THE LOW CARB DIABETIC

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THE LOW CARB DIABETIC

Promoting a low carb high fat lifestyle for the safe control of diabetes. Eat whole fresh food, more drugs are not the answer.


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    What do the studies really say about Type 2 diabetes drugs?

    graham64
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    What do the studies really say about Type 2 diabetes drugs? Empty What do the studies really say about Type 2 diabetes drugs?

    Post by graham64 Mon Sep 19 2016, 21:54

    It's not the first time Type 2 diabetes dogma has been questioned

    Cait O'Sullivan travelled all the way across the continent a few weeks ago to ask a question that's been haunting her for years. 

    It's her job to know how drugs work, and this was her chance to confront the regulators.

    It was a public meeting at the FDA's Washington, D.C., headquarters, and Health Canada officials would be there. 

    The main item on the agenda? Drug approval for Type 2 diabetes.

    O'Sullivan wanted them to state, on the public record, what scientific evidence they were using to support their approval of drugs for Type 2 diabetes.

    Because O'Sullivan has read the literature and she can't find it.

    After the meeting she flew back home to Vancouver Island empty handed.

    "I stood up to ask my question, and they said no more questions." O'Sullivan said. "It was a disappointing experience."

    But O'Sullivan is not the first to challenge the basis for tight blood sugar control in the treatment of Type 2 diabetes. 

    A Cochrane review in 2013, a  BMJ paper in 2014, and most recently a literature review from the Mayo Clinic in Rochester, Minn., have all investigated the evidence and found it lacking.

    New study questions Type 2 diabetes treatment

    It matters because millions of people are taking these drugs.

    The theory is that using medication to tightly control blood sugar in type 2 diabetes will prevent the deterioration of tiny blood vessels which can lead to damage in kidneys, eyes and other parts of the body, a composite outcome called "microvascular complications."

    But curiously, the studies failed to show a corresponding drop in the risk of blindness, nor a reduction in the rate of kidney failure.

    And none of the studies have shown that tight glucose control reduces the risk of frightening complications like stroke, fatal heart attacks, or death from all causes . 

    One small positive finding persists: a slight reduction in the risk of a non-fatal heart attack. But the risk of death from heart attack doesn't change.

    What some researchers are asking is whether the evidence justifies millions of people taking drugs for decades, and risking side effects, which can include weight gain and the possibility of serious hypoglycemia, which can cause coma and death.
     
    Same data, different interpretations

    In medical journalism, it's a major challenge trying to reflect the uncertainty that is inherent in biomedical research. There's a perception that science delivers straightforward, objective answers.

    But interpretations can be surprisingly subjective, even though everyone is using the same data.

    Witness the raging debate over the use of statins that has pitted two of the world's most prestigious medical journals in an increasingly heated argument over the evidence for some of the most commonly prescribed drugs in the world. 
     
    The debate over tight glucose control in type 2 diabetes has been less public, but it has been simmering in the professional community for years.

    Calgary doctor disputes latest study on Type 2 diabetes treatment

    No one is suggesting that the drugs be tossed out, or that attention to glucose control should be recklessly abandoned.
    In his paper, Dr. Victor Montori called for a "careful and thoughtful recalibration," saying "a skeptical view may be necessary."

    Decades ago, a patient would be diagnosed with Type 2 diabetes based on symptoms of acute high blood sugar including excessive thirst, frequent urination, and blurred vision.  Experts still agree that those symptoms should be immediately treated with glucose lowering drugs.

    The evidence gap

    But today, most patients have no symptoms. They find out they have Type 2 diabetes after a routine blood test. Should they also be given drugs to hit the tight glucose levels?  This is where the evidence gap lies.

    Back in her home on Vancouver Island, Cait O'Sullivan continues her work for the B.C. Ministry of Health, educating family doctors about the evidence behind the drugs they're prescribing.

    When she tells them about the debate over type 2 diabetes drugs, they are often surprised.

    "They look at me as though they've never heard of the inquiry into the science behind it," she said. 

    It's a debate that can only be resolved with more study and better data. That's why O'Sullivan's group is calling on Health Canada to demand better evidence when they approve type 2 diabetes drugs.

    Right now Health Canada only requires evidence that the drugs lower blood sugar, and don't increase the risk of cardiovascular disease.

    "What we would need is evidence that the drugs improve the longevity of people's lives or reduce their risk of developing any disability associated with diabetes," O'Sullivan said.

    But those questions are unlikely to be asked if the belief persists that they've already been answered.

    http://www.cbc.ca/news/health/type-2-diabetes-tight-glucose-control-controversy-debate-1.3766333
    chris c
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    What do the studies really say about Type 2 diabetes drugs? Empty Re: What do the studies really say about Type 2 diabetes drugs?

    Post by chris c Tue Sep 20 2016, 21:51

    Obviously it's the drugs, not the BG lowering, or nondiabetics would be keeling over right left and centre.

    EPIC Norfolk

    Elley et al

    Brewer et al

    Then there are studies I can't recall now which show HbA1c correlates to microvascular complications but postprandial spikes correlate to macrovascular complications.


    Last edited by chris c on Tue Sep 20 2016, 21:56; edited 1 time in total (Reason for editing : pressed wrong tit)
    graham64
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    What do the studies really say about Type 2 diabetes drugs? Empty Re: What do the studies really say about Type 2 diabetes drugs?

    Post by graham64 Tue Sep 20 2016, 22:21

    chris c wrote:Obviously it's the drugs, not the BG lowering, or nondiabetics would be keeling over right left and centre.

    EPIC Norfolk

    Elley et al

    Brewer et al

    Then there are studies I can't recall now which show HbA1c correlates to microvascular complications but postprandial spikes correlate to macrovascular complications.

    They are never going to admit drugs are the problem, low carb can safely do the job but hey it's not recommended because there are no long term studies  and it's not approved by dietitians  facepalm
    chris c
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    Post by chris c Thu Sep 22 2016, 22:44

    There are no long term studies because THEY are not approved by dieticians. Thus we remain just anecdotes - now thousands of them.
    graham64
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    Post by graham64 Fri Sep 23 2016, 22:01

    chris c wrote:There are no long term studies because THEY are not approved by dieticians. Thus we remain just anecdotes - now thousands of them.

    Anecdotal maybe but we do have absolute proof in our medical records that show the efficacy of low carb, that said I've yet to see a long term study on the effects of the BDA/DUK diet on diabetes.
    Eddie
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    Post by Eddie Sat Sep 24 2016, 17:38

    Most T2 drugs are useless, all come with a long list of side effects. Now, one thing the medics agree on is smoking is bad for us. That being said, maybe the cure is worse than being addicted to fags. Check this genuine advert out for an anti smoking drug.  rofl

    chris c
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    Post by chris c Sun Sep 25 2016, 21:48

    graham64 wrote:
    Anecdotal maybe but we do have absolute proof in our medical records that show the efficacy of low carb, that said I've yet to see a long term study on the effects of the BDA/DUK diet on diabetes.

    Come to that there haven't been any positive studies on high carb low fat, and they don't need long term ones to KNOW they are right despite the "epidemics" of obesity, diabetes, etc. which were non-existent prior to low fat.

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