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    Researchers devise new diabetes diagnostic tool

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    yoly
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    Researchers devise new diabetes diagnostic tool

    Post by yoly on Wed Nov 18 2015, 14:04


    Researchers devise new diabetes diagnostic tool

    Researchers at University of Exeter have developed a new test to help diagnose diabetes, which they say will lead to more effective diagnosis and patient care.

    Research published in the journal Diabetes Care, shows how a genetic test can help doctors to differentiate between type 1 and type 2 diabetes in young adults.

    With rising obesity levels it is sometimes difficult for doctors to distinguish between type 1 diabetes, which requires treatment with insulin injections and type 2 diabetes, which can be controlled through diet and weight loss. The Exeter team has devised a genetic risk score which can help identify people between 20 and 40 who will require insulin treatment.

    “This will be an important addition to correctly classifying individuals with diabetes and will improve the number of people who get the right treatment when they are first diagnosed, especially people who sit in the overlap between type 1 and type 2 diagnosis,” said Dr Richard Oram, National Institute for Health Research Clinical Lecturer and specialist in Diabetes and Nephrology at the University of Exeter Medical School.

    “There is often no going back once insulin treatment starts. This may save people with Type 2 diabetes from being treated with insulin unnecessarily, but also stop the rare but serious occurrence of people with Type 1 being initially treated with tablets inappropriately and running of the risk of severe illness.”

    In work supported by NIHR and the Wellcome Trust, the Exeter researchers devised a test which measures 30 genetic variants in DNA and combines all the risks associated with them in a single score, which can then act as a summary of genetic risk for type 1 diabetes. If a person’s score is high they are likely to have type 1 diabetes, if it is low then it will be type 2.

    The researchers believe this will provide important additional information for doctors when making a diagnosis and suggest that the test can be used in addition to an existing commonly used test which measures anti-bodies.

    Dr Oram says it will also benefit patients' understanding and attitude towards their condition. “Having this information about their diabetes and about their genetic risk will make a big difference to the way people feel about their care. If you speak to people with diabetes they often want to know why they have developed the disease and whether some of their risk for the disease is genetic.”

    The Exeter team is now working to develop a test that any clinical laboratory could run cheaply and quickly.

    The University of Exeter is one of the world’s leading centres in genome-wide association studies. This latest development demonstrates how scientific understanding in this area can be translated into improved clinical care.

    Dr Mike Weedon, of the University of Exeter Medical School, said: “We think this is a really good example of taking results from large-scale genetic studies and translating them into clinical practice and improved patient care.”

    The paper, entitled “A Type 1 diabetes genetic risk score can aid discrimination between Type 1 and Type 2 diabetes in young adults”, is published in Diabetes Care on November 17.

    Date: 17 November 2015

    http://www.exeter.ac.uk/news/featurednews/title_481157_en.html
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    Eddie
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    Re: Researchers devise new diabetes diagnostic tool

    Post by Eddie on Wed Nov 18 2015, 15:17

    Great post thanks for the information lets hope it proves useful. Sorry to be the voice of doom but...

    Over seven years ago I asked a diabetes health professional "why don't you do a BG test on every over weight person or on people that have generations of type two diabetes running through their families" she replied "because we could not afford it" I said "what the price of a test strip when patients come in for an appointment unrelated too expensive" her reply "that's not the problem, the problem is we know we would diagnose so many new diabetics the whole system would collapse"

    BTW A test giving years of advanced warning for type two diabetics has been around for a long time, it's called a plasma insulin test. One of the first tests Dr. Bernstein does with new patients. Not done by the NHS too expensive evidently.



    _________________
    Type two diabetic-low carb diet (50 carbs per day) and two 500mg Metformin pills per day. Apart from diagnosis HbA1c almost 12-all HbA1c results none diabetic. For over eight years my diabetes medication has not changed. My weight has remained stable, I have suffered no ill effects from my diet whatsoever. Every blood test has proved, I took the right road to my diabetic salvation. For almost seven years, I have asked medical professionals and naysayers, how do I maintain non diabetic BG levels on two Metformin other than low carb ? The silence has been deafening !
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    chris c
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    Re: Researchers devise new diabetes diagnostic tool

    Post by chris c on Thu Nov 19 2015, 20:53

    Andrew Hattersley at Peninsular Medical School, Exeter, is world class Diabetes genes

    Over time I've met a whole bunch of adult onset Type 1/LADA diabetics who were diagnosed as Type 2 simply because of age of onset. Also not a few MODY and other genetic Type 2s who were misdiagnosed as Type 1 (Halle Berry comes immediately to mind).

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