The Low Carb Diabetic

Promoting a low carb high fat lifestyle for the safe control of diabetes. Eat whole fresh food, more drugs are not the answer.


Welcome to the Low Carb Diabetic forum,have you signed up yet? if not then sign up and join us in the low carb community today!

    Metformin and Resveratrol, a compound found in red wine, protects neuromuscular synapses, muscle fibers in aging mice

    Share
    avatar
    yoly
    Member

    Status :
    Online
    Offline

    Posts : 390
    Join date : 2014-08-14

    Metformin and Resveratrol, a compound found in red wine, protects neuromuscular synapses, muscle fibers in aging mice

    Post by yoly on Wed Mar 08 2017, 12:51

    Resveratrol, a compound found in red wine, protects neuromuscular synapses, muscle fibers in aging mice

    Scientists from Virginia Tech Carilion Research Institute have discovered that resveratrol, a compound in the skin of red grapes and red wine, and metformin, a drug often prescribed to fight type 2 diabetes, have many of the neuroprotective benefits of a low-calorie diet and exercise. The study was led by Greg Valdez (center) with (from left) Dillon Shapiro, who is an undergraduate student researcher at Virginia Tech, and Nicholas Maxwell of the Virginia Tech Carilion Research Institute.

    Scientists have discovered that resveratrol, a compound in the skin of red grapes and red wine, and metformin, a drug often prescribed to fight type 2 diabetes, have many of the neuroprotective benefits of a low-calorie diet and exercise.

    In a study published today in The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, scientists from the Virginia Tech Carilion Research Institute and colleagues show resveratrol preserves muscle fibers as we age and helps protect connections between neurons called synapses from the negative effects of aging.

    “We all slow down as we get older,” said Gregorio Valdez, an assistant professor at the Virginia Tech Carilion Research Institute. “Gait, balance issues, and impaired motor coordination contribute to health problems, accidents, lack of mobility, and a lower quality of life. We work on identifying molecular changes that slow down motor deficits that occur with aging. I believe that we are getting closer to tapping into mechanisms to slow age-induced degeneration of neuronal circuits.”

    Scientists studied two-year-old mice — generally considered to be “old”— that were treated with resveratrol for one year, paying particular attention to synapses called neuromuscular junctions. These synapses are essential for voluntary movement because they relay motor commands that flow from neurons in the spinal cord to muscles.

    Previously Valdez discovered that optimum diet and exercise can protect neuromuscular junction synapses from the wear and tear of aging.

    In this study, the researchers show resveratrol — a small, naturally occurring molecule well known as a chemical component of red wine — can have a similar beneficial effect.

    The scientists also discovered that the diabetes drug metformin slowed the rate of muscle fiber aging, but it did not significantly affect aging of neuromuscular junctions. However, the drug may possibly protect synapses in different dosage amounts, Valdez said.

    “Metformin is an FDA-approved drug to treat diabetes, but our study hints it may also serve the purpose of slowing the motor dysfunction that occurs with aging,” Valdez said. “There could be an opportunity for researchers and medical doctors to look at the patient population using this drug and ask whether metformin also has a positive effect on motor and cognitive function in humans.”

    Valdez said people would not get the massive neuroprotective benefits seen in mice by drinking wine because of the relatively low resveratrol content.

    “In wine, resveratrol is in such small amounts you could not drink enough of it in your life to have the benefits we found in mice given resveratrol,” Valdez said. “These studies are in mice and I would caution anyone from blasting their bodies with resveratrol in any form. The next step is to identify the mechanism that enables resveratrol to protect synapses. If we know the mechanism, we can modify resveratrol or look for other molecules that are more effective at protecting the synapses.”

    Rafael de Cabo, an investigator with the Experimental Gerontology Section of the National Institute of Aging, was a co-author of the study, along with Valdez lab members Dillon Shapiro, an undergraduate biological sciences researcher at Virginia Tech; lab manager Nicholas Maxwell of the Virginia Tech Carilion Research Institute, and Jessica Stockinger, an undergraduate student at Roanoke College.

    The study was supported by the National Institute of Neurological Disorders and Stroke, the National Institute on Aging, and the Virginia Tech Carilion Research Institute.

    http://vtnews.vt.edu/articles/2017/03/resveratrol-vtrcri-030717.html

    avatar
    Jan1
    Member

    Status :
    Online
    Offline

    Female Posts : 4020
    Join date : 2014-08-13

    Re: Metformin and Resveratrol, a compound found in red wine, protects neuromuscular synapses, muscle fibers in aging mice

    Post by Jan1 on Wed Mar 08 2017, 19:06

    Thanks for this Yoly ...

    Resveratol linked:

    There was also a recent article on Authority Nutrition regarding 'Health Benefits of Resveratol

    "If you’ve heard that red wine can help lower cholesterol, chances are you’ve heard of resveratrol — the much-hyped plant compound found in red wine.
    But beyond being a healthful part of red wine and other foods, resveratrol has health-boosting potential in its own right.
    In fact, resveratrol supplements have been linked to many exciting health benefits, including protecting brain function and lowering blood pressure.
    This article explains what you need to know about resveratrol, including seven of its main potential health benefits."

    Read more here
    https://authoritynutrition.com/resveratrol/

    All the best Jan
    avatar
    chris c
    Member

    Status :
    Online
    Offline

    Posts : 3015
    Join date : 2015-07-26

    Re: Metformin and Resveratrol, a compound found in red wine, protects neuromuscular synapses, muscle fibers in aging mice

    Post by chris c on Thu Mar 09 2017, 00:21

    Metformin works among other things at the level of the mitochondria. I wonder if resveratrol does as well.

      Current date/time is Sun Jul 23 2017, 11:48