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    Diabetes drug shows promise for safely treating, detecting Alzheimer's disease

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    yoly
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    Diabetes drug shows promise for safely treating, detecting Alzheimer's disease

    Post by yoly on Thu Mar 09 2017, 15:16

    (Another study pointing to Alzheimer's being diabetes on the brain, the drug is given to type 1 becuase they don't produce insulin so they have no amylin)

    https://en.wikipedia.org/wiki/Amylin

    Amylin, or islet amyloid polypeptide (IAPP), is a 37-residue peptide hormone.[3] It is cosecreted with insulin from the pancreatic β-cells in the ratio of approximately 100:1. Amylin plays a role in glycemic regulation by slowing gastric emptying and promoting satiety, thereby preventing post-prandial spikes in blood glucose levels.)

    Diabetes drug shows promise for safely treating, detecting Alzheimer's disease

    (Boston)-- As the number of patients with Alzheimer's disease (AD) rapidly increases, new treatments as well as blood tests that are simple and can be easily performed in a doctor's office to diagnose are urgently needed.

    A new study has found treatment with the diabetes drug amylin (or pramlintide) safely improves learning and memory function in AD patients and reduces the AD pathology in their brains. The findings, which appear in the Journal Translational Research and Clinical Interventions, also may lead to the development of a blood test for AD.

    Currently, lumbar punctures to detect biomarkers in cerebrospinal fluid and positron emission tomography imaging scans are used to diagnose AD. Unfortunately many patients are fearful of these procedures and the high cost is prohibitive.

    "A single injection of pramlintide into our patients was well tolerated and reduced the amyloid burden as well as lowered the concentrations of amyloid-β peptides, a major component of AD in the brain," explained corresponding author Wendy Qiu, MD, PhD, associate professor of psychiatry and pharmacology and experimental therapeutics at Boston University School of Medicine.

    "Our study suggests a potential role for the creation of a blood test that relies on pramlintide, which could cross the blood-brain barrier and help to translocate the biomarkers related to AD pathology including amyloid-β peptides and neuroinflammation, from the brain into the bloodstream where they can be detected," added Qiu.

    ###

    Funding for this study was provided by grants from the Alzheimer's Disease Association (IIRG-13-284238), NIA (R21 AG045757A1), and Ignition Award (to W.Q.Q), and from Boston University Alzheimer's Disease Center pilot grant (to H.Z.).

    https://www.eurekalert.org/pub_releases/2017-03/bumc-dds030817.php
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    Eddie
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    Re: Diabetes drug shows promise for safely treating, detecting Alzheimer's disease

    Post by Eddie on Thu Mar 09 2017, 16:35

    @yoly wrote:(Another study pointing to Alzheimer's being diabetes on the brain, the drug is given to type 1 becuase they don't produce insulin so they have no amylin)

    https://en.wikipedia.org/wiki/Amylin

    Amylin, or islet amyloid polypeptide (IAPP), is a 37-residue peptide hormone.[3] It is cosecreted with insulin from the pancreatic β-cells in the ratio of approximately 100:1. Amylin plays a role in glycemic regulation by slowing gastric emptying and promoting satiety, thereby preventing post-prandial spikes in blood glucose levels.)

    Diabetes drug shows promise for safely treating, detecting Alzheimer's disease

    (Boston)-- As the number of patients with Alzheimer's disease (AD) rapidly increases, new treatments as well as blood tests that are simple and can be easily performed in a doctor's office to diagnose are urgently needed.

    A new study has found treatment with the diabetes drug amylin (or pramlintide) safely improves learning and memory function in AD patients and reduces the AD pathology in their brains. The findings, which appear in the Journal Translational Research and Clinical Interventions, also may lead to the development of a blood test for AD.

    Currently, lumbar punctures to detect biomarkers in cerebrospinal fluid and positron emission tomography imaging scans are used to diagnose AD. Unfortunately many patients are fearful of these procedures and the high cost is prohibitive.

    "A single injection of pramlintide into our patients was well tolerated and reduced the amyloid burden as well as lowered the concentrations of amyloid-β peptides, a major component of AD in the brain," explained corresponding author Wendy Qiu, MD, PhD, associate professor of psychiatry and pharmacology and experimental therapeutics at Boston University School of Medicine.

    "Our study suggests a potential role for the creation of a blood test that relies on pramlintide, which could cross the blood-brain barrier and help to translocate the biomarkers related to AD pathology including amyloid-β peptides and neuroinflammation, from the brain into the bloodstream where they can be detected," added Qiu.

    ###

    Funding for this study was provided by grants from the Alzheimer's Disease Association (IIRG-13-284238), NIA (R21 AG045757A1), and Ignition Award (to W.Q.Q), and from Boston University Alzheimer's Disease Center pilot grant (to H.Z.).

    https://www.eurekalert.org/pub_releases/2017-03/bumc-dds030817.php

    Interesting Yoly I hope it works better for Alzheimer's Disease than it does for diabetics.



    From here  http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021332s007_S016.pdf

    According to this site the drug is very expensive at around $850 for two pens. https://www.goodrx.com/symlinpen


    _________________
    Type two diabetic-low carb diet (50 carbs per day) and two 500mg Metformin pills per day. Apart from diagnosis HbA1c almost 12-all HbA1c results none diabetic. For over eight years my diabetes medication has not changed. My weight has remained stable, I have suffered no ill effects from my diet whatsoever. Every blood test has proved, I took the right road to my diabetic salvation. For almost seven years, I have asked medical professionals and naysayers, how do I maintain non diabetic BG levels on two Metformin other than low carb ? The silence has been deafening !

      Current date/time is Sun Oct 21 2018, 14:00