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    Victoza has failed T1 trials.


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    Victoza has failed T1 trials.

    Post by Eddie on Wed Sep 09 2015, 15:10

    "Novo Nordisk’s diabetes drug Victoza has failed a trial that assessed its suitability to be added to insulin therapy. The drug, which is a brand name for liraglutide, made episodes of low blood sugar significantly worse. The study showed that adding Victoza to insulin therapy did aid blood glucose control better than a placebo, but the risk of hypoglycemia immediately after treatment was too great. Liraglutide is currently only used to treat type 2 diabetes. Novo Nordisk was hoping that, following successful trials, its use could be expanded to cover type 1 diabetes treatment, too. The trial involved around 1,400 patients, all of whom were treated with insulin. On top of the insulin, each patient was given either one of three doses of liraglutide – 0.6mg, 1.2mg, or 1.8mg – or a placebo. The higher two doses of liraglutide were more effective than placebo when it came to reducing HbA1c levels. They also aided weight loss. The 0.6mg dose performed even worse than the placebo. However, the risk of hypoglycemia associated with liraglutide treatment was considered too great. "Based on a risk/benefit assessment of the overall dataset from the two ADJUNCT trials, Novo Nordisk does currently not intend to submit an application to expand the label of Victoza for use in type 1 diabetes," said the company in a statement."

    Nicked from the flog.

    No surprise that went down like a rubber beak on a woodpecker, it's a pretty useless drug for type two diabetics, Google side effects and pending Court Cases in the US. I liked the "The 0.6mg dose performed even worse than the placebo" often the case with type two meds and "risk of hypoglycemia associated with liraglutide treatment was considered too great" so, best given a wide berth I reckon.

    How many times do we see big pharma trying to wring some extra mileage out of their drugs? or a minute alteration and going for new patent application, they never give up. Obviously type one's need insulin, some other type's of diabetics need insulin, but almost all type two meds are useless, expensive and dangerous. Last time Graham checked there were over 200 type two diabetes drugs in the pipe line, Oh how big pharma must hate low carbers eh. If all diabetics went low carb at least a few of the big pharma companies would go down the tubes, my heart bleeds for the poor blighter's. mrgreen

    Type two diabetic-low carb diet (50 carbs per day) and two 500mg Metformin pills per day. Apart from diagnosis HbA1c almost 12-all HbA1c results none diabetic. For over eight years my diabetes medication has not changed. My weight has remained stable, I have suffered no ill effects from my diet whatsoever. Every blood test has proved, I took the right road to my diabetic salvation. For almost seven years, I have asked medical professionals and naysayers, how do I maintain non diabetic BG levels on two Metformin other than low carb ? The silence has been deafening !

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