The Low Carb Diabetic

Promoting a low carb high fat lifestyle for the safe control of diabetes. Eat whole fresh food, more drugs are not the answer.


Welcome to the Low Carb Diabetic forum,have you signed up yet? if not then sign up and join us in the low carb community today!

    Invokana May Increase Bone Fracture Risk: FDA

    Share
    avatar
    graham64
    Member

    Status :
    Online
    Offline

    Male Posts : 3075
    Join date : 2014-08-10
    Location : Lancs

    Invokana May Increase Bone Fracture Risk: FDA

    Post by graham64 on Thu Sep 10 2015, 23:25

    Follows evidence linking the SGLT2 inhibitor to fractures

    The FDA strengthened the warning for type 2 diabetes drug canagliflozin (Invokana, Invokamet) to note that the drugs may increase the risk of bone fracture and decrease bone mineral density.

    In a drug safety communication, posted today, the agency said they have added a new warning and precaution and have revised the adverse reactions section of the drug labels to reflect this fact.

    Last year, a researcher wrote in Lancet Diabetes & Endocrinology that there is a possible relationship between the drug, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, and bone fractures, especially for post-menopausal women. She cited numerous studies showing a possible link as evidence.

    The FDA said that healthcare professionals should consider factors that may contribute to fracture risk before starting their patients on canagliflozin. They also added the following information:


    1. Bone fractures have been seen in patients on canagliflozin
    2. Fractures can occur as early as 12 weeks after starting the drug
    3. In addition to bone fractures, canagliflozin has also been linked to decreases in bone mineral density at the hip and lumbar spine  


    More here:  http://www.medpagetoday.com/Endocrinology/Diabetes/53490?


    _________________
    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over nine years,

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
    avatar
    chris c
    Member

    Status :
    Online
    Offline

    Posts : 3378
    Join date : 2015-07-26

    Re: Invokana May Increase Bone Fracture Risk: FDA

    Post by chris c on Fri Sep 11 2015, 18:20

    So you not only piss away all the excess sugar, you piss your bones down the toilet too. Just great . . .
    avatar
    Eddie
    Member

    Status :
    Online
    Offline

    Male Posts : 3767
    Join date : 2014-08-13
    Age : 67
    Location : London

    Re: Invokana May Increase Bone Fracture Risk: FDA

    Post by Eddie on Sat Sep 12 2015, 08:06

    @chris c wrote:So you not only piss away all the excess sugar, you piss your bones down the toilet too. Just great . . .

    Other than Metformin I have never heard of a type two med that does not carry possible serious side effects. Even big pharma's own literature only confirms a very modest reduction in HbA1c err... maybe. We know a type two going onto insulin can carry a three times greater risk of mortality, dose dependent. Not to mention the huge grief of being insulin dependent, such as driving licence, insurance, hypo's need I go on.

    The question I have asked for a long time, why do a group of type ones at the flog, want to kill off as many type two's as they can. Why do these people constantly meddle in type two discussions. As Indy said at the flog early this morning "I guess I've come in late and have a lot of reading to catch up on, but I'm wondering why this has morphed into a discussion about Type 1 when Kraft's work (his book is called 'Diabetes Epidemic & You') is related to the aetiology of Type 2? Seems to me discussing Type 1 in this context is just muddying the waters?"

    Answers on a post card please.


    _________________
    Type two diabetic-low carb diet (50 carbs per day) and two 500mg Metformin pills per day. Apart from diagnosis HbA1c almost 12-all HbA1c results none diabetic. For over eight years my diabetes medication has not changed. My weight has remained stable, I have suffered no ill effects from my diet whatsoever. Every blood test has proved, I took the right road to my diabetic salvation. For almost seven years, I have asked medical professionals and naysayers, how do I maintain non diabetic BG levels on two Metformin other than low carb ? The silence has been deafening !
    avatar
    chris c
    Member

    Status :
    Online
    Offline

    Posts : 3378
    Join date : 2015-07-26

    Re: Invokana May Increase Bone Fracture Risk: FDA

    Post by chris c on Sat Sep 12 2015, 20:06

    I didn't look much at the Type 1 threads when I posted there but I predict most of the same gang who COULD have helped the Type 1s didn't, am I right?

    Agreed on the metformin which appears to have a whole bunch of benefits and not only for diabetics, and agreed on the potential toxicity of most other Type 2 meds, and the fact they don't have but a fraction of the effect of a decent diet.

    What's the betting that even now the drug companies are about to announce an antidote which stops the bone loss and only costs £99/month?
    avatar
    graham64
    Member

    Status :
    Online
    Offline

    Male Posts : 3075
    Join date : 2014-08-10
    Location : Lancs

    Re: Invokana May Increase Bone Fracture Risk: FDA

    Post by graham64 on Sun Sep 13 2015, 00:18

    @chris c wrote:So you not only piss away all the excess sugar, you piss your bones down the toilet too. Just great . . .

