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    Use of Statins and the Risk of Incident Diabetes: A Retrospective Cohort Study

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    graham64
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    Use of Statins and the Risk of Incident Diabetes: A Retrospective Cohort Study

    Post by graham64 on Fri Jun 10 2016, 21:44

    Abstract

    Introduction


    Even though several landmark statin trials have demonstrated the beneficial effects of statin therapy in both primary and secondary prevention of cardiovascular disease, several studies have suggested that statins are associated with a moderate increase in risk of new-onset diabetes. These observations prompted the US FDA to revise statin labels to include a warning of an increased risk of incident diabetes mellitus as a result of increases in glycosylated hemoglobin (HbA1c) and fasting plasma glucose. However, few studies have used US-based data to investigate this statin-associated increased risk of diabetes.

    Objective

    The primary objective of our study was to examine whether the use of statins increases the risk of incident diabetes mellitus using data from the Thomson Reuters MarketScan ® Commercial Claims and Encounters Database.

    Method

    This study was a retrospective cohort analysis utilizing data for the period 2003–2004. The study population included new statin users aged 20–63 years at index who did not have a history of diabetes.

    Results

    The proportion (3.4 %) of statin users (N = 53,212) who had incident diabetes was higher than the proportion (1.2 %) of non-statin users (N = 53,212) who had incident diabetes. Compared with no statin use and controlling for demographic and clinical covariates, statin use was significantly associated with increased risk of incident diabetes (hazard ratio 2.01; 99 % confidence interval 1.74–2.33; p < 0.0001). In addition, risk of diabetes was highest among users of lovastatin, atorvastatin, simvastatin, and fluvastatin. Diabetes risk was lowest among pravastatin and rosuvastatin users.

    Discussion

    Because the potential for diabetogenicity differs among different statin types, healthcare professionals should individualize statin therapy by identifying patients who would benefit more from less diabetogenic statin types.

    http://link.springer.com/article/10.1007%2Fs40256-016-0176-1


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    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

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    Derek
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    Re: Use of Statins and the Risk of Incident Diabetes: A Retrospective Cohort Study

    Post by Derek on Fri Jun 10 2016, 22:54

    Interesting article Graham, will bear that in mind when I get pressured to take statins next diabetic appointment...next Thursday.
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    graham64
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    Re: Use of Statins and the Risk of Incident Diabetes: A Retrospective Cohort Study

    Post by graham64 on Fri Jun 10 2016, 23:02

    @Derek wrote:Interesting article Graham, will bear that in mind when I get pressured to take statins next diabetic appointment...next Thursday.

    Check out my source Derek lots more information on statins and their side effects

    http://healthydietsandscience.blogspot.co.uk/


    _________________
    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over nine years,

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes

      Current date/time is Thu May 25 2017, 11:32