death in statin trials.

    Setting A systematic literature review of all statin trials that presented all-cause survival curves for treated and untreated.

    Intervention Statin treatment compared to placebo.

    Primary outcome measures The average postponement of death as represented by the area between the survival curves.

    Results 6 studies for primary prevention and 5 for secondary prevention with a follow-up between 2.0 and 6.1 years were identified. Death was postponed between −5 and 19 days in primary prevention trials and between −10 and 27 days in secondary prevention trials. The median postponement of death for primary and secondary prevention trials were 3.2 and 4.1 days, respectively.

    Conclusions Statin treatment results in a surprisingly small average gain in overall survival within the trials’ running time. For patients whose life expectancy is limited or who have adverse effects of treatment, withholding statin therapy should be considered.

    http://bmjopen.bmj.com/content/5/9/e007118


    _________________
    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over nine years,

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
    avatar
    chris c
    Member

    Status :
    Online
    Offline

    Posts : 2904
    Join date : 2015-07-26

    Re: The effect of statins on average survival in randomised trials, an analysis of end point postponement

    Post by chris c on Thu Apr 13 2017, 21:59

    Well fuck me gently with a chainsaw, now they are coming off patent and being replaced by PCSK9s they start telling the truth about statins.

    Be VEWY VEWY quiet about the fact PCSK9s don't appear to prolong or improve life expectancy either.
    avatar
    graham64
    Member

    Status :
    Online
    Offline

    Male Posts : 2802
    Join date : 2014-08-10
    Location : Lancs

    Re: The effect of statins on average survival in randomised trials, an analysis of end point postponement

    Post by graham64 on Thu Apr 13 2017, 22:20

    @chris c wrote:Well fuck me gently with a chainsaw, now they are coming off patent and being replaced by PCSK9s they start telling the truth about statins.

    Be VEWY VEWY quiet about the fact PCSK9s don't appear to prolong or improve life expectancy either.

    Yes very limited data available on the efficiency of PCSK9s given time expect the same eventual conclusions as statins though no doubt pharma will be funding studies extolling the virtues


    _________________
    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over nine years,

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
    avatar
    chris c
    Member

    Status :
    Online
    Offline

    Posts : 2904
    Join date : 2015-07-26

    Re: The effect of statins on average survival in randomised trials, an analysis of end point postponement

    Post by chris c on Thu Apr 13 2017, 22:55

    Meanwhile even "Mediterranean" diets (whateverthehell they are) blow these results into the weeds. Let alone what is routinely achieved by low carb/ketosis.
    avatar
    graham64
    Member

    Status :
    Online
    Offline

    Male Posts : 2802
    Join date : 2014-08-10
    Location : Lancs

    Re: The effect of statins on average survival in randomised trials, an analysis of end point postponement

    Post by graham64 on Fri Apr 14 2017, 23:01

    @chris c wrote:Meanwhile even "Mediterranean" diets (whateverthehell they are) blow these results into the weeds. Let alone what is routinely achieved by low carb/ketosis.

    The Mediterranean diet according to the NHS is similar to the eatwell diet  Rolling Eyes

    The diet is similar to the government's healthy eating advice set out in the Eatwell Guide, which shows the foods needed for a balanced, healthy diet.

    http://www.nhs.uk/Livewell/Goodfood/Pages/what-is-a-Mediterranean-diet.aspx



    _________________
    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over nine years,

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
    avatar
    chris c
    Member

    Status :
    Online
    Offline

    Posts : 2904
    Join date : 2015-07-26

    Re: The effect of statins on average survival in randomised trials, an analysis of end point postponement

    Post by chris c on Sat Apr 15 2017, 22:12

    More nutribollocks.

    Michel de Lorgeril's study actually replaced industrially produced Omega 6 oils with industrially produced Omega 3 oils, which was enough to make some significant changes in outcomes. This passed the NHS by completely, as did what they ACTUALLY eat around the Med.

    There were a couple of admittedly small but convincing studies by the late Staffan Lindeberg where a pseudo-Paleo diet blew away a pseudo-Mediterranean diet, one in diabetics, one in obese people. Basically the NHS is just pushing a high carb low fat Omega 6 rich veg(etari)an diet, just like Coke and PETA require.

      Current date/time is Mon Jun 26 2017, 01:15