    UTI's, DKA and now bone fractures wonderful  facepalm still the drug must be a far safer option than LC  which due to worries about the long term effects is frowned upon by the powers that be.

    But what do I know apart from I've never had a UTI a DKA nor a bone fracture in over seven years of LC  Rolling Eyes


    _________________
    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over nine years,

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
    avatar
    chris c
    Member

    Status :
    Online
    Offline

    Posts : 3378
    Join date : 2015-07-26

    Re: Invokana May Increase Bone Fracture Risk: FDA

    Post by chris c on Sun Sep 13 2015, 18:02

    Or scurvy, or bad breath, or a lack of energy, or . . . or . . .
    avatar
    Paul1976
    Moderator

    Status :
    Online
    Offline

    Male Posts : 2434
    Join date : 2014-08-12
    Age : 41
    Location : East midlands,UK

    Re: Invokana May Increase Bone Fracture Risk: FDA

    Post by Paul1976 on Sun Sep 13 2015, 18:11

    @chris c wrote:Or scurvy, or bad breath, or a lack of energy, or . . . or . . .

    ...Or...Any weight loss achieved on LCHF is due to the skeleton shrinking due to osteoporosis!! facepalm facepalm wtf

    Damn! I wish I could find the link to where that load of shite was implied-I "Believe" it may have been from a commenter on the 'Carbsane asylum' blog! facepalm
    avatar
    chris c
    Member

    Status :
    Online
    Offline

    Posts : 3378
    Join date : 2015-07-26

    Re: Invokana May Increase Bone Fracture Risk: FDA

    Post by chris c on Sun Sep 13 2015, 18:24

    She should be prosecuted under the Trades Description Act
    avatar
    graham64
    Member

    Status :
    Online
    Offline

    Male Posts : 3075
    Join date : 2014-08-10
    Location : Lancs

    Re: Invokana May Increase Bone Fracture Risk: FDA

    Post by graham64 on Sun Sep 13 2015, 22:14

    @chris c wrote:I didn't look much at the Type 1 threads when I posted there but I predict most of the same gang who COULD have helped the Type 1s didn't, am I right?

    Yep that sums it up,  phoenix was busy sticking her nose in T2 low carb threads whilst virtually ignoring cries for help from newly diagnosed LADA's and other insulin dependents.

    One things for sure she never intervenes in the T1 low carb threads warning of the dire consequences of following LC


    _________________
    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over nine years,

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
    avatar
    chris c
    Member

    Status :
    Online
    Offline

    Posts : 3378
    Join date : 2015-07-26

    Re: Invokana May Increase Bone Fracture Risk: FDA

    Post by chris c on Mon Sep 14 2015, 19:33

    Sid is an obvious buffoon, I've met not a few in other places too. Phoenix is knowledgeable enough to be actively dangerous. Are there any clueful Type 1s left over there? I learned a lot from Fergus and his ilk, especially some clueful pumpers who demonstrated just how much work an unbroken pancreas has to do by emulating it on their pump settings. They would use different basal rates at different times of day, and different carb-insulin ratios, then a load of different profiles for highly active or passive days etc.

    Naturally they all used these settings to trim the effects of a low carb diet, and only turned things up to eat a "normal" meal when it was unavoidable.
    avatar
    Paul1976
    Moderator

    Status :
    Online
    Offline

    Male Posts : 2434
    Join date : 2014-08-12
    Age : 41
    Location : East midlands,UK

    Re: Invokana May Increase Bone Fracture Risk: FDA

    Post by Paul1976 on Mon Sep 14 2015, 19:39

    @chris c wrote:Sid is an obvious buffoon, I've met not a few in other places too. Phoenix is knowledgeable enough to be actively dangerous. Are there any clueful Type 1s left over there? I learned a lot from Fergus and his ilk, especially some clueful pumpers who demonstrated just how much work an unbroken pancreas has to do by emulating it on their pump settings. They would use different basal rates at different times of day, and different carb-insulin ratios, then a load of different profiles for highly active or passive days etc.

    Naturally they all used these settings to trim the effects of a low carb diet, and only turned things up to eat a "normal" meal when it was unavoidable.

    Well,at the very least,thank god it looks like the despotic Jopar appears to have left the world of diabetes fora! Nasty bit of work IMO who just loved to troll every T2 and LCHF thread just for fun! Rolling Eyes
    avatar
    chris c
    Member

    Status :
    Online
    Offline

    Posts : 3378
    Join date : 2015-07-26

    Re: Invokana May Increase Bone Fracture Risk: FDA

    Post by chris c on Mon Sep 14 2015, 19:47

    Obviously not banned, did she just leave or find a different playground?
    avatar
    Paul1976
    Moderator

    Status :
    Online
    Offline

    Male Posts : 2434
    Join date : 2014-08-12
    Age : 41
    Location : East midlands,UK

    Re: Invokana May Increase Bone Fracture Risk: FDA

    Post by Paul1976 on Mon Sep 14 2015, 20:00

    @chris c wrote:Obviously not banned, did she just leave or find a different playground?

