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    Vitamin D could repair nerve damage in multiple sclerosis, study suggests

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    graham64
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    Vitamin D could repair nerve damage in multiple sclerosis, study suggests

    Post by graham64 on Fri Dec 18 2015, 22:25

    A protein activated by vitamin D could be involved in repairing damage to myelin in people with multiple sclerosis (MS), according to new research from the University of Cambridge. The study, published today in the Journal of Cell Biology, offers significant evidence that vitamin D could be a possible treatment for MS in the future.

    Researchers, from the MS Society Cambridge Centre for Myelin Repair, identified that the ‘vitamin D receptor’ protein pairs with an existing protein, called the RXR gamma receptor, already known to be involved in the repair of myelin, the protective sheath surrounding nerve fibres.

    By adding vitamin D to brain stem cells where the proteins were present, they found the production rate of oligodendrocytes (myelin making cells) increased by 80%. When they blocked the vitamin D receptor to stop it from working, the RXR gamma protein alone was unable to stimulate the production of oligodendrocytes.

    In MS, the body’s own immune system attacks and damages myelin, causing disruption to messages sent around the brain and spinal cord; symptoms are unpredictable and include problems with mobility and balance, pain, and severe fatigue. The body has a natural ability to repair myelin, but with age this becomes less effective.

    Professor Robin Franklin from the MS Society Cambridge Centre for Myelin Repair and the Wellcome Trust-Medical Research Council Stem Cell Institute, who led the study, says: “For years scientists have been searching for a way to repair damage to myelin. So far, the majority of research on vitamin D has looked at its role in the cause of the disease. This work provides significant evidence that vitamin D is also involved in the regeneration of myelin once the disease has started. In the future we could see a myelin repair drug that works by targeting the vitamin D receptor.”

    Dr Susan Kohlhaas, Head of Biomedical Research at the MS Society, said: “More than 100,000 people in the UK have multiple sclerosis and finding treatments that can slow, stop or reverse the worsening of disability is a priority for the MS Society. We’d now like to see more studies to understand whether taking vitamin D supplements could, in time, be an effective and safe treatment for people with MS.

    She continued: “For now though, this is early stage research that’s been done in the laboratory and more work is needed before we know whether it would hold true in people with MS. It’s not a good idea, however, to be deficient in vitamin D and we’d encourage anybody who thinks they might be to speak to their GP.”

    Following this research, scientists will need to understand more about the underlying biology of this receptor before considering how the vitamin D receptor could be safely and effectively targeted in future trials in people with MS.

    http://www.cam.ac.uk/research/news/vitamin-d-could-repair-nerve-damage-in-multiple-sclerosis-study-suggests


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    Jan1
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    Re: Vitamin D could repair nerve damage in multiple sclerosis, study suggests

    Post by Jan1 on Wed Dec 30 2015, 19:37

    graham64 wrote:A protein activated by vitamin D could be involved in repairing damage to myelin in people with multiple sclerosis (MS), according to new research from the University of Cambridge. The study, published today in the Journal of Cell Biology, offers significant evidence that vitamin D could be a possible treatment for MS in the future.

    Researchers, from the MS Society Cambridge Centre for Myelin Repair, identified that the ‘vitamin D receptor’ protein pairs with an existing protein, called the RXR gamma receptor, already known to be involved in the repair of myelin, the protective sheath surrounding nerve fibres.

    By adding vitamin D to brain stem cells where the proteins were present, they found the production rate of oligodendrocytes (myelin making cells) increased by 80%. When they blocked the vitamin D receptor to stop it from working, the RXR gamma protein alone was unable to stimulate the production of oligodendrocytes.

    In MS, the body’s own immune system attacks and damages myelin, causing disruption to messages sent around the brain and spinal cord; symptoms are unpredictable and include problems with mobility and balance, pain, and severe fatigue. The body has a natural ability to repair myelin, but with age this becomes less effective.

    Professor Robin Franklin from the MS Society Cambridge Centre for Myelin Repair and the Wellcome Trust-Medical Research Council Stem Cell Institute, who led the study, says: “For years scientists have been searching for a way to repair damage to myelin. So far, the majority of research on vitamin D has looked at its role in the cause of the disease. This work provides significant evidence that vitamin D is also involved in the regeneration of myelin once the disease has started. In the future we could see a myelin repair drug that works by targeting the vitamin D receptor.”

    Dr Susan Kohlhaas, Head of Biomedical Research at the MS Society, said: “More than 100,000 people in the UK have multiple sclerosis and finding treatments that can slow, stop or reverse the worsening of disability is a priority for the MS Society. We’d now like to see more studies to understand whether taking vitamin D supplements could, in time, be an effective and safe treatment for people with MS.

    She continued: “For now though, this is early stage research that’s been done in the laboratory and more work is needed before we know whether it would hold true in people with MS. It’s not a good idea, however, to be deficient in vitamin D and we’d encourage anybody who thinks they might be to speak to their GP.”

    Following this research, scientists will need to understand more about the underlying biology of this receptor before considering how the vitamin D receptor could be safely and effectively targeted in future trials in people with MS.

    http://www.cam.ac.uk/research/news/vitamin-d-could-repair-nerve-damage-in-multiple-sclerosis-study-suggests

    "Multiple sclerosis (MS) is a neurological condition which affects around 100,000 people in the UK.

    Most people are diagnosed between the ages of 20-40, but it can affect younger and older people too.

    Roughly three times as many women have MS as men."

    These details taken from here https://www.mssociety.org.uk/what-is-ms

    Speaking from personal experience I know women who do have MS, and I do wonder why it is women who tend to be three times higher than men to have this disease ?

    Dr Terry Wahls has done a lot of research on MS see here http://thelowcarbdiabetic.blogspot.co.uk/2015/08/how-i-went-from-wheelchair-to-walking.html

    but more research is to be welcomed ...

    All the best Jan
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    chris c
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    Re: Vitamin D could repair nerve damage in multiple sclerosis, study suggests

    Post by chris c on Wed Dec 30 2015, 21:23

    Would be interesting if this, as well as the pre-eclampsia in the previous post, both turned out to be increasing since low fat diets were invented (vitamin D is fat soluble)

    I remember someone coming on a newsgroup panicking about the large number of conditions that were caused by vitamin D. The fool had completely misread the research - they were all conditions caused by a LACK of vitamin D!

    I've read that D3 is the correct form, and preferably in gel caps. Cholecalciferol may help explain where it comes from. The vegetable equivalent - D2 - ergocalciferol - needs converting for use by the body, which may not occur. Guess which type the NHS prescribes?

      Current date/time is Tue Sep 26 2017, 15:29