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    Vitamin D supplementation to prevent acute respiratory tract infections:

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    graham64
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    Vitamin D supplementation to prevent acute respiratory tract infections:

    Post by graham64 on Sun Feb 19 2017, 21:34

    Abstract

    Objectives To assess the overall effect of vitamin D supplementation on risk of acute respiratory tract infection, and to identify factors modifying this effect.

    Design Systematic review and meta-analysis of individual participant data (IPD) from randomised controlled trials.

    Data sources Medline, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, ClinicalTrials.gov, and the International Standard Randomised Controlled Trials Number registry from inception to December 2015.

    Eligibility criteria for study selection Randomised, double blind, placebo controlled trials of supplementation with vitamin D3 or vitamin D2 of any duration were eligible for inclusion if they had been approved by a research ethics committee and if data on incidence of acute respiratory tract infection were collected prospectively and prespecified as an efficacy outcome.

    Results 25 eligible randomised controlled trials (total 11 321 participants, aged 0 to 95 years) were identified. IPD were obtained for 10 933 (96.6%) participants. Vitamin D supplementation reduced the risk of acute respiratory tract infection among all participants (adjusted odds ratio 0.88, 95% confidence interval 0.81 to 0.96; P for heterogeneity <0.001). In subgroup analysis, protective effects were seen in those receiving daily or weekly vitamin D without additional bolus doses (adjusted odds ratio 0.81, 0.72 to 0.91) but not in those receiving one or more bolus doses (adjusted odds ratio 0.97, 0.86 to 1.10; P for interaction=0.05). Among those receiving daily or weekly vitamin D, protective effects were stronger in those with baseline 25-hydroxyvitamin D levels <25 nmol/L (adjusted odds ratio 0.30, 0.17 to 0.53) than in those with baseline 25-hydroxyvitamin D levels ≥25 nmol/L (adjusted odds ratio 0.75, 0.60 to 0.95; P for interaction=0.006). Vitamin D did not influence the proportion of participants experiencing at least one serious adverse event (adjusted odds ratio 0.98, 0.80 to 1.20, P=0.83). The body of evidence contributing to these analyses was assessed as being of high quality.

    Conclusions Vitamin D supplementation was safe and it protected against acute respiratory tract infection overall. Patients who were very vitamin D deficient and those not receiving bolus doses experienced the most benefit.

    Full text: http://www.bmj.com/content/356/bmj.i6583


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    chris c
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    Re: Vitamin D supplementation to prevent acute respiratory tract infections:

    Post by chris c on Tue Feb 21 2017, 00:13

    Vitamin D. It's a floor wax! It's a dessert topping! Well it does appear to be more of a hormone than a vitamin.

    I suspect one reason deficiency is endemic is sun avoidance, and since it's fat-soluble also fat avoidance, and of course because it is cholecalciferol statins probably don't help much. I wonder if it's one reason why I was always prone to minor but irritating infections and now I'm not, alongside the glucose of course.

      Current date/time is Sat Aug 19 2017, 23:32