    She just 'Appears' to have called it a day,seemed to disappear around the same time as Carbo gave up the ghost with his blog.
    avatar
    chris c
    Member

    Status :
    Online
    Offline

    Posts : 3378
    Join date : 2015-07-26

    Re: Invokana May Increase Bone Fracture Risk: FDA

    Post by chris c on Mon Sep 14 2015, 20:09

    She may be putting the wind up the newbies on the Official DUK Forum, I saw one or two of the other anti-low-carbers over there but can't bear to look nowadays. I do know one or two clueful people who post there and try to help, but among all the "I got my A1c down to 8!" "Hugs!!!" type threads I despaired long ago.
    avatar
    Eddie
    Member

    Status :
    Online
    Offline

    Male Posts : 3767
    Join date : 2014-08-13
    Age : 67
    Location : London

    Re: Invokana May Increase Bone Fracture Risk: FDA

    Post by Eddie on Mon Sep 14 2015, 20:28

    @chris c wrote:Sid is an obvious buffoon, I've met not a few in other places too. Phoenix is knowledgeable enough to be actively dangerous. Are there any clueful Type 1s left over there? I learned a lot from Fergus and his ilk, especially some clueful pumpers who demonstrated just how much work an unbroken pancreas has to do by emulating it on their pump settings. They would use different basal rates at different times of day, and different carb-insulin ratios, then a load of different profiles for highly active or passive days etc.

    Naturally they all used these settings to trim the effects of a low carb diet, and only turned things up to eat a "normal" meal when it was unavoidable.

    "Phoenix is knowledgeable enough to be actively dangerous." No one can argue Phoenix is not a very bright person. The $64,000 question must be, why she has spent the last six years, trying to bring so many low carbers and diabetics down?

    My opinion, she is a psychopathic retard. None stop meddling in type two threads. Forever pushing her high carb low fat agenda. Which she must know, is a one way ticket to Palookaville for us type two's, and most type ones. Maybe she gets some sort of sexual buzz from her work. But the bright see thorough her, and her ilk.



    _________________
    Type two diabetic-low carb diet (50 carbs per day) and two 500mg Metformin pills per day. Apart from diagnosis HbA1c almost 12-all HbA1c results none diabetic. For over eight years my diabetes medication has not changed. My weight has remained stable, I have suffered no ill effects from my diet whatsoever. Every blood test has proved, I took the right road to my diabetic salvation. For almost seven years, I have asked medical professionals and naysayers, how do I maintain non diabetic BG levels on two Metformin other than low carb ? The silence has been deafening !
    avatar
    graham64
    Member

    Status :
    Online
    Offline

    Male Posts : 3075
    Join date : 2014-08-10
    Location : Lancs

    Re: Invokana May Increase Bone Fracture Risk: FDA

    Post by graham64 on Mon Sep 14 2015, 21:37

    @Paul1976 wrote:
    @chris c wrote:Sid is an obvious buffoon, I've met not a few in other places too. Phoenix is knowledgeable enough to be actively dangerous. Are there any clueful Type 1s left over there? I learned a lot from Fergus and his ilk, especially some clueful pumpers who demonstrated just how much work an unbroken pancreas has to do by emulating it on their pump settings. They would use different basal rates at different times of day, and different carb-insulin ratios, then a load of different profiles for highly active or passive days etc.

    Naturally they all used these settings to trim the effects of a low carb diet, and only turned things up to eat a "normal" meal when it was unavoidable.

    Well,at the very least,thank god it looks like the despotic Jopar appears to have left the world of diabetes fora! Nasty bit of work IMO who just loved to troll every T2 and LCHF thread just for fun!  Rolling Eyes

    Complete fruit cake Jopar Rolling Eyes I used to fall about laughing at some of the stuff she posted, a classic was were she claimed Bernstein had impinged her human rights affraid I had visions of the good doctor sending his heavies round to her place to ensure she complied with his dietary advice  Laughing


    _________________
    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over nine years,

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes
    avatar
    chris c
    Member

    Status :
    Online
    Offline

    Posts : 3378
    Join date : 2015-07-26

    Re: Invokana May Increase Bone Fracture Risk: FDA

    Post by chris c on Tue Sep 15 2015, 17:37

    I knew another clueless Type 1 on a pump elsewhere who called him Bernsquack. Needless to say she was obese and failed to understand why . . .

    Sponsored content

    Re: Invokana May Increase Bone Fracture Risk: FDA

    Post by Sponsored content


      Current date/time is Thu Nov 23 2017, 18